Diverticular Disease in Patients with Chronic Renal Failure Due to Polycystic Kidney Disease

Scheff, Robert T; Zuckerman, Gary R.; Harter, Herschel R.; Delmez, James A.; Koehler, Robert E.

doi:10.7326/0003-4819-92-2-202

Cited by 196 publications

(74 citation statements)

References 10 publications

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“…This disorder is characterized by both renal and extra-renal manifestation (1,2). Colonic diverticulosis has been reported as a common manifestation of an extra-renal gastrointestinal tract complication (3). In addition, ileus has come to be recognized as one of the gastrointestinal complications of ADPKD (4).…”

Section: Introductionmentioning

confidence: 99%

Autosomal Dominant Polycystic Kidney Disease Showing Rupture of a Lateral Ventral Hernia Following Paralytic Ileus

Kato¹,

Ubara²,

Tagami³

et al. 2005

Intern. Med.

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We report an 83-year-old Japanese male with autosomal dominant polycystic kidney disease (ADPKD), which was marked by unusually enlarged kidneys, and in whom ileus occurred after administration of procainamide. The bowels became swollen and ruptured the skin and appeared on the outside of the skin. Even after the ileus state was resolved, the projected intestinal tract was not restored due to a large defect of the skin, and ostomy was performed. Abdominal hernia including lateral ventral hernia due to enlarged kidneys may result in perforation of the abdominal wall as well as intestinal wall.

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Section: Introductionmentioning

confidence: 99%

Autosomal Dominant Polycystic Kidney Disease Showing Rupture of a Lateral Ventral Hernia Following Paralytic Ileus

Kato¹,

Ubara²,

Tagami³

et al. 2005

Intern. Med.

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“…CoffinLowry syndrome is a maternally inheritable disorder that may also be related to disrupted collagen metabolism [88] . Scheff et al [91] observed colonic diverticulae in 83% of patients with end stage polycystic kidney disease (PKD). PKD is due to mutations in the PKD1 or PKD2 genes coding for the cell membrane-bound polycystin proteins.…”

Section: The Role Of Genetics In Ddmentioning

confidence: 99%

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane¹,

Arasaradnam²,

Mills³

et al. 2009

WJG

116

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Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.

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“…[9][10][11][12][13] Various studies reported that the prevalence of colonic diverticulosis is significantly higher in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population or patients on dialysis for other renal diseases. 4,[14][15][16][17][18] Prevalence rates vary from 53.5% to 83%, with the condition attributed to a congenital colonic defect or the secretory action from the renal cysts on the colonic wall. 8 However, the extent of colonic diverticulitis and perforation does not seem to correlate with the primary renal disease.…”

Section: Discussionmentioning

confidence: 99%

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Kakavia

Moris²,

Karatza³

et al. 2016

Exp Clin Transplant

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Results: One patient died from septic shock before any surgery, and 3 patients died during the early postoperative period, resulting in a morality rate of 36.3%. All patients who died had a functioning graft. From the patients who were discharged, the mean follow-up was 16 months (range, 4-32 months). Conclusions: Intestinal perforation after renal transplant is a major and potentially lethal complication. Clinical presentation is usually equivocal, and the transplant surgeon should be highly suspicious when treating a renal transplant recipient with acute abdominal pain, even in cases without other predisposing factors (diverticulitis, ischemic colitis, and so forth), so that this condition could be investigated and unmasked.

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Diverticular Disease in Patients with Chronic Renal Failure Due to Polycystic Kidney Disease

Cited by 196 publications

References 10 publications

Autosomal Dominant Polycystic Kidney Disease Showing Rupture of a Lateral Ventral Hernia Following Paralytic Ileus

Autosomal Dominant Polycystic Kidney Disease Showing Rupture of a Lateral Ventral Hernia Following Paralytic Ileus

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

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