DLBS3233 increases glucose uptake by mediating upregulation of PPARγ and PPARδ expression

Nailufar, Florensia; Tandrasasmita, Olivia Mayasari; Tjandrawinata, Raymond R.

doi:10.1016/j.bionut.2010.12.002

Cited by 10 publications

(20 citation statements)

References 24 publications

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“…Our study showed that augmentation of insulin sensitivity by DLBS3233, through its insulin-sensitizing properties, 20 , 21 was finally compensated by a significant reduction – which can also be translated as normalization – of the first- and second-phase insulin levels as shown in DLBS3233-treated group after 8 and 12 weeks. This result indicates an insulin-sparing effect of the treatment.…”

Section: Discussionsupporting

confidence: 49%

“…In vitro studies with 3T3-Swiss-Albino preadipocyte cells showed that stimulation of insulin-signaling transduction by DLBS3233 occurred through the promotion of tyrosine phosphorylation of the insulin-receptor-substrate and upregulation of the expression of phosphatidylinositol-3-kinase, PPAR-γ, PPAR-δ, and glucose transporter-4 at the mRNA level. 20 , 21 Activation of PPAR-γ and PPAR-δ by DLBS3233 leads to a series of beneficial metabolic effects on glucose and lipids, suggesting that the product possesses the potential capacity to decrease the incidence of insulin resistance-associated diseases.…”

Section: Discussionmentioning

confidence: 99%

“…DLBS3233, a novel bioactive fraction derived from the plants Cinnamomum burmanii and Lagerstroemia speciosa , has previously been studied for its insulin-sensitizing activity. 20 , 21 C . burmanii was obtained from Kerinci, Jambi, Indonesia, and L .…”

Section: Introductionmentioning

confidence: 99%

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Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa

Manaf

Tjandrawinata²,

Malinda

2016

DDDT

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BackgroundThe aim of this paper is to evaluate the efficacy and safety of DLBS3233, a novel bioactive fraction derived from Cinnamomum burmanii and Lagerstroemia speciosa, in improving insulin resistance and preserving β-cell performance in patients with impaired glucose tolerance (IGT).Patients and methodsEighty adult subjects with IGT, defined as 2-hour postprandial glucose level of 140–199 mg/dL, were enrolled in this two-arm, 12-week, double-blind, randomized, placebo-controlled preliminary study. Eligible subjects were randomly allocated to receive either DLBS3233 at a dose of 50–100 mg daily or placebo for 12 weeks. The study mainly assessed the improvement of homeostatic model-assessed insulin resistance (HOMA-IR), the 15-minute and 2-hour plasma insulin levels, and the oral disposition index.ResultsAfter 12 weeks, DLBS3233 improved insulin resistance better than placebo as reflected by a reduced HOMA-IR (−27.04%±29.41% vs −4.90%±41.27%, P=0.013). The improvement of the first- and second-phase insulin secretion was consistently greater in DLBS3233 group than placebo group (−144.78±194.06 vs −71.21±157.19, P=0.022, and −455.03±487.56 vs −269.49±467.77, P=0.033, respectively). Further, DLBS3233 also significantly better improved oral disposition index than placebo. No serious hypoglycemia, edema, or cardiovascular-related adverse events were found in either groups.ConclusionThis study has shown that DLBS3233 at the dose of 50–100 mg once daily was well tolerated, and promisingly efficacious in improving insulin sensitivity as well as preserving β-cell performance in subjects with IGT.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa

Manaf

Tjandrawinata²,

Malinda

2016

DDDT

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“…[8][9][10][11] Natural-based remedies have also been recently recommended to substitute the uses of fluoride and other chemical compounds addressed for oral health. Exhibiting good antimicrobial activity, Nigella sativa L. seed, known as black cumin, has been widely used as food preservatives.…”

Section: Ijpsr (2017) Volume 8 Issue 7 (Research Article)mentioning

confidence: 99%

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2017

IJPSR

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Our previous study highlighted the antimicrobial activity evaluation of Nigella sativa seed oil extract that was obtained from supercritical fluid extraction using carbon dioxide (SCFE-CO 2 ) on Gram positive pathogenic bacteria. The aim of this study was to formulate oil-in-water (o/w) emulsion of previous N. sativa seed oil extract and to investigate its antimicrobial activity against Streptococcus mutans and Streptococcus sanguis as the most common causative bacteria of dental caries. Oil-in-water emulsion containing 10% N. sativa seed oil extract (DLBS1355) exhibited good inhibition activity on both S. mutans and S. sanguis. Time-kill assay and biofilm inhibition assay were conducted using emulsion with 0.5% N. sativa seed oil extract content. The results showed bactericidal and biofilm inhibition activities on both tested bacteria. Antimicrobial activity of the emulsion was found higher on S. sanguis than S. mutans. Results of the present study showed that emulsification process did not significantly affect the antimicrobial activity of N. sativa seed oil extract and the formulated N. sativa oil-in-water emulsion could further be used as an antimicrobial agent against dental cariogenic bacteria.

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“…16 The combination of Lagerstroemia speciosa and C. burmannii has been shown to increase glucose uptake in vitro and in vivo. 6,17 DLBS2411, a standardized extract containing C. burmannii, was previously reported to have an effect on hydrogen/potassium adenosine triphosphate (H + /K + -ATPase) activity and to downregulate the expression of the gene encoding the enzyme. DLBS2411 was also reported to possess antioxidant activity and to show gastroprotective properties on acetic acid-induced gastric ulcer.…”

Section: Introductionmentioning

confidence: 99%

<p>Gastroprotective Effect of DLBS2411 Bioactive Fraction from <em>Cinnamomum burmannii</em> Against Ethanol-Induced Gastric Damage in Rats</p>

Tjandrawinata¹,

Nailufar²

2020

JEP

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Background: The study was carried out to evaluate the anti-ulcerative and gastroprotective effect of DLBS2411, a bioactive fraction from Cinnamomum burmannii (Nees & T. Nees) Blume, in Wistar rats (Rattus norvegicus). Methods: The rats were divided into five treatment groups, which were the Normal control group, Negative control group (ethanol-induced) and two treatment groups: DLBS2411 at the doses of 25 mg/kg body weight (BW) and 50 mg/kg BW, and the Positive control group treated with sucralfate at the dose of 100 mg/kg BW. Gastroprotective effect was measured by the ulcerative lesion index, ulcer surface area, percentage of lesion area, and cure ratio. Hematological and histopathological analyses were also conducted to gain additional data regarding the gastroprotective effect of DLBS2411 in the rats' stomachs. Results: DLBS2411 was found to contain not less than 15% of total phenolic compounds. Treatment with DLBS2411 at doses of 25 mg/kg BW and 50 mg/kg BW significantly reduced the percentage of ulcer area in rats. The percentage of ulcer area for the Negative control group and both doses in the DLBS2411 treatment group reached 22.64±6.82%, 6.75 ±4.41%, and 6.18±4.63%, respectively. Ulcer surface area in the treatment groups and Positive control group also decreased. Histopathological data showed that gastric epithelial cells in the Negative control group were more severely ulcerated than in the treatment group of DLBS2411 and the Positive control group. Conclusion: This study showed that DLBS2411 at the dose of 50 mg/kg BW was more effective in protecting the stomach lining than DLBS2411 at the dose of 25 mg/kg BW, as measured by percentage of ulceration inhibition and the ulcerative lesion index.

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DLBS3233 increases glucose uptake by mediating upregulation of PPARγ and PPARδ expression

Cited by 10 publications

References 24 publications

Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa

Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa

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<p>Gastroprotective Effect of DLBS2411 Bioactive Fraction from <em>Cinnamomum burmannii</em> Against Ethanol-Induced Gastric Damage in Rats</p>

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