Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stocks of Laboratory Mice

Mikaelian, Igor

doi:10.1016/b978-012336425-8/50075-3

Cited by 9 publications

(9 citation statements)

References 15 publications

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“…1,41 Specifically, a high frequency (11%) has been reported for NOD mice, with lower frequency in NOD-derived strains, including a 3% incidence in NSG mice. 28,29 …”

Section: Discussionmentioning

confidence: 99%

Pathology of Aging in NODscidgamma Female Mice

et al. 2017

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In the past decade, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related pathology are not currently available in the literature. The prevalence of spontaneous morbidity affecting aged NSG female breeders enrolled in a parasitology study was documented with classification of neoplastic and non-neoplastic (inflammatory, metabolic, degenerative) lesions. Malignant mammary neoplasms were most commonly diagnosed, often accompanied by pulmonary metastases, while a low frequency of lymphoma and histiocytic sarcoma was documented. The major inflammatory conditions were suppurative pleuropneumonia and bronchopneumonia with abscess formation, from which Pasteurella pneumotropica was commonly isolated, followed by otitis media. Both inflammatory and degenerative lesions of the genital tract were identified, along with neoplasms such as endometrial yolk sac carcinomas and granulosa cell tumors. Novel conditions identified included renal tubular degeneration and necrosis associated with 2 concurrent types of intranuclear inclusions, focal or multifocal hyperostosis of the skull, and neuroendocrine tumors of the mesometrium. The majority of degenerative lesions that affected the genital tract, endocrine, and skeletal systems did not represent the actual underlying cause of death but, rather, were considered incidental findings. This study indicates that both inflammatory and neoplastic conditions contribute to morbidity and mortality in experimentally manipulated aged female NSG mice.

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“…1,41 Specifically, a high frequency (11%) has been reported for NOD mice, with lower frequency in NOD-derived strains, including a 3% incidence in NSG mice. 28,29 …”

Section: Discussionmentioning

confidence: 99%

Pathology of Aging in NODscidgamma Female Mice

et al. 2017

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“…Compared to large studies that aim primarily for incidence or prevalence data or responses to an intervention, involving one or few strains, the MTB database or Pathbase can be mined for frequency data among many strains. 26,154,192 Procedural Considerations (Materials and Methods) relevant to pathology in mouse aging studies. ''For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported.…”

Section: Experimental Designmentioning

confidence: 99%

Pathobiology of Aging Mice and GEM

2012

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The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. Genetic background contributes to pathology phenotypes and to causes of death as well as to longevity. Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. This review aims to provide resources to enhance the design and practice of chronic and longevity studies involving GEM. C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. Resources are included also for pathology of other inbred strain families, including A, AKR, BALB/c, C3H, C57L, C58, CBA, DBA, GR, NOD.scid, SAMP, and SJL/J, and non-inbred mice, including 4WC, AB6F1, Ames dwarf, B6, 129, B6C3F1, BALB/c,129, Het3, nude, SENCAR, and several Swiss stocks. Experimental strategies for long-term cross-sectional and longitudinal studies to assess causes of or contributors to death, disease burden, spectrum of pathology phenotypes, longevity, and functional healthy life spans (health spans) are compared and discussed.

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“…7 Therefore, a comprehensive knowledge of the phenotype of background strains is required, especially as inbred strains differ in their susceptibilities to particular neoplastic and nonneoplastic diseases. 8,25,44,67,73 Furthermore, substrains that arise through prolonged inbreeding within various laboratories can differ significantly from the parent strain. 26 There are abundant data on gross and histological lesions of common strains, but this information is widely dispersed.…”

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confidence: 99%

Neoplastic and Nonneoplastic Lesions in Aging Mice of Unique and Common Inbred Strains Contribution to Modeling of Human Neoplastic Diseases

Szymańska

Lechowska-Piskorowska

Krysiak

et al. 2013

Vet Pathol

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The evaluation of spontaneous lesions in classical inbred strains of mice has become increasingly important because genetically engineered mice (GEMs) are created on these backgrounds. Novel inbred strains-genetically diverse from classic strains-are valuable both as a new background for GEM mice and to increase the genetic variation found in laboratory mice. Newly arising spontaneous genetic alterations in commonly used strains may also lead to new and valuable mouse models of disease. This report evaluates gross and histological lesions in relatively new, classic, and rarely explored mouse inbred strains. Pathological lesions of 1273 mice from 12 inbred strains (129S1/SvW, A.CA-H2

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Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stocks of Laboratory Mice

Cited by 9 publications

References 15 publications

Pathology of Aging in NODscidgamma Female Mice

Pathology of Aging in NODscidgamma Female Mice

Pathobiology of Aging Mice and GEM

Neoplastic and Nonneoplastic Lesions in Aging Mice of Unique and Common Inbred Strains Contribution to Modeling of Human Neoplastic Diseases

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