Abstract:Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, a direct result of which has been to elucidate novel biological mechanisms of action. Running in parallel to the development of DOS over the past few decades, DNA-encoded libraries (DELs) have emerged as an effective and efficient screening strategy to identify protein binders. Yet, despite recent advancements in this field most DEL syntheses are limited by the pres… Show more
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