Diverticular disease and migration – the influence of acculturation to a Western lifestyle on diverticular disease

Hjern, Fredrik; Johansson, Claes; Mellgren, Anders; Baxter, Nancy N.; Hjern, Anders

doi:10.1111/j.1365-2036.2006.02805.x

Cited by 126 publications

(70 citation statements)

References 20 publications

(23 reference statements)

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“…5,6 It is highly prevalent in western countries, but is rarely encountered in the developing world. 7,8 The risk of acquiring the disease increases uniformly with age, with approximately 40% of people aged over 60 years being affected in western countries. 9 Although most people with colonic diverticulosis remain asymptomatic, about 25% will eventually present with an episode of acute diverticulitis (the principal inflammatory complication of diverticulosis); of these, 15% will develop other significant and often serious complications such as abscess, fistula or perforation.…”

Section: Introductionmentioning

confidence: 99%

Review article: the current and evolving treatment of colonic diverticular disease

Tursi

Papagrigoriadis

2009

Aliment Pharmacol Ther

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Section: Introductionmentioning

confidence: 99%

Review article: the current and evolving treatment of colonic diverticular disease

Tursi

Papagrigoriadis

2009

Aliment Pharmacol Ther

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“…For example, "non western" immigrants showed a lower risk of DD-related hospital admissions and death but after adjusting for age, risk increased with years of residence in Sweden [13] . In contrast, other studies found no changes in DD incidence amongst migrant communities following periods of naturalization in countries with high or low risk DD in the native population.…”

Section: Epidemiology and Public Health Impactmentioning

confidence: 99%

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane¹,

Arasaradnam²,

Mills³

et al. 2009

WJG

116

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Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.

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“…Diverticulosis increases with age; it is estimated less than 10% in those under the age of 40 and increases to 65-70% in those above 65 years of age [3][4][5]. Besides diverticulosis, the prevalence of colon cancer is also increasing in the western world [3,6]. Colorectal cancer is a leading cause of cancer mortality in the Western world, with more than 1,000,000 new cases per year and with 500,000 deaths per year worldwide [7].…”

Section: Introductionmentioning

confidence: 99%

Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies

Meurs-Szojda

Droste

Kuik

et al. 2008

Int J Colorectal Dis

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Background and aims There are conflicting data concerning the association between diverticular disease and colorectal carcinoma (CRC). This study was performed to determine the prevalence and association of diverticulosis, diverticulitis, polyps, and CRC. Materials and methods In a cross-sectional, retrospective study, we analyzed the colonoscopy reports of complete colonoscopies and patho-histological results of all patients referred for colonoscopy in a period of 3 months in 18 hospitals in The Netherlands. Diverticulosis was defined as three or more diverticula present and diverticulitis as diverticulosis with inflammation. Polyps were also coded according to localization and size. Advanced neoplastic lesions were defined as polyps ≥10 mm in diameter and/or villous architecture and/or adenomas with high grade dysplasia and/or invasive cancer. Actual and previous described CRC were registered. Results A total of 4,241 patients were included in the study [1,996 (47%) male], mean age of 59 and range 18-95. Diverticula, diverticulitis, and polyps were seen in 1,052 (25%), 75 (2%), and 1,282 (30%) patients, respectively. No association was found between patients with polyps and those with and without diverticulosis (p=0.478). Invasive adenocarcinoma and adenomas ≥10 mm were most frequently observed. CRC was present in 372 (9%) patients. Negative relation between diverticulosis and CRC and invasive adenocarcinoma was observed. No association was found between polyps and CRC and patients with diverticulitis and CRC. In conclusion, there is no relation between patients with diverticulosis and higher incidence of polyps or CRC when using age-stratified analysis. No increased risk for polyps or CRC was found in patients with diverticulitis.

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Diverticular disease and migration – the influence of acculturation to a Western lifestyle on diverticular disease

Abstract: SUMMARY BackgroundDiverticular disease of the colon is more common in the Western world, compared with non-Western countries.

Cited by 126 publications

References 20 publications

Review article: the current and evolving treatment of colonic diverticular disease

Review article: the current and evolving treatment of colonic diverticular disease

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies

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