Diversity of<i>Helicobacter pylori</i>genotypes in Iranian patients with different gastroduodenal disorders

Vaziri, Farzam; Peerayeh, Shahin Najar; Alebouyeh, Masoud; Mirzaei, Tabassom; Yamaoka, Yoshio; Molaei, Mahsa; Maghsoudi, Nader; Zali, Mohammad Reza

doi:10.3748/wjg.v19.i34.5685

Cited by 39 publications

(27 citation statements)

References 38 publications

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“…The prevalence of the vacA-s1 genotype in IM patients was investigated in six studies. 8,11,[23][24][25][26] The overall prevalence of the vacA-s1 genotype was 79.4% (151/190) in IM patients and 67.2% (309/460) in controls (Supporting Information Table S1). The pooled RR in a random-effects model was 1.418 (95% CI, 1.035-1.942, P = 0.030; Fig.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori vacuolating cytotoxin genotypes and preneoplastic lesions or gastric cancer risk: a meta‐analysis

Abdi

Latifi‐Navid

Latifi-Navid

et al. 2016

J of Gastro and Hepatol

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Section: Introductionmentioning

confidence: 99%

Helicobacter pylori vacuolating cytotoxin genotypes and preneoplastic lesions or gastric cancer risk: a meta‐analysis

Abdi

Latifi‐Navid

Latifi-Navid

et al. 2016

J of Gastro and Hepatol

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“…This pathogen has been categorized as a group I carcinogen by the international agency for research on cancer and its infection occurs more frequently in developing countries than in industrialized countries (1). Colonization in the human stomach commonly leads to gastritis that could progress to ulcer in the duodenum or the stomach.…”

Section: Introductionmentioning

confidence: 99%

Resistance Rate and Minimum Inhibitory Concentration of Metronidazole Among Helicobacter pylori Strains in Tehran, Iran

Mahnaz

Alebouyeh

Farzi

et al. 2016

Arch Clin Infect Dis

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“…Furthermore, there is much concrete evidence which H. pylori virulence factors are essential to express clinical symptoms (20). In addition, it has been proved that CagA is the most important virulence factor in the bacteria, and individuals infected by CagA positive H. pylori are at high risk of developing gastric adenocarcinoma and duodenal ulcer disease (21).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter Pylori and CagA: Relationships With Esophageal and Gastroduodenal Disorders in Iranian Patients

Teymournejad¹,

Shokoohizadeh

Mobarez³

et al. 2015

Int J Enteric Pathog

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Background:The severity of Helicobacter pylori infection is associated with virulence factors of the bacteria and host immune response. H. pylori has several virulence factors which a number of them are essential to emerge clinical outcomes. Cytotoxin-associated gene A (CagA) is the most important H. pylori virulence factor. Objectives: The aim of our study was to assess a significant relationship between presence of cagA and severity of clinical manifestation in esophageal and gastroduodenal disorders. Patients and Methods: A total of 240 gastric biopsies were collected between March 2012 and August 2013 from Tehran's hospitals. Three sets of biopsy specimens were obtained from the antrum and rapid urease tests, histological examination, Polymerase Chain Reaction (PCR) assay were performed on the biopsy specimens. Results: One hundred and eight (45%) of biopsy specimens were positive with rapid urease test and ureC gene PCR. Moreover, thirty eight (35.1%) of positive specimens had cagA gene. The rate of gastric and duodenum inflammation was more in patients who carried CagA positive H. pylori strains. Whereas less inflammation and sever lesions in esophagus were found in CagA negative H. pylori strains. Conclusions: Our study demonstrates a strong relationship between CagA and esophageal and gastroduodenal disorders. The number of CagA negative H. pylori was larger than CagA positive in esophagus lesion grade A, C, and D. Therefore, cagA may have a protective effect on some esophageal diseases. In addition, the number of CagA positives was larger than CagA negative H. pylori in gastric antrum and duodenum ulcer. Thus, CagA play a role to emerge peptic and duodenal ulcers.

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Diversity ofHelicobacter pylorigenotypes in Iranian patients with different gastroduodenal disorders

Abstract: This genotyping panel can be a useful tool for detection of virulent H. pylori isolates and can provide valuable guidance for prediction of the clinical outcomes.

Cited by 39 publications

References 38 publications

Helicobacter pylori vacuolating cytotoxin genotypes and preneoplastic lesions or gastric cancer risk: a meta‐analysis

Helicobacter pylori vacuolating cytotoxin genotypes and preneoplastic lesions or gastric cancer risk: a meta‐analysis

Resistance Rate and Minimum Inhibitory Concentration of Metronidazole Among Helicobacter pylori Strains in Tehran, Iran

Helicobacter Pylori and CagA: Relationships With Esophageal and Gastroduodenal Disorders in Iranian Patients

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