Diversity of Oral Biofilms in Periodontal Health and Disease

Kumar, Purnima

doi:10.1007/978-3-319-53737-5_2

Cited by 6 publications

(5 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there were no clear compositional differences between the analyzed groups, a certain number of bacterial species within the genera Neisseria and Porphyromonas as well as Prevotella could be associated with pneumonia patients. As these genera are mainly linked to periodontal disease ( 70 , 71 ), this finding may reflect the dental and oral data discussed above, with higher numbers of missing teeth and worse oral hygiene found in the pneumonia patients.…”

Section: Discussionmentioning

confidence: 66%

Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia—A Prospective Observational Study

et al. 2020

View full text Add to dashboard Cite

Stroke-associated pneumonia is a major cause for poor outcomes in the post-acute phase after stroke. Several studies have suggested potential links between neglected oral health and pneumonia. Therefore, the aim of this prospective observational study was to investigate oral health and microbiota and incidence of pneumonia in patients consecutively admitted to a stroke unit with stroke-like symptoms. This study involved three investigation timepoints. The baseline investigation (within 24 h of admission) involved collection of demographic, neurological, and immunological data; dental examinations; and microbiological sampling (saliva and subgingival plaque). Further investigation timepoints at 48 or 120 h after baseline included collection of immunological data and microbiological sampling. Microbiological samples were analyzed by culture technique and by 16S rRNA amplicon sequencing. From the 99 patients included in this study, 57 were diagnosed with stroke and 42 were so-called stroke mimics. From 57 stroke patients, 8 (14%) developed pneumonia. Stroke-associated pneumonia was significantly associated with higher age, dysphagia, greater stroke severity, embolectomy, nasogastric tubes, and higher baseline C-reactive protein (CRP). There were trends toward higher incidence of pneumonia in patients with more missing teeth and worse oral hygiene. Microbiological analyses showed no relevant differences regarding microbial composition between the groups. However, there was a significant ecological shift over time in the pneumonia patients, probably due to antibiotic treatment. This prospective observational study investigating associations between neglected oral health and incidence of SAP encourages investigations in larger patient cohorts and implementation of oral hygiene programs in stroke units that may help reducing the incidence of stroke-associated pneumonia.

show abstract

Section: Discussionmentioning

confidence: 66%

Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia—A Prospective Observational Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Therefore, lactic acid is the boon for reducing exogenous periodontal gram negative species in the gingival sulcus. 8,11 On the other hand lactic acid is also responsible for caries formation. Decrease in the level of gamma amino butyric acid, butyrate and lactate is linked to increased risk for periodontal disease development.…”

Section: Metabolical Changes In the Oral Fluidmentioning

confidence: 99%

Metabolomics in Periodontal Disease - A Mini Review

Siddiqui

Mehrotra

et al. 2022

EDJ

View full text Add to dashboard Cite

Periodontitis is the most common oral disease. It is a chronic disease that is characterised by the destruction of the tissues. It is caused by multifactorial aetiology. Variation in host metabolism and microbes results in the development of periodontitis. Saliva provides us with a protective role of lubrication, neutralizing the pH, mineralising the bones and fighting microbes in a diseased oral cavity. We need to identify metabolites in saliva to know the aetiology and stage of periodontitis. Some metabolites may help in the diagnosis and treatment of periodontitis. Various classes of the biochemicals like amino acids, lipids, carbohydrates, nuclear peptides, dipeptides are changed in periodontitis. Most importantly, there is an increase in the levels of protease, glycosidase and lipase activity in chronic periodontal disease that forms the most favourable time for the growth of bacteria. There is a deficiency in contempered screening methods. Therefore, we should understand the arising need for metabolites for better diagnosis and treatment of periodontitis.

show abstract

“…The oral microbiota constitutes an important part of the human microbiota and implies several hundred diverse species [ 1 , 2 ]. This microbiome is a normal part of the oral cavity and generally protects against colonization of extrinsic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Dental Biofilm and Saliva Microbiome and Its Interplay with Pediatric Allergies

et al. 2021

View full text Add to dashboard Cite

Little is known about the interplay and contribution of oral microorganisms to allergic diseases, especially in children. The aim of the clinical study was to associate saliva and dental biofilm microbiome with allergic disease, in particular with allergic asthma. In a single-center study, allergic/asthmatic children (n = 15; AA-Chd; age 10.7 ± 2.9), atopic/allergic children (n = 16; AT/AL-Chd; 11.3 ± 2.9), and healthy controls (n = 15; CON-Chd; age 9.9 ± 2.2) were recruited. After removing adhering biofilms from teeth and collecting saliva, microbiome was analyzed by using a 16s-rRNA gene-based next-generation sequencing in these two mediums. Microbiome structure differed significantly between saliva and dental biofilms (β-diversity). Within the groups, the dental biofilm microbiome of AA-Chd and AT/AL-Chd showed a similar microbial fingerprint characterized by only a small number of taxa that were enriched or depleted (4) compared to the CON-Chd, while both diseased groups showed a stronger microbial shift compared to CON-Chd, revealing 14 taxa in AA-Chd and 15 taxa in AT/AL-Chd that were different. This could be the first note to the contribution of dental biofilm and its metabolic activity to allergic health or disease.

show abstract

Diversity of Oral Biofilms in Periodontal Health and Disease

Cited by 6 publications

References 69 publications

Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia—A Prospective Observational Study

Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia—A Prospective Observational Study

Metabolomics in Periodontal Disease - A Mini Review

Dental Biofilm and Saliva Microbiome and Its Interplay with Pediatric Allergies

Contact Info

Product

Resources

About