DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database

Katase, Naoki; Nishimatsu, Shin-ichiro; Yamauchi, Akira; Okano, Shinji; Fujita, Shuichi

doi:10.1016/j.job.2023.09.002

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Dkk-3 Has a Dual Role In Cancer As Either A Tumor Suppressor...1

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2023

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“…DKK-3 stimulates processes that contribute to malignancy, which include cell-autonomous effects on cell proliferation, migration and invasion. High-level expression of DKK-3 is associated with chemoresistance and tumor volume progression in HNSCC [ 56 , 58 ], pancreatic [ 57 ] and esophageal cancer [ 10 ], and with poorer outcomes in HNSCC and esophageal cancer patients [ 10 , 70 ].…”

Section: Dkk-3 Has a Dual Role In Cancer As Either A Tumor Suppressor...mentioning

confidence: 99%

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Mourtada,

Thibaudeau,

Wasylyk

et al. 2023

Cells

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The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this review, we comprehensively describe the known functions of DKK-3 and highlight the importance of context in understanding and exploiting its roles in health and disease.

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Section: Dkk-3 Has a Dual Role In Cancer As Either A Tumor Suppressor...mentioning

confidence: 99%

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Mourtada,

Thibaudeau,

Wasylyk

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database

Cited by 1 publication

References 60 publications

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

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