Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway

Gao, Yaran; Hu, Ming; Niu, Xiaoli; Li, Meixi; Xu, Lili; Xiao, Yining; Zhang, Jiawei; Wang, Hebo; Li, Litao; Chu, Bao; Lv, Peiyuan

doi:10.1155/2022/8652741

Cited by 25 publications

(14 citation statements)

References 39 publications

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“…Numerous studies have shown that nerve inflammation mediated by TLR4 activation plays a key role in stroke, AD, and other neurological diseases at the onset of systemic disease. Due to the complex mechanism involved in the pathogenesis, the treatment is controversial, leading to different roles in the study of the neurological inflammatory disease (12)(13)(14). Therefore, we established a VD rat model through 4 vessel occlusion (4-VO) operation.…”

Section: Original Articlementioning

confidence: 99%

Acupoint catgut embedding improves learning and memory impairment in vascular dementia rats

Zhu¹,

Li²,

Wei³

et al. 2023

Ann Transl Med

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Background Vascular dementia (VD) is a disease that affects brain function through cerebrovascular disease. Due to its complex pathogenesis, there is no effective drug treatment for VD. The present study aimed to evaluate the role of acupoint catgut embedding in the treatment of rats with VD and its possible molecular mechanism. Methods A modified 4 vessel occlusion (4-VO) method was used to establish a VD model rat, and spatial learning and memory ability was assessed using the Morris water maze (MWM) test. The protein expression levels were detected by Western blot. Hematoxylin and eosin (HE) staining was used for histological analysis and enzyme-linked immunosorbent assay (ELISA) was applied for analysis of serum inflammatory factors. Results We successfully constructed VD model rats with spatial learning and memory impairment, hippocampus injury, and high inflammatory response. Treatment of VD rats with acupoint catgut embedding significantly reduced escape latency and increased the time in the target quadrant and platform crossing times. VD-mediated hippocampal tissue damage and inflammatory reaction [down-regulating interleukin-1β (IL-1β), interleukin-6 (IL-6)] were significantly alleviated by acupoint catgut embedding treatment. In addition, further mechanism exploration found that acupoint catgut embedding treatment could improve the activity of the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-κB (NF-κB) signaling pathway. In summary, acupoint catgut embedding treatment improved spatial learning and memory loss, alleviated pathological damage of the hippocampus, and inhibited inflammation response in VD rats, which was probably related to the inhibition of the TLR4/MyD88/NF-κB signaling pathway. Conclusions Acupoint catgut embedding may warrant further study as an adjuvant therapy for the treatment of VD.

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Section: Original Articlementioning

confidence: 99%

Acupoint catgut embedding improves learning and memory impairment in vascular dementia rats

Zhu¹,

Li²,

Wei³

et al. 2023

Ann Transl Med

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“…Another study showed that the protective effect of Dl-3-n-butylphthalide (NBP) on neuroinflammation in mice with CIRI was related to Nrf2. Nrf2 regulates the TLR4/MyD88/NF-κB pathway to participate in this neuroprotective effect [ 140 ].…”

Section: Activation Of Nrf2 Signaling Pathway In Cerebral Ischemic St...mentioning

confidence: 99%

“…The regulation of NF-κB activity by Nrf2 is manifested in inhibiting inflammatory responses. Studies have shown that Nrf2 can regulate the TLR4/MyD88/NF-κB pathway in CIRI models and play a neuroprotective role [ 140 ]. Another target gene of Nrf2, p62, can regulate antioxidant and inflammatory activities.…”

Section: The Role and Mechanism Of Nrf2 In Cerebral Ischemic Strokementioning

confidence: 99%

Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

et al. 2022

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Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there are limited effective clinical treatments for cerebral ischemic stroke, and the recovery of cerebral blood circulation will lead to cerebral ischemia-reperfusion injury (CIRI). Cerebral ischemic stroke involves many pathological processes such as oxidative stress, inflammation, and mitochondrial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2), as one of the most critical antioxidant transcription factors in cells, can coordinate various cytoprotective factors to inhibit oxidative stress. Targeting Nrf2 is considered as a potential strategy to prevent and treat cerebral ischemia injury. During cerebral ischemia, Nrf2 participates in signaling pathways such as Keap1, PI3K/AKT, MAPK, NF-κB, and HO-1, and then alleviates cerebral ischemia injury or CIRI by inhibiting oxidative stress, anti-inflammation, maintaining mitochondrial homeostasis, protecting the blood–brain barrier, and inhibiting ferroptosis. In this review, we have discussed the structure of Nrf2, the mechanisms of Nrf2 in cerebral ischemic stroke, the related research on the treatment of cerebral ischemia through the Nrf2 signaling pathway in recent years, and expounded the important role and future potential of the Nrf2 pathway in cerebral ischemic stroke.

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“…* sı Supporting Information ABSTRACT: Five new xenicane diterpenes, including three rare nitrogen-containing derivatives, dictyolactams A (1) and B (2) and 9-demethoxy-9-ethoxyjoalin (3), a rare diterpene with a cyclobutanone moiety, named 4-hydroxyisoacetylcoriacenone (4), and 19-O-acetyldictyodiol (5), were isolated from an East China Sea collection of the brown alga Dictyota coriacea, along with 15 known analogues (6−20). The structures of the new diterpenes were elucidated by spectroscopic analyses and theoretical ECD calculations.…”

mentioning

confidence: 99%

“… 1 Nrf2/ARE signaling pathway is the most important endogenous defense system protecting nerve cells against oxidative damage. 2 Some natural products derived from terrestrial plants, such as britanin, 3 swertiamain, 4 and dl-3- n -butylphthalide, 5 have proven to be able to prevent and mitigate CIRI by activating Nrf2 and enhancing antioxidant gene expression in the preclinical studies. However, the potential of marine natural products as novel neuroprotective antioxidants against CIRI has been rarely studied yet.…”

mentioning

confidence: 99%

Antioxidant and Neuroprotective Xenicane Diterpenes from the Brown Alga Dictyota coriacea

Liu

Chen

et al. 2023

ACS Omega

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Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway

Cited by 25 publications

References 39 publications

Acupoint catgut embedding improves learning and memory impairment in vascular dementia rats

Acupoint catgut embedding improves learning and memory impairment in vascular dementia rats

Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

Antioxidant and Neuroprotective Xenicane Diterpenes from the Brown Alga Dictyota coriacea

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