Diversity study of 12 <scp>X</scp>‐chromosomal <scp>STR</scp> loci in <scp>H</scp>ui ethnic from <scp>C</scp>hina

Meng, Hao-Tian; Han, Juntao; Zhang, Yu-Dang; Liu, Wenjuan; Wang, Tianju; Yan, Jiangwei; Huang, Jun; Du, Weian; Guo, Jianxin; Wang, Hongdan; Zhang, Yuhong; Zhou, Ruhua; Zhu, Bofeng; Wei, Xing

doi:10.1002/elps.201400045

Cited by 16 publications

(14 citation statements)

References 41 publications

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“…However, autosomal STRs may not be effective in some deficiency paternity cases, such as the father–daughter testing that the DNA of mother is not available, and the full sisters or paternal sisters testing that the DNA of their biological father is not available. X‐chromosomal STRs were proved to be effective in these cases , because one of two X‐chromosomes of daughter is certainly inherited from her biological father and the sisters share the same paternal X‐chromosome. However, only several studies were reported with some available multiplex amplification systems, including Mentype® Argus X‐8 kit (Biotype AG, Dresden, Germany), Investigator Argus X‐12 (Qiagen, Hilden, Germany) and ZJGA‐X12 STR kit (AGCU ScienTech, Wuxi, Jiangsu, China) in the past .…”

Section: Introductionmentioning

confidence: 99%

Allele and haplotype diversity of new multiplex of 19 ChrX‐STR loci in Han population from Guanzhong region (China)

et al. 2016

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X-chromosomal short tandem repeats (X-STRs) have been proved to be useful for some deficiency paternity cases in recent years. Here, we studied the genetic polymorphisms of 19 X-STR loci (DXS10148-DXS10135-DXS8378, DXS10159-DXS10162-DXS10164, DXS7132-DXS10079-DXS10074-DXS10075, DXS6809-DXS6789, DXS7424-DXS101, DXS10103-HPRTB-DXS10101 and DXS7423-DXS10134) in 252 male and 222 female individuals from Guanzhong Han population, China. No deviation for all 19 loci was observed from the Hardy-Weinberg equilibrium. The polymorphism information content values of the panel of 19 loci were more than 0.5 with the exception of the locus DXS7423. The combined power of discrimination were 0.9999999999999999999994340 in females and 0.9999999999997662 in males, respectively; and the combined mean exclusion chances were 0.999999993764 in duos and 0.999999999997444 in trios, respectively. The haplotype diversities for all the seven clusters of linked loci were more than 0.9. The results showed that the panel of 19 X-STR loci were powerful for forensic applications in Guanzhong Han population. Locus by locus population comparisons showed significant differences at more than seven loci between Guanzhong Han population and the groups from North America, Europe and Africa.

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Section: Introductionmentioning

confidence: 99%

Allele and haplotype diversity of new multiplex of 19 ChrX‐STR loci in Han population from Guanzhong region (China)

et al. 2016

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“…Short tandem repeats (STRs) have become popular DNA markers in forensic DNA labs for more than 20 years and have been proved to possess several benefits, which make them especially suitable to identify victims, perpetrators, missing persons, and for kinship testing and population genetic analysis12345. However, there were some potential limitations of STRs in forensic applications because of its relatively high mutation rate, long amplicon size, and the deficiency in the analysis of highly degraded DNA samples and complex kinship cases.…”

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confidence: 99%

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Shen

Zhu

Yao

et al. 2016

Sci Rep

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In the present study, thirty autosomal insertion and deletion polymorphic loci were simultaneously amplified and genotyped in a multiplex system, and their allelic frequencies as well as several forensic parameters were obtained in a sample of 236 unrelated healthy Tujia individuals. All the loci were in Hardy-Weinberg equilibrium after applying a Bonferroni correction and all pair-wise loci showed no significant linkage disequilibrium. These loci were observed to be relatively informative and discriminating, quite efficient for forensic applications. Allelic frequencies of 30 loci were compared between the Tujia group and other reference populations, and the results of analysis of molecular variance indicated the Tujia group showed the least significant differences with the Shanghai Han at one locus, and the most with Central Spanish population at 22 loci. We analyzed the population genetic structure by the principal component analysis, the clustering of STRUCTURE program and a Neighbor-Joining tree, and then evaluated the genetic relationships among Tujia and other 15 populations.

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“…DXS8378-DXS10148-DXS10135, DXS7132-DXS10079-DXS10075-DXS10074, DXS10103-DXS10101-HPRTB and DXS10134-DXS7423 ( ) were classified as linkage groups 1, 2, 3 and 7, respectively. DXS6809-DXS6789 ( Pasino et al, 2011 ; Szibor et al, 2003a ) was specified as linkage group 4; DXS10159-DXS10162-DXS10164 ( Meng et al, 2014 ; Ye et al, 2014 ) as linkage group 5; and DXS7424-DXS101 ( Edelmann et al, 2002 ; Szibor et al, 2003a ) as linkage group 6. The haplotypic frequencies and haplotypic diversities of the seven linkage groups are shown in Table S3 .…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms and forensic efficiency of 19 X-chromosomal STR loci for Xinjiang Mongolian population

Chen

Guo

Cheng

et al. 2018

PeerJ

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AimX-chromosomal short tandem repeat (X-STR) loci are playing an increasingly important role in some complex kinship cases in recent years. To investigate the forensic efficiency of X-STRs of Mongolian minority group from Xinjiang Uygur Autonomous Region, China, and further depict the genetic relationship among Xinjiang Mongolians and other populations, 267 blood samples from unrelated healthy Xinjiang Mongolians were amplified by an AGCU X-19 STR kit.ResultsNo deviations for all 19 X-STR loci were observed from the Hardy–Weinberg equilibrium after Bonferroni correction (p > 0.0026) in female samples. The most frequent allele was allele 10 at locus DXS10164 with the frequency 0.5663. The polymorphism information content values of the 19 X-STR loci were more than 0.5 with the highest polymorphism at the locus DXS10135. The cumulative power of discrimination were 0.99999999999999999999988761005481 in females and 0.999999999999903 in males, respectively; and the cumulative mean exclusion chances were 0.9999999969738068321121 in duos and 0.999999999998952 in trios, respectively. The seven linkage groups were extremely informative, with all the haplotype diversities greater than 0.9487. No linkage disequilibrium was observed for a significance level of 0.00029 (p = 0.05/171) after Bonferroni correction. The DA distances, multidimensional scaling plot and phylogenetic tree based on the 11 overlapping X-STR loci all presented that the Xinjiang Mongolian population was genetically different from other Asian populations, including the Mongolian population from Inner Mongolia Autonomous Region, China.ConclusionThis study indicated that the 19 X-STR multiplex PCR system was of high utility value for both forensic practices and population genetic research in Xinjiang Mongolian group.

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Diversity study of 12 X‐chromosomal STR loci in Hui ethnic from China

Cited by 16 publications

References 41 publications

Allele and haplotype diversity of new multiplex of 19 ChrX‐STR loci in Han population from Guanzhong region (China)

Allele and haplotype diversity of new multiplex of 19 ChrX‐STR loci in Han population from Guanzhong region (China)

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Genetic polymorphisms and forensic efficiency of 19 X-chromosomal STR loci for Xinjiang Mongolian population

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