dl-Aspartic acid administration improves semen quality in rabbit bucks

Macchia, G.; Topo, Enza; Mangano, Nunzio Guido; D’Aniello, Enrico; Boni, Raffaele

doi:10.1016/j.anireprosci.2009.07.009

Cited by 29 publications

(33 citation statements)

References 36 publications

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“…Moreover, aspartic acid supplement can improve semen quality and modulate steroidogenesis [25,26], indicative of its essential role in male reproduction. We found that aspartic acid was markedly elevated in pregnant PCOS patients, and our data suggest it as a beneficial metabolite for pregnancy outcome in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome

Zhang

Zhao

et al. 2014

BMC Pregnancy Childbirth

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BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder frequently accompanied by obesity and by insulin resistance, and patients with this syndrome suffer from infertility and poor pregnancy outcome. Disturbances in plasma amino acid (AA) metabolism have been implicated in women with PCOS. However, direct evidence on follicular AA metabolic profiles in PCOS patients and their relationship with pregnancy outcome is sparse.MethodsWe conducted a prospective study in 63 PCOS patients and 48 controls in the Division of Reproductive Center, Peking University Third Hospital. Follicular AA levels were measured by the liquid chromatography-tandem mass spectrometric method, and the results were analyzed based on different grouping criteria.ResultsThe levels of aromatic amino acid (AAA) increased in PCOS patients independent of obesity (P < 0.05), whereas the levels of branched-chain amino acid (BCAA), glutamic acid, phenylalanine, alanine, and arginine increased with body mass index irrespective of the PCOS status (all P < 0.05). In addition, compared with non insulin resistant-PCOS patients and controls, insulin resistant-PCOS group had higher levels of leucine, valine and glutamic acid (all P < 0.05). In PCOS group, aspartic acid and serine levels were elevated in pregnant patients compared with the non-pregnant subjects (both P < 0.05). Moreover, the levels of BCAA and valine were higher in the non-pregnant group than in the pregnant group (both P < 0.05). The pregnancy rate (45.00%) of subjects with elevated BCAA level was significantly lower than that (66.67%) in control subjects (P = 0.036) at a BCAA cutoff value of 239.10 μM, while the abortion rate was much higher (33.33% versus 2.78%, P = 0.004).ConclusionsBoth PCOS and obesity were accompanied by follicular AA metabolic disturbances, with obesity exerting a more pronounced effect on AA metabolic profiles. The disruptions in specific AAs in the follicular fluid might account for the inferior pregnancy outcome in obese patients and increased risk of abortion in PCOS patients.

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Section: Discussionmentioning

confidence: 99%

Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome

Zhang

Zhao

et al. 2014

BMC Pregnancy Childbirth

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“…The concentration of D-Asp in seminal plasma and in spermatozoa was significantly reduced in oligoasthenoteratospermic men [26]. Moreover, DL-Aspartic acid administration has been reported to improve semen quality in rabbits [37]. …”

Section: Discussionmentioning

confidence: 99%

Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation

Talevi

Barbato

Fiorentino

et al. 2013

Reprod Biol Endocrinol

121

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BackgroundSpermatozoa are extremely vulnerable to oxidative stress caused by the unbalance between concentrations of reactive oxygen species and antioxidant scavenging systems present inside the male reproductive tract. In spite of a large number of clinical studies that claimed the beneficial effects of antioxidant oral administration on sperm physiology and fertility, only a few studies were addressed to evaluate their effects on spermatozoa in vitro. Main aims of the present study were to assess the influence of zinc, D-aspartate and coenzyme Q10, included in the dietary supplement Genadis (Merck Serono), on human sperm motility, DNA fragmentation and lipid peroxidation.MethodsSemen samples, obtained from forty-four patients (23–30 years of age) were enrolled in this study, twenty-four were normospermic and twenty patients were oligospermic. Semen samples were analysed for sperm progressive motility and kinetics through computer assisted analysis, DNA fragmentation and lipid peroxidation.ResultsMain results showed that in both normo and oligospermic samples, total and progressive sperm motility is maintained by in vitro treatment with zinc, D-aspartate and coenzyme Q10, whereas a significant decrease of these parameters occurs in parallel samples incubated in medium alone. Zinc, D-aspartate and coenzyme Q10 also prevented the decrease of sperm kinetics but such an effect was highly significant only in oligospermic samples. Moreover, they also protected spermatozoa by the increase of DNA fragmentation and lipid peroxidation.ConclusionsZinc, D-aspartate and coenzyme Q10 exert a direct protective effect on human spermatozoa preventing the decrease of motility and the increase of DNA fragmentation and lipid peroxidation during in vitro culture.

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“…Interestingly, the amount of d-Asp in human seminal plasma and spermatozoa is significantly reduced in oligoasthenoteratospermic and/or azoospermic donors compared with normospermic donors ( Table 2) [150]. On the other hand, it has been reported that the ingestion of d,l-Asp by rabbit bucks significantly increases the d-Asp content in seminal plasma, whereas the l-Asp content in seminal plasma remains almost unchanged [152]. Administration of d,l-Asp also results in a significant increase in several kinetic parameters of motile spermatozoa that are indicative of sperm quality.…”

Section: Role Of D-asp In Diseasementioning

confidence: 91%

d-Aspartate—An important bioactive substance in mammals: A review from an analytical and biological point of view

Katane

Homma

2011

Journal of Chromatography B

113

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dl-Aspartic acid administration improves semen quality in rabbit bucks

Cited by 29 publications

References 36 publications

Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome

Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome

Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation

d-Aspartate—An important bioactive substance in mammals: A review from an analytical and biological point of view

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