Diversity of enteric and non-enteric human adenovirus strains in Brazil, 2006-2011

Souza, Ellen Viana de; Souza, Yasmin França Viana Pires de; Medeiros, Roberta Salzone; Azevedo, Laís Sampaio de; Queiroz, Talita Gonçalves Aires de; Duro, Rodrigo Lopes Sanz; Marinho, Robson dos Santos Souza; Komninakis, Shirley Vasconcelos; Timenetsky, María do Carmo Sampaio Tavares; Luchs, Adriana

doi:10.1007/s00705-020-04946-3

Cited by 8 publications

(4 citation statements)

References 52 publications

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“…During the first two years of our study, HAdV was detected year-round and no apparent seasonal distribution was observed. These findings are consistent with several long-term studies conducted worldwide, including in Brazil, which did not observe any HAdV seasonal distribution 23 , 29 , 30 . From April to September 2020, we observed a dramatic decrease in the number of AGE reported cases, reflecting the impact of COVID-19 pandemic and non-pharmaceutical preventive measures implemented, such as lockdowns, schools and daycares closure, social distancing, heightened hygiene awareness and wearing masks.…”

Section: Discussionsupporting

confidence: 93%

Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020

Nascimento

Fialho

Andrade

et al. 2022

Sci Rep

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Human adenovirus (HAdV) types F40/41 have long been recognized as major viral agents of acute gastroenteritis (AGE) in children. Despite this, studies on HAdV molecular epidemiology are sparse, and their real impact is likely under-estimated. Thus, our goal was to investigate HAdV incidence, enteric and non-enteric types circulation, co-detections with rotavirus and norovirus and DNA shedding in stool samples from inpatients and outpatients from eleven Brazilian states. During the three-year study, 1012 AGE stool samples were analysed by TaqMan-based qPCR, to detect and quantify HAdV. Positive samples were genotyped by partial sequencing of the hexon gene followed by phylogenetic analysis. Co-detections were accessed by screening for rotavirus and norovirus. Overall, we detected HAdV in 24.5% of single-detected samples (n = 248), with a prevalence of type F41 (35.8%). We observed a higher incidence in children between 6 to 24 months, without marked seasonality. Additionally, we observed a statistically higher median viral load among single-detections between enteric and non-enteric types and a significantly lower HAdV viral load compared to rotavirus and norovirus in co-detections (p < 0.0001). Our study contributes to the knowledge of HAdV epidemiology and reinforces the need for the inclusion of enteric types F40/41 in molecular surveillance programs.

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Section: Discussionsupporting

confidence: 93%

Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020

Nascimento

Fialho

Andrade

et al. 2022

Sci Rep

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“…The AdVs can be considered typical enteric (such as AdV 41) and non-enteric (such as those mainly causing respiratory symptoms). AdV41, as previously observed in other studies, [51][52][53] is the prevalent circulating serotype in the community under study. Interestingly, we also described the presence of other non enteric AdVs belonging to AdVB3, AdVC1 and AdVC2, as already reported in Italy 54 and in other countries 55 Adenovirus species AdV-B of zoonotic origin (types B3, B7, B11, B14, B16, and B21) 56 and AdV-C (types C1, C2, C5, and C6) are commonly associated with acute respiratory illnesses.…”

Section: 1%supporting

confidence: 84%

Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic

Amoroso,

Pucciarelli,

Serra

et al. 2024

Journal of Medical Virology

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Acute gastroenteritis (AGE) represents a world public health relevant problem especially in children. Enteric viruses are the pathogens mainly involved in the episodes of AGE, causing about 70.00% of the cases. Apart from well‐known rotavirus (RVA), adenovirus (AdV) and norovirus (NoV), there are various emerging viral pathogens potentially associated with AGE episodes. In this study, the presence of ten different enteric viruses was investigated in 152 fecal samples collected from children hospitalized for gastroenteritis. Real time PCR results showed that 49.3% of them were positive for viral detection with the following prevalence: norovirus GII 19.7%, AdV 15.8%, RVA 10.5%, human parechovirus (HPeV) 5.3%, enterovirus (EV) 3.3%, sapovirus (SaV) 2.6%. Salivirus (SalV), norovirus GI and astrovirus (AstV) 1.3% each, aichivirus (AiV) found in only one patient. In 38.2% of feces only one virus was detected, while co‐infections were identified in 11.8% of the cases. Among young patients, 105 were ≤5 years old and 56.0% tested positive for viral detection, while 47 were >5 years old with 40.0% of them infected. Results obtained confirm a complex plethora of viruses potentially implicated in gastroenteritis in children, with some of them previously known for other etiologies but detectable in fecal samples. Subsequent studies should investigate the role of these viruses in causing gastroenteritis and explore the possibility that other symptoms may be ascribed to multiple infections.

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“…Viruses are the most important etiologic agents, with rotavirus group A (RVA) being the most frequent cause of AGE ( 2 ). Following the introduction of RVA vaccines in 2006, other enteric viruses have occurred with higher prevalence ( 3 , 4 ) such as human adenoviruses (HAdV) ( 5 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

Nonenteric Adenoviruses Associated with Gastroenteritis in Hospitalized Children

et al. 2021

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Diversity of enteric and non-enteric human adenovirus strains in Brazil, 2006-2011

Cited by 8 publications

References 52 publications

Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020

Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020

Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic

Nonenteric Adenoviruses Associated with Gastroenteritis in Hospitalized Children

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