Diversity of Secondary Metabolites in Roots from Conium maculatum L.

Chizzola, Remigius; Lohwasser, U.

doi:10.3390/plants9080939

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…However, these plants are very toxic (Conium maculatum, colloquially known as hemlock, poison hemlock or wild hemlock, is a highly poisonous biennial herbaceous flowering plant in the carrot family Apiaceae, native to Europe and North Africa) and have many side effects. The optimal dosage form for poisonous plants is an alcohol tincture with a drip dosing regimen (Chizzola and Lohwasser 2020).…”

Section: Gonadotropic Plants For Treatment Fibrocystic Breast Diseasementioning

confidence: 99%

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Sokolik

Prozorova

2022

RRP

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Introduction: Fibrocystic breast disease, commonly called fibrocystic breasts or fibrocystic change, is a benign (noncancerous) condition, which is the most common pathology in women of reproductive age. Treatment of fibrocystic breast disease and concomitant pathologies can involve using herbs. Materials and Methods: To make an analysis of literary sources on the development of fibrocystic breast disease in the pathogenesis of diseases of the female reproductive system (clinical human (75%) and animal studies (25%)) were published in the period of 2017–2021. Results and discussion: The diversity of plants in the world is a promising ground for therapeutic improvisation, allowing for an individual approach to each patient, but, most importantly, creates possibilities for maneuvering in the event of ineffectiveness of any means. In some situations, herbal medicine is not only possible or permissible, but strictly mandatory, and is essentially the only effective therapeutic method, which is relatively safe provided the correct selection of combinations and control by a doctor who applies a certain method of phytotherapy, especially given a duration of treatment. The need for a deeper study is long overdue for the pharmacological capabilities of various plant raw materials in the treatment of not only this pathology, but others as well. Conclusion: The development of phytotherapy should be based primarily on scientific developments, but this area can not be considered the prerogative of only phytotherapists, as herbal medicines should be in the arsenal of doctors of all specialties.

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Section: Gonadotropic Plants For Treatment Fibrocystic Breast Diseasementioning

confidence: 99%

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Sokolik

Prozorova

2022

RRP

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“…The amount of high-value secondary metabolites determines the market price of medicinal materials (Chizzola and Lohwasser 2020). Therefore, improving the quality of medicinal plants by technical means is a very meaningful scienti c research task.…”

Section: Introductionmentioning

confidence: 99%

GlPS1 overexpression accumulates coumarin secondary metabolites in transgenic Arabidopsis

Ren

et al. 2022

Preprint

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The dried root of Glehnia littoralis is a traditional Chinese herbal medicine mainly used to treat lung diseases and plays an important role in fighting coronavirus disease 2019 pneumonia in China. This study focused on the key enzyme gene GlPS1 for furanocoumarin synthesis in G. littoralis. In the 35S:GlPS1 transgenic Arabidopsis study, the Arabidopsis thaliana-overexpressing GlPS1 gene was more salt-tolerant than Arabidopsis in the blank group. Metabolomics analysis showed 30 differential metabolites in Arabidopsis, which overexpressed the GlPS1 gene. Twelve coumarin compounds were significantly upregulated, and six of these coumarin compounds were not detected in the blank group. Among these differential coumarin metabolites, isopimpinellin and aesculetin have been annotated by the Kyoto Encyclopedia of Genes and Genomes and isopimpinellin was not detected in the blank group. Through structural comparison, imperatorin was formed by dehydration and condensation of zanthotoxol and a molecule of isoprenol, and the difference between them was only one isoprene. Results showed that the GlPS1 gene positively regulated the synthesis of coumarin metabolites in A. thaliana and at the same time improved the salt tolerance of A. thaliana.

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“…To sum up, coumarins have very important medical and commercial value in medicinal plants. The amount of high-value secondary metabolites determines the market price of medicinal materials (Chizzola and Lohwasser 2020 ). Therefore, improving the quality of medicinal plants by technical means is a very meaningful scientific research task.…”

Section: Introductionmentioning

confidence: 99%

GlPS1 overexpression accumulates coumarin secondary metabolites in transgenic Arabidopsis

Ren

et al. 2022

Plant Cell Tiss Organ Cult

View full text Add to dashboard Cite

The dried root of Glehnia littoralis is a traditional Chinese herbal medicine mainly used to treat lung diseases and plays an important role in fighting coronavirus disease 2019 pneumonia in China. This study focused on the key enzyme gene GlPS1 for furanocoumarin synthesis in G. littoralis . In the 35S: GlPS1 transgenic Arabidopsis study, the Arabidopsis thaliana -overexpressing GlPS1 gene was more salt-tolerant than Arabidopsis in the blank group. Metabolomics analysis showed 30 differential metabolites in Arabidopsis , which overexpressed the GlPS1 gene. Twelve coumarin compounds were significantly upregulated, and six of these coumarin compounds were not detected in the blank group. Among these differential coumarin metabolites, isopimpinellin and aesculetin have been annotated by the Kyoto Encyclopedia of Genes and Genomes and isopimpinellin was not detected in the blank group. Through structural comparison, imperatorin was formed by dehydration and condensation of zanthotoxol and a molecule of isoprenol, and the difference between them was only one isoprene. Results showed that the GlPS1 gene positively regulated the synthesis of coumarin metabolites in A. thaliana and at the same time improved the salt tolerance of A. thaliana . Supplementary Information The online version contains supplementary material available at 10.1007/s11240-022-02427-w.

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Diversity of Secondary Metabolites in Roots from Conium maculatum L.

Cited by 4 publications

References 38 publications

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

GlPS1 overexpression accumulates coumarin secondary metabolites in transgenic Arabidopsis

GlPS1 overexpression accumulates coumarin secondary metabolites in transgenic Arabidopsis

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