Diversity of Participants in Williams Syndrome Intervention Studies

Shin, Eun-Ju; Ravichandran, Caitlin; Renzi, Danielle; Pober, Barbara R.; McDougle, Christopher J.; Thom, Robyn P.

doi:10.1007/s10803-023-06088-2

Cited by 1 publication

(2 citation statements)

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“…As these interventions are further refined and tested, it will be critical to ensure that the research is conducted with an eye towards scalability and maximizing dissemination potential for a rare genetic syndrome. Additionally, there is a need for increased representation of racial and minority groups, older participants, and more cognitively impaired patients in Williams syndrome clinical research [30]. Based on the available published demographic data, 88% of Williams syndrome participants represented in the extant Williams syndrome clinical trials literature identify as white [30].…”

Section: Future Research Directions and Conclusionmentioning

confidence: 99%

“…Additionally, there is a need for increased representation of racial and minority groups, older participants, and more cognitively impaired patients in Williams syndrome clinical research [30]. Based on the available published demographic data, 88% of Williams syndrome participants represented in the extant Williams syndrome clinical trials literature identify as white [30].…”

Section: Future Research Directions and Conclusionmentioning

confidence: 99%

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Psychiatric and behavioral manifestations of Williams syndrome

Thom

2023

Current Opinion in Psychiatry

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Purpose of review The purpose of this review is to synthesize recent advances in the psychiatric and behavioral manifestations of Williams syndrome, a rare genetic syndrome. Recent advances have focused on more deeply characterizing the social phenotype and developing social skill interventions, improving the assessment and treatment of anxiety, and exploring eating behaviors. Recent findings The social cognitive phenotype in Williams syndrome, which consists of both high social drive and social cognition deficits, is present cross-culturally and may be related to reduced eye gaze. Social skills training for adults with Williams syndrome has demonstrated promise. Adapted exposure therapy and cognitive behavioral therapy programs for children and adults respectively, have been piloted in Williams syndrome. The majority of adults with Williams syndrome are either underweight or overweight, and problematic food-related behaviors likely contribute to bodyweight status. Summary Williams syndrome is associated with a number of core social and psychiatric difficulties which have a significant impact on functioning and quality of life. Recent work has begun to utilize a more nuanced understanding of the clinical presentations of these problems to develop interventions tailored to this unique population. However, larger trials, particularly those inclusive of a more diverse Williams syndrome population, are needed.

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Section: Future Research Directions and Conclusionmentioning

confidence: 99%

Section: Future Research Directions and Conclusionmentioning

confidence: 99%