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Albrecht, Clemens; Weiss, Elisabeth; Schulz‐Schaeffer, Walter; Albrecht, Tanja; Fauser, Susanne; Wickboldt, J.; Hess, Clemens F.

doi:10.1023/a:1022118317876

Cited by 56 publications

(18 citation statements)

References 25 publications

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“…By now, 106 cases[1–57–912–141617192325–32363841–5052–5456–6266–6870717377–79818486–9092939597–113115116] of primary intraspinal EES/pPNET (extradural/intradural extramedullary lesions) and 29 cases[31118202228353740515255697172808283859194114] of primary intramedullary PNET (CNS-PNET) have been reported in the literature [Tables 1 and 2]. In some studies, neither intra- nor extramedullary location of the tumor was mentioned, so they were not included in any of the groups in our review (i.e.…”

Section: Results Of the Meta-analysismentioning

confidence: 99%

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Saeedinia¹,

Nouri²,

Alimohammadi³

et al. 2012

Surg Neurol Int

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Background:Primary spinal primitive neuroectodermal tumors (PNET) and/or spinal extraskeletal Ewing's sarcoma family tumors (ESET) are rare lesions appearing in the spinal extradural space. One hundred forty-one primary spinal PNETs, including 29 intramedullary lesions, have been reported in the literature. Encountering a case of primary epidural EES/peripheral PNET (pPNET) in sacral level, which is the fifth one occurring at this level in the literature, we have tried to conduct a meta-analysis of the reported cases.Case Description:A 44-year-old lady with epidural EES/pPNET is reported here. She was once operated for L5/S1 herniated disc, which did not ameliorate her symptoms. The clinical, imaging, surgical, and histopathologic characteristics of our case are presented and wide search of the literature is also done. All the reports were level 3 or less evidences and most of the series had missing parts. 106 cases of primary intraspinal (extradural/extramedullary-intradural) EES/pPNET and 29 cases of primary intramedullary PNET (CNS-PNET) have been reported in the literature. The most common clinical presentation in both entities was muscle weakness proportionate to the tumor location. Distant metastasis occurred in 38 of 99 (38%) cases of primary intraspinal EES/pPNET, while the rate of metastasis was 48% in patients with PNETs occurring in the intramedullary region (P > 0.05). One-year survival rate of the patients who underwent chemo-radiation after total or subtotal resection was better than those who did not receive chemotherapy or radiotherapy, or did not have total or subtotal resection. However, this difference was not repeated in 2-year survival rate in any of the tumor groups.Conclusion:It seems that total or subtotal removal of the tumor and adjuvant chemo- and radiation therapy can improve the outcome in these patients.

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Section: Results Of the Meta-analysismentioning

confidence: 99%

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Saeedinia¹,

Nouri²,

Alimohammadi³

et al. 2012

Surg Neurol Int

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“…However, even though theoretically an intramedullary PNET should be central in origin, several cases of primary intramedullary pPNET have been confirmed [Table 1]. [2627] Our case represents the 25 th case of primary intramedullary PNET reported in the literature and the 5 th case of confirmed intramedullary peripheral PNET.…”

Section: Discussionmentioning

confidence: 80%

“…The demographics of these cases resonate with a recent review that reiterated that the majority of intraspinal pPNET occurs in young adult males. [21016] However, as Table 2 illustrates, pPNET was only present in half of the cases of intramedullary PNET in which a distinction between pPNET and cPNET could be made.…”

Section: Discussionmentioning

confidence: 99%

Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature

Mulholland¹,

Barkhoudarian²,

Cornford³

et al. 2011

Surg Neurol Int

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Background:The occurrence of primitive neuroectodermal tumors (PNET) in patients with neurofibromatosis type 1 (NF1) has only been reported in two other cases in English-Language literature. Owing to the rarity of intraspinal PNET and the extremely high gene mutation variability in NF1, there is currently no conclusive evidence to suggest that PNET is associated with NF1. Here, we report a case of intradural PNET in a patient with NF1.Case Description:A 27-year-old male underwent a C1-C3 laminectomy for resection of an intramedullary mass. Histopathology and immunohistopathology analysis was performed. Microscopic examination and immunohistochemical staining indicated the mass was a primitive neuroectodermal tumor. Within 1 month after tumor resection, the patient developed leptomeningeal carcinomatosis. The patient was not a candidate for radiation therapy but underwent palliative systemic chemotherapy. He subsequently developed neutropenia and died 3 months after tumor resection.Conclusion:To our knowledge, this is the first reported intraspinal PNET associated with NF1. Genetic analysis of CNS PNETs suggests a possible correlation, but larger case series are needed to support this theory.

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“…Therefore, primary intraspinal PNETs are extremely rare, and to our knowledge, only 38 cases have been reported in the literature so far (table 1) [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26]. The age of the disease manifestation, including our case, ranged from 0 to 69 years, with an average age of 25.1 years.…”

Section: Discussionmentioning

confidence: 99%

Primary Primitive Neuroectodermal Tumor of the Conus Medullaris in an Elderly Patient: A Case Report and Review of the Literature

Shimosawa¹,

Matsumoto²,

Yabe³

et al. 2011

Case Rep Oncol

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Primary spinal primitive neuroectodermal tumors (PNETs) are very rare conditions. Most of these tumors occur in children and young adults. A 63-year-old man with a primary spinal PNET in the conus medullaris from the L1 to L2 level is presented in this report. The optimal treatment of primary spinal PNETs is yet unknown. Surgical resection, radiation therapy, and chemotherapy have been advocated for the treatment of spinal PNET based on PNETs at other sites. However, the outcome is very poor. There are a few reports of cases with long-term survival and no recurrence. In these patients, en bloc resections were performed.

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Cited by 56 publications

References 25 publications

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature

Primary Primitive Neuroectodermal Tumor of the Conus Medullaris in an Elderly Patient: A Case Report and Review of the Literature

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