dl -3- n -butylphthalide promotes neuroplasticity and motor recovery in stroke rats

Dl-NBP (Dl-3-N-Butylphthalide) Treatment Promotes Neurological Functional Recovery Accompanied by the Upregulation of White Matter Integrity and HIF-1α/VEGF/Notch/Dll4 Expression

“…Previous study showed that NBP improved rats' functional recovery following spinal cord injury (He et al, 2017), induced neuro-protection, regenerative repair, and functional recovery after traumatic brain injury in mice (Zhao et al, 2017). It also improved chronic cerebral ischemia-induced cognitive deficits in rats and enhanced functional recovery in the endothelin-1-induced focal permanent stroke model (Sun et al, 2017b). Our results showed that dl-NBP improved neurological functional recovery after focal transient ischemic stroke.…”

“…The racemic dl-3-n-butylphthalide (dl-NBP) was chemically synthesized, and it resolved this problem. Although dl-NBP, which was approved by the FDA of China for the treatment of acute ischemic stroke in 2002 , has been shown to promote neuroplasticity, motor recovery in stroke rats (Sun et al, 2017b), and enhance the remyelination process and white matter integrity using an endothelin-1 focal permanent cerebral ischemia model that could mimic those patients who have no opportunity to receive either tPA thrombolysis or endovascular therapy, it is not clear whether dl-NBP could promote functional recovery in a focal transient cerebral ischemia model that could mimic those patients who have opportunity to receive either tPA thrombolysis or endovascular therapy. Using a focal transient mice MCAO model, we collected several important findings: 1) dl-NBP treatment promoted functional recovery assessed by neurological scores and adhesive remove test; 2) dl-NBP treatment promoted white matter integrity; 3) dl-NBP treatment increased the number of microvessels and upregulated the expression of the tight junction protein occluding; and 4) dl-NBP treatment upregulated the expression of HIF-1a-VEGF and Notch-Dll4.…”

“…Dl-NBP has been shown to promote neurological functional recovery in stroke rats in an endothelin-1-induced focal permanent ischemic stroke model (Sun et al, 2017b). Here, we examined the effect of dl-NBP on neurological functional recovery in a focal transient ischemic stroke model.…”

“…Although l-NBP has been shown to promote functional recovery by promoting neurogenesis and neuroplasticity after transient focal cerebral ischemic stroke in rats (Yang et al, 2015), there are only limited resources from plant extracts, and it is dl-NBP, not l-NBP, that is currently used in clinic in China. Using an endothelin-1-induced focal permanent stroke model that could mimic those patients who have no opportunity to receive either tPA thrombolysis or endovascular therapy; Sun et al, showed that dl-NBP promoted neuroplasticity and motor recovery of rats (Sun et al, 2017b). However, it is not clear whether dl-NBP could promote functional recovery in a transient focal ischemic stroke model that could mimic those patients who have the opportunity to receive either tPA thrombolysis or endovascular therapy.…”

Dl‐3n‐butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis

“…32 Our previous study showed that basic fibroblast growth factor (bFGF) inhibits BBB disorders through PI3K-Akt-Rac1 signalling and thus improves functional recovery after TBI. 34 There are study showing that Dl-NBP treatment attenuates BBB disruption, reduces EB dye extravasation and decreases the need for immunoglobulin treatment in cerebral ischaemia-reperfusion injury. 34 There are study showing that Dl-NBP treatment attenuates BBB disruption, reduces EB dye extravasation and decreases the need for immunoglobulin treatment in cerebral ischaemia-reperfusion injury.…”