Divorce or end of cohabitation among Danish women evaluated for fertility problems

Kjær, Trille Kristina; Albieri, Vanna; Jensen, Allan; Kjær, Susanne K.; Johansen, Christoffer; Dalton, Susanne Oksbjerg

doi:10.1111/aogs.12317

Cited by 33 publications

(36 citation statements)

References 27 publications

(30 reference statements)

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“…Resorting to this procedure has several disadvantages, as it is invasive, carries health risks (4), is expensive and has a limited success rate. Repeated IVF failures are a substantial source of emotional distress, and failure to conceive offspring is a substantial source of relationship breakdown (5).…”

Section: Introductionmentioning

confidence: 99%

NAD⁺repletion rescues female fertility during reproductive ageing

Bertoldo

Listijono

et al. 2019

Preprint

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2Female infertility is a common and devastating condition with life-long health, emotional and 3 social consequences. There is currently no pharmacological therapy for preserving oocyte 4 quality during aging, which is the strongest risk factor for infertility. This leads to an age 5 dependent decline in natural conception and IVF success rates (1). Here, we show that this is 6 due in part to declining levels of the metabolic cofactor nicotinamide adenine dinucleotide 7 (NAD + ), and that restoring NAD + levels with its metabolic precursor nicotinamide 8 mononucleotide (NMN) rejuvenates oocyte quality and quantity in aged animals, leading to 9 improved fertility. These benefits extend to the developing embryo, where NMN 10 supplementation in embryo culture media following IVF enhances blastocyst formation in 11 older mice. The NAD + dependent deacylase SIRT2 is sufficient, but not essential, to 12 recapitulate the benefits of in vivo NMN treatment, and transgenic overexpression of SIRT2 13 maintains oocyte spindle assembly, accurate chromosome segregation, decreased oxidative 14 stress and overall fertility with ageing. Pharmacological elevation of NAD + may be an 15 effective, non-invasive strategy for restoring and maintaining female fertility during ageing, 16 and for improving the success of IVF.17 18 19 risks (4), is expensive and has a limited success rate. Repeated IVF failures are a substantial 1 source of emotional distress, and failure to conceive offspring is a substantial source of 2 relationship breakdown (5). 4The rate-limiting factors for successful pregnancies in IVF are oocyte quantity and quality, 5 both of which start to decline from the middle of the third decade of life in humans (1, 3). 6 Despite the enormous need, there are no clinically viable strategies to either preserve or 7 rejuvenate oocyte quantity or quality during ageing. There is a major need in reproductive 8 medicine for a non-invasive, pharmacological treatment to maintain or restore oocyte quantity 9 and/or quality during ageing. The effect of such a therapy would be to alleviate a rate-limiting 10 barrier to IVF success, or increase the chances of unaided conception, without having to resort 11 to IVF. 12 13The molecular basis for the decline in oocyte quality with advancing age is not clear but is 14 certainly multifactorial. The key factors thought to be involved include genome instability, 15 reduced mitochondrial bioenergetics, increased reactive oxygen species (ROS), and impaired 16 fidelity during meiotic chromosome segregation due to disrupted spindle assembly and 17 compromised function of the spindle assembly checkpoint (SAC) surveillance system (6). This 18 latter hypothesis is evidenced by an increased rate of aneuploidy in embryos with increased 19

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Section: Introductionmentioning

confidence: 99%

NAD⁺repletion rescues female fertility during reproductive ageing

Bertoldo

Listijono

et al. 2019

Preprint

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“…Gelingt rasch eine Schwangerschaft mit Hilfe von In-vitro-Fertilisation, ist die Art der Entstehung des Kindes bald vergessen und Langzeitstudien zeigen keine Unterschiede hinsichtlich Lebensqualität und Kohärenzgefühl zwischen Familien, deren Kinder spontan empfangen und denen, die durch In-vitro-Fertilisation gezeugt wurden (Hogström et al 2012 (Kjaer et al 2014).…”

Section: Belastungen Im Rahmen Der Infertilitätsbehandlung Mit Eigeneunclassified

Psychosoziale Aspekte in der Fortpflanzungsmedizin/ Psychosocial factors in reproductive medicine

Lampe¹,

Schüßler

2015

Zeitschrift für Psychosomatische Medizin und Psychotherapie

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Summary Psychosocial factors in reproductive medicineIntroduction: Since the development of assisted reproduction technology in the 1970s, assisted reproduction has become increasingly used by couples for various reasons. Concurrently, the diagnostic possibilities regarding the health of the unborn child have been elaborated. Methods/Results: The present literature review describes and discusses the possibilities of assisted reproduction (in-vitro fertilization (IVF), intracytoplasmic sperm injection ICSI, cryopreservation, conception of children with the help of a third person) with respect to their psychosocial meaning for those affected and for the children conceived in this manner. The psychological strain pairs experience in the context of prenatal diagnostics and the resulting decisions are illustrated by a case study. Conclusions:The continued progression in the possibilities and resulting conflicts and decision-making processes in reproductive medicine confronts clinicians and psychosomatic/psychotherapeutic practitioners with many new challenges. In conclusion clinical recommendations for the psychosocial counseling of couples are given.

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“…Infertility remains a threat to successful reproduction by couples desirous of pregnancy [1,2]. Its problems are multidimensional and can impose profound physical, psychological and social strains on both partners in a couple [1][2][3][4]. The childless infertile women stand out as being vulnerable to the detrimental consequences of infertility [4].…”

Section: Introductionmentioning

confidence: 99%

Patterns and Management Challenges of Infertility in a LowResource Setting: A Prospective Cohort Study

2019

ARC Journal of Gynecology and Obstetrics

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However, the incidence varies from one region of the world to the other, being highest in the socalled infertility belt Abstract Objectives: To determine patterns and treatment outcomes of infertility among couples presenting with infertility in low-resource setting.Methods: A prospective cohort study of infertile women managed at Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria over a one-year period. Couples were followed up for a minimum of one year. Primary outcome measures were type/cause of infertility and conception rate. Univariate logistic regression was used to analyze data. Statistical significance was accepted when P-value is <0.05.Results: During the study, 126 of 419 new patients managed were cases of infertility, giving an incidence of 30.1%. Mean duration of infertility was 4.1±3.9years. The ratio of primary to secondary infertility was 1:3, and maternal age, socio-economic status and infertility duration did not significantly influence the type of infertility (p>0.05). Up to 55.6% (70/126) women had prior usage of herbal concoctions for infertility and was significantly influenced by infertility duration (p<0.001). Conception rate was significantly more following ovulation factor infertility (p< 0.001). Up to 29.3% of couples achieved pregnancy within one-year follow-up. Conclusion:The ratio of primary to secondary infertility was 1:3. Women with secondary infertility had significantly more conception rate. Overall, conception rate of 29.3% were achieved within one year of follow-up.

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Divorce or end of cohabitation among Danish women evaluated for fertility problems

Abstract: Parity after a fertility evaluation may be an important component in the longitudinal relationships of couples with fertility problems. Studies with detailed information on marital quality and relational well-being of couples with fertility problems are needed.

Cited by 33 publications

References 27 publications

NAD⁺repletion rescues female fertility during reproductive ageing

NAD⁺repletion rescues female fertility during reproductive ageing

Psychosoziale Aspekte in der Fortpflanzungsmedizin/ Psychosocial factors in reproductive medicine

Patterns and Management Challenges of Infertility in a LowResource Setting: A Prospective Cohort Study

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Divorce or end of cohabitation among Danish women evaluated for fertility problems

Abstract: Parity after a fertility evaluation may be an important component in the longitudinal relationships of couples with fertility problems. Studies with detailed information on marital quality and relational well-being of couples with fertility problems are needed.

Cited by 33 publications

References 27 publications

NAD+repletion rescues female fertility during reproductive ageing

NAD+repletion rescues female fertility during reproductive ageing

Psychosoziale Aspekte in der Fortpflanzungsmedizin/ Psychosocial factors in reproductive medicine

Patterns and Management Challenges of Infertility in a LowResource Setting: A Prospective Cohort Study

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NAD⁺repletion rescues female fertility during reproductive ageing

NAD⁺repletion rescues female fertility during reproductive ageing