Diving into the mammalian swamp of respiratory rhythm generation with the bullfrog

Baghdadwala, Mufaddal I.; Duchcherer, Maryana; Trask, William M.; Gray, Paul A.; Wilson, Richard J. A.

doi:10.1016/j.resp.2015.09.005

Cited by 18 publications

(15 citation statements)

References 112 publications

(154 reference statements)

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“…From an evolutionary perspective, it has been hypothesized that, as breathing evolved from buccal/brachial ventilation to aspiration-driven ventilation, additional oscillatory networks located more caudally and closer to the cranial nerves became involved in rhythm generation (Figure 3) [14 •• ,25 • ]. In mammals, we hypothesize that the three phases of breathing evolved through the recruitment of separate excitatory rhythmogenic micro-circuits in the medulla.…”

Section: Coupled Oscillators In Respiratory Rhythmogenesis and Their mentioning

confidence: 90%

“…For the buccal rhythm generating network in bullfrogs, a sensitivity to changes in chloride-dependent conductances has been demonstrated [14 •• ], but the exact role of inhibition remains unclear. In lamprey, respiratory frequency is controlled by inhibition, but like mammalian respiratory microcircuits, inhibition is not necessary for rhythmogenesis [16].…”

Section: Rhythm Generating Network and The Role Of Synaptic Inhibitionmentioning

confidence: 99%

“…In lamprey, the respiratory rhythm generator is located in the pons, in the so-called para-trigeminal respiratory group (pTRG) (Figure 3a). This differs from the respiratory rhythm-generating network of dogfish, carp and tench that seems to span the length of the brainstem [14 •• ] including medullary regions. Evidence for a localized microcircuit comes from bullfrogs: the gill/buccal rhythmogenic network is located in rhombomere 7/8, similar to the preBötC [14 •• ].…”

Section: Coupled Oscillators In Respiratory Rhythmogenesis and Their mentioning

confidence: 99%

“…This differs from the respiratory rhythm-generating network of dogfish, carp and tench that seems to span the length of the brainstem [14 •• ] including medullary regions. Evidence for a localized microcircuit comes from bullfrogs: the gill/buccal rhythmogenic network is located in rhombomere 7/8, similar to the preBötC [14 •• ]. However, a fundamental problem in assessing homology is that some markers that define the preBötC, such as somatostatin, are not conserved among different vertebrate species [90].…”

Section: Coupled Oscillators In Respiratory Rhythmogenesis and Their mentioning

confidence: 99%

“…Thus, understanding rhythmogenesis is a core issue in neuroscience. Rhythmogenesis can be studied in microcircuits isolated from invertebrates [5,6], mammalian [7 • ,8 • ,9,10,11 • ,12], and non-mammalian vertebrates [13,14 •• ,15 • ,16] as well as fully integrated behavioral systems [17 •• ,18–20,21 • ,22,23]. Yet, the quest to unravel the mechanisms underlying rhythmogenesis has been a difficult journey.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Ramirez

Dashevskiy²,

Marlin³

et al. 2016

Current Opinion in Neurobiology

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Rhythmicity is critical for the generation of rhythmic behaviors and higher brain functions. This review discusses common mechanisms of rhythm generation, including the role of synaptic inhibition and excitation, with a focus on the mammalian respiratory network. This network generates three phases of breathing and is highly integrated with brain regions associated with numerous non-ventilatory behaviors. We hypothesize that during evolution multiple rhythmogenic microcircuits were recruited to accommodate the generation of each breathing phase. While these microcircuits relied primarily on excitatory mechanisms, synaptic inhibition became increasingly important to coordinate the different microcircuits and to integrate breathing into a rich behavioral repertoire that links breathing to sensory processing, arousal, and emotions as well as learning and memory.

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Section: Coupled Oscillators In Respiratory Rhythmogenesis and Their mentioning

confidence: 90%

Section: Rhythm Generating Network and The Role Of Synaptic Inhibitionmentioning

confidence: 99%

Section: Coupled Oscillators In Respiratory Rhythmogenesis and Their mentioning

confidence: 99%

Section: Coupled Oscillators In Respiratory Rhythmogenesis and Their mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Ramirez

Dashevskiy²,

Marlin³

et al. 2016

Current Opinion in Neurobiology

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Control of Breathing in Ectothermic Vertebrates

Milsom

Gilmour

Perry

et al. 2022

Comprehensive Physiology

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Developmental Maturation of Functional Coupling Between Ventilatory Oscillators in the American Bullfrog

Trask

Baghdadwala

Wilson

2018

Developmental Neurobiology

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Many vital motor behaviors – including locomotion, swallowing, and breathing – appear to be dependent upon the activity of and coordination between multiple endogenously rhythmogenic nuclei, or neural oscillators. Much as the functional development of sensory circuits is shaped during maturation, we hypothesized that coordination of oscillators involved in motor control may likewise be maturation‐dependent, i.e., coupling and coordination between oscillators change over development. We tested this hypothesis using the bullfrog isolated brainstem preparation to study the metamorphic transition of ventilatory motor patterns from early rhythmic buccal (water) ventilation in the tadpole to the mature pattern of rhythmic buccal and lung (air) ventilation in the adult. Spatially distinct oscillators drive buccal and lung bursts in the isolated brainstem; we found these oscillators to be active but functionally uncoupled in the tadpole. Over the course of metamorphosis, the rhythms produced by the buccal and lung oscillators become increasingly tightly coordinated. These changes parallel the progression of structural and behavioral changes in the animal, with adult levels of coupling arising by the metamorphic stage (forelimb eruption). These findings suggest that oscillator coupling undergoes a maturation process similar to the refinement of sensory circuits over development.

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Diving into the mammalian swamp of respiratory rhythm generation with the bullfrog

Cited by 18 publications

References 112 publications

Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Control of Breathing in Ectothermic Vertebrates

Developmental Maturation of Functional Coupling Between Ventilatory Oscillators in the American Bullfrog

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