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Delcò, Fabiola; El–Serag, Hashem B.; Sonnenberg, Amnon

doi:10.1023/a:1026660614372

Cited by 39 publications

(4 citation statements)

References 41 publications

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“…The prevalence of CeD (1:100) multiply exceeds that of IBD (CD 0,1–16:10 4 , UC 0,5–25:10 4 ) in general population [ 8 ]. Previous studies showed, that the prevalence of IBD is 5–10 times higher in CeD compared with that of the general population [ 9 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

et al. 2015

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BackgroundCeliac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period.MethodsTo diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient.ResultsIn our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22–67), 6/8 Crohn’s disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn’s disease patients are B1, 2/6 Crohn’s disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients.ConclusionsWithin our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population.

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Section: Discussionmentioning

confidence: 99%

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

et al. 2015

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“…Some authors consider CD[ 25 ] or UC[ 26 ] patients at high risk of presenting CeD[ 27 - 32 ] and others don’t[ 26 , 32 , 33 ]. However, none determine the frequency of HLA-CeD in their patients, although Leeds points out that HLA-CeD could be less frequent in IBD patients than in the general population[ 33 ].…”

Section: Discussionmentioning

confidence: 99%

HLA-DQ: Celiac diseasevsinflammatory bowel disease

Bosca-Watts

Mínguez

Planelles³

et al. 2018

WJG

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AIMTo determine the genetic predisposition to celiac disease (CeD) in inflammatory bowel disease (IBD) patients by quantifying the frequency of CeD-related human leucocyte antigen (HLA) (HLA-CeD: HLA-DQ2 and -DQ8) in IBD patients globally, by type of IBD and gender, and by calculating the protective/risk contribution of these haplotypes in the development of the IBD disease.METHODSWe conducted a prospective study with IBD patients from our Unit. Clinical information was gathered and blood was tested for HLA-CeD. The control group was made up of unrelated Valencian organ donors.RESULTS1034 subjects were analyzed: 457 IBD [207 ulcerative coliti (UC) and 250 Crohn’s disease (CD)] patients and 577 healthy controls. 39% of the controls and 34% of the patients had HLA-CeD (P = 0.0852). HLA-DQ2 was less frequent in UC patients (P = 0.0287), and HLA-DQ8 in CD (P = 0.0217). In women with UC, the frequency of DQ2.5cis (DQB1*02:01-DQA1*05:01) was reduced ≥ 50% [P = 0.0344; preventive fraction (PF) = 13%]. PFs (7%-14%) were obtained with all HLA-CeD haplotypes. HLA DQB1*02:02-DQA1*02:01 (HLA-DQ2.2) was more frequent in CD patients with respect to controls (P = 0.001) and UC patients (etiological fraction = 15%).CONCLUSIONHLA-CeD is not more frequent in IBD patients, with an even lower frequency of HLA-DQ2 and -DQ8 in UC and CD respectively. HLA-DQ2.5 confers protection from the development of UC, especially in women, and HLA-DQ8 does so for the appearance of CD. HLA-DQ2.2 is present in 34% of the CD patients and may constitute a genetic risk factor for CD development.

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“…As a matter of fact, malnutrition has been ascribed as a cause of chronic pancreatitis in nonalcoholic young patients in underdeveloped countries [42, 43, 44]; this possible etiology has not yet been identified in Mexico [45]. Accordingly, several authors have proposed protein-calorie malnutrition as a mechanism of temporary abnormal pancreatic function in patients with intestinal diseases such as CS [1, 4, 5, 46]. …”

Section: Discussionmentioning

confidence: 99%

Exocrine Pancreatic Insufficiency in Tropical Sprue

Morales¹,

Galván²,

Mery³

et al. 2001

Digestion

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Background: Pancreatic insufficiency may appear secondary to several intestinal disorders. It may contribute to malabsorption in tropical sprue (TS). Methods: The exocrine pancreatic function was evaluated with the indirect pancreolauryl test (PT) in 56 patients with TS. The PT results were analyzed and correlated with serum albumin levels, degree of intestinal atrophy, and steatorrhea. Results: Abnormally low values were found in 36 (64.2%) cases. A significant relationship was not observed between PT and hypoalbuminemia. Patients with more severe damage by intestinal biopsy tended to have lower PT values. No relationship was found between pancreatic insufficiency and steatorrhea (expressed as g/24 h), but patients with pancreatic insufficiency had increased stool fat concentrations (expressed as percentage of wet stool weight). All patients responded favorably to treatment with folic acid and tetracycline. Fifteen patients with abnormal initial PT values underwent a repeat PT after a 6-week therapy; all of them showed normalization of PT values. Conclusions: The abnormal exocrine pancreatic function found with an indirect test in patients with TS is probably secondary to a low pancreatic hormonal stimulation due to intestinal damage, as occurs in celiac sprue. These abnormalities are reversible after specific treatment for TS.

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Cited by 39 publications

References 41 publications

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

HLA-DQ: Celiac diseasevsinflammatory bowel disease

Exocrine Pancreatic Insufficiency in Tropical Sprue

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