Djhsp90s are crucial regulators during planarian regeneration and tissue homeostasis

Dong, Zimei; Chu, Gengbo; Sima, Yingxu; Chen, Guangwen

doi:10.1016/j.bbrc.2018.03.047

Cited by 11 publications

(9 citation statements)

References 37 publications

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“…Autophagy is a vital metabolic process for the degradation of senescent or damaged proteins and organelles into amino acids and fatty acids for energy production and recycling (Catana et al., 2018; Wang et al., 2018c). It is activated in response to nutrient starvation or metabolic stress for the maintenance of tissue functions and homeostasis (Dong et al., 2018). It has been demonstrated that basal autophagy is vital for the maintenance of normal cardiac functions (Zhang et al., 2018b).…”

Section: Introductionmentioning

confidence: 99%

The Role of Autophagy in Acute Myocardial Infarction

Wu¹,

Zhang²,

2019

Front. Pharmacol.

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Acute myocardial infarction refers to a sudden death of cardiomyocytes, which leads to a large mortality worldwide. To attenuate acute myocardial infarction, strategies should be made to increase cardiomyocyte survival, improve postinfarcted cardiac function, and reverse the process of cardiac remodeling. Autophagy, a pivotal cellular response, has been widely studied and is known to be involved in various kinds of diseases. In the recent few years, the role of autophagy in diseases has been drawn increasing attention to by researchers. Here in this review, we mainly focus on the discussion of the effect of autophagy on the pathogenesis and progression of acute myocardial infarction under ischemic and ischemia/reperfusion injuries. Furthermore, several popular therapeutic agents and strategies taking advantage of autophagy will be described.

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Section: Introductionmentioning

confidence: 99%

The Role of Autophagy in Acute Myocardial Infarction

Wu¹,

Zhang²,

2019

Front. Pharmacol.

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“…The products of autophagy, basic new nutrients, such as lipids, amino acids, and sugars, are then transported into the cytoplasm, where they are used as a source of energy [ 36 ]. It is activated by starvation or metabolic stress for the maintenance of tissue functions and homeostasis [ 37 ]. Moreover, mitophagy, selective mitochondrial autophagy, is the only intracellular degradative mechanism for removing damaged mitochondria and their harmful ROS [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic activation of cardiac Atg-5 and pancreatic Atg-7 by intermittent fasting alleviates acute myocardial infarction in old rats

et al. 2022

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Background Aging is associated with cardiovascular and metabolic changes, increasing the susceptibility to acute myocardial infarction (AMI). Intermittent fasting (IF) has a beneficial effect on the age-associated cardiovascular diseases. The present study was planned to investigate the possible protective effect of IF against acute AMI induced by isoproterenol (ISO) in old rats and its possible underlying mechanisms mediated by heart and pancreatic autophagy. Thirty Male Wistar rats were divided into four groups: adult; old; Old-ISO (rats subjected to AMI by ISO) and Old-F-ISO groups (rats were subjected to IF for 4 weeks and AMI by ISO). Results IF significantly increased the mRNA expression of cardiac Atg-5 and pancreatic Atg-7 in Old-F-ISO versus old and adult groups. This was associated with a significant decrease in serum troponin-I, serum creatine kinase (CK-MB), cardiac malondialdehyde and cardiac TNF-α, fasting plasma glucose, and HOMA-IR in Old-F-ISO compared to Old-ISO group. Also, IF significantly decreased the age-related overall and visceral obesity in Old-F-ISO versus old and Old-ISO groups. Histological studies revealed attenuation of the local inflammatory response in Old-F-ISO versus Old-ISO group. Pancreatic Atg-7 and heart Atg-5 were significantly increased in Old-ISO versus old rats. Conclusions IF protects against acute AMI in old rats, possibly, via chronic activation of heart Atg-5 and pancreatic Atg-7, and alleviation of age-related overall and visceral obesity. Thus, IF could be a dietary lifestyle modification for attenuation of the susceptibility to acute AMI in aged population. On the other hand, acute activation of heart and pancreatic autophagy by ISO might augment cardiac injury.

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“…Autophagy is an essential metabolic process where aging or damaged proteins and organelles are broken down into amino acids and fatty acids for energy generation and recycling ( Cǎtanǎ et al, 2018 ). These metabolic processes are activated during nutrient deficiency or metabolic stress to maintain tissue function and dynamic balance ( Dong et al, 2018 ). It has been proved that autophagy is essential for maintaining normal heart function ( Zhang Q. Y. et al, 2018 ).…”

Section: Autophagymentioning

confidence: 99%

Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion

Iroegbu

Peng³

et al. 2021

Front. Cell Dev. Biol.

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Cardiovascular disease (CVD) is the leading cause of death in the global population, accounting for about one-third of all deaths each year. Notably, with CVDs, myocardial damages result from myocardial infarction (MI) or cardiac arrhythmias caused by interrupted blood flow. Significantly, in the process of MI or myocardial ischemic-reperfusion (I/R) injury, both regulated and non-regulated cell death methods are involved. The critical factor for patients’ prognosis is the infarct area’s size, which determines the myocardial cells’ survival. Cell therapy for MI has been a research hotspot in recent years; however, exosomes secreted by cells have attracted much attention following shortcomings concerning immunogens. Exosomes are extracellular vesicles containing several biologically active substances such as lipids, nucleic acids, and proteins. New evidence suggests that exosomes play a crucial role in regulating cell death after MI as exosomes of various stem cells can participate in the cell damage process after MI. Hence, in the review herein, we focused on introducing various cell-derived exosomes to reduce cell death after MI by regulating the cell death pathway to understand myocardial repair mechanisms better and provide a reference for clinical treatment.

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Djhsp90s are crucial regulators during planarian regeneration and tissue homeostasis

Cited by 11 publications

References 37 publications

The Role of Autophagy in Acute Myocardial Infarction

The Role of Autophagy in Acute Myocardial Infarction

Chronic activation of cardiac Atg-5 and pancreatic Atg-7 by intermittent fasting alleviates acute myocardial infarction in old rats

Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion

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