Abstract. The hypothesis is advanced that the functional urethral obstruction found in neuropathic states is due, in part at least, to urethral supersensitivity following sym pathetic decentralisation.A simple postural test for this condition is described. By its use it has been shown that urethral denervation occurs not only in disorders of the central nervous system but with peripheral damage such as may result from rectal excision and hysterectomy.In some cases with functional urethral obstruction, attributable to supersensitivity of the urethra, no neurological abnormality has been found. These may be examples of localised visceral neuropathy.Key words: Neuropathic urethra; Urethral supersensitivity test; Urethral obstruction.BLADDER function reflects the relationship between intravesical pressure and urethral resistance. In disorders of the nervous system poor bladder emptying is more often due to urethral obstruction than to subnormal voiding pressures. The bladder, however, was almost exclusively the focus of attention in these cases until less than 50 years ago. Then Watkins (1936) reported finding obstruction at the level of the membranous urethra in patients with lesions of the sacral segments. Internal membranous urethrotomy (loosely called 'external sphincterotomy') was introduced for the relief of these cases (Ross et ai., 1957), and whilst it proved effective, the mechanism of the obstruction was obscure (Gibbon, 1973).About the same time Emmett et ai. (1948) noted the common occurrence of membranous urethral obstruction in spastic paraplegics and suggested its relief by subarachnoid alcohol block, sacral rhizotomy or pudendal neurectomy on the assumption that contraction of the striated muscle of the urethra or pelvic floor was responsible. Electromyography has given some support to this concept (Diokno et al., 1974). Rhizotomy, whether chemical or surgical, gave effective relief and the accompanying loss of reflex bladder activity could be compensated for, except in cervical lesions, by abdominal straining or manual compression. Unfortunately, the inevitable impotence produced by sacral rhizotomy was unacceptable to many patients, and pudendal neurectomy as an alternative therefore had a vogue. This operation proved unreliable, however, which is not surprising in view of the repeated demonstration that the internal pudendal nerves do not supply the external urethral sphincter (Gil-Vernet, 1964; Donker et ai., 1976). On the other hand, impotence was an unexpectedly common complication and one which has not even yet been adequately explained. Iilternal membranous urethrotomy, aimed at dividing the striated urethral sphincter, has now become firmly established as the procedure of choice for these cases (Ross et ai., 1976) as well as for the sacral segment cases for whom the operation was originally described.The mechanism of neuropathic urethral obstruction, particularly in conus
222PARAPLEGIA lesions, has been the subject of research at Southport for the past 30 years. An obvious clue was the trad...