Diversity of Ion Channels in Human Bone Marrow Mesenchymal Stem Cells from Amyotrophic Lateral Sclerosis Patients

Abstract

was also recorded. In the RT-PCR analysis, Kv1.1, heag1, Kv4.2, Kir2.1, M axiK, and hNE-Na were detected. In particular, INa,TTX showed a significant passage-dependent increase. This is the first report showing that functional ion channel profiling depend on the cellular passage of hBM-MSCs

Characterization of ion currents of murine CD117pos stem cells in vitro and their modulation under AT2R stimulation

“…, Park et al . ). In these studies, IK dr and I to , being time and voltage dependent, and IBK Ca were described.…”

Mesenchymal stem cells and acquisition of a bone phenotype: An ion channel overview

“…Furthermore, osteoblasts and osteocytes possess ion channels and channels have different functions. It has been reported that K + and Ca ++ channels have roles in proliferation, differentiation and apoptosis (Tao et al, 2008), in the modulation of the progression of the cell cycle and in affecting the proliferation of MSCs (Wang et al, 2008) (Park et al, 2008). There is a variable expression of K + channel with cell cycle of MSCs and this way contributes to the cell cycle progression.…”

“…profiling may depend on the cellular passage of MSCs (Park et al, 2008 (Zahanich et al, 2005) (Zahanich et al, 2005;Balana et al, 2006;Zeng et al, 2011) (Zahanich et al, 2005) (Zahanich et al, 2005) (Li et al, 2006) (Li et al, 2006Park et al, 2007;Park et al, 2008) (Li et al, 2006;Park et al, 2007) (Park et al, 2007) (Magra et al, 2007) (Magra et al, 2007) (Magra et al, 2007) (Heubach et al, 2004Balana et al, 2006;Park et al, 2007;Bonnet et al, 2008;Park et al, 2008) (Bonnet et al, 2008Wang et al, 2008;Wang et al, 2009;Zeng et al, 2011) (Li et al, 2005Zeng et al, 2011) (Balana et al, 2006;Bonnet et al, 2008) (Zahanich et al, 2005;Bergh et  al., 2006)  (Gu et al, 2001;Zahanich et al, +++ 2005;Bergh et al, 2006)  (Gu et al, 2001;Bergh et al, 2006) …”

“…Kv2.1 Kv2.x Kv2.2 (Li et al, 2005) (Heubach et al, 2004;Bonnet et al, 2008;Wang et al, 2008) (Li et al, 2005) -- (Yellowley et al, 1998) ++ (Yellowley et al, 1998) -- (Yellowley et al, 1998) (Heubach et al, 2004) (Li et al, 2005) (Heubach et al, 2004;Park et al, 2007;Park et al, 2008;Benzhi et al, 2009) (Heubach et al, 2004;Balana et al, 2006;Wang et al, 2008) ++ (Yellowley et al, 1998) ++ (Yellowley et al, 1998) ? (Yellowley et al, 1998) ?…”

Efeito da injeção intratecal de células tronco do cordão umbilical humano na lesão isquêmica da medula espinhal em ratos

“…Outros estudos ressaltaram que a liberação de fatores neurotróficos pelas células enxertadas seriam capazes de promover a remielinização de oligodendrócitos, incrementar a proliferação dos astrócitos e estimular o surgimento de novas fibras nervosas, o que contribuiria para a melhora da função neurológica 17 . Park e colaboradores comprovaram a capacidade das células-tronco embrionárias, e suas derivadas, de produzirem substâncias neuroquimicamente ativas, capazes de mediar a reposta inflamatória e exercer atividade terapêutica nas lesões do sistema nervoso central 20 .…”