Diversity of cells and signals in the cardiovascular system

Abstract

support-information-section). Ele Grandi is a Professor in the Department of Pharmacology, the Chair of the Biophysics Graduate Group, and a Chancellor's Fellow at the University of California Davis. Her research utilizes mathematical modelling and simulation as an interpretative and predictive science to investigate the mechanisms of cardiac arrhythmias. Manuel F. Navedo is a Professor in the Department of Pharmacology and the Chair of the Molecular, Cellular and Integrative Physiology Graduate Group at UC Davis. He is an established physiologist and vascular biologist examining mechanisms regulating vascular smooth muscle function in health and disease. Jeffrey J. Saucerman is a Professor of Biomedical Engineering and Cardiovascular Medicine at the University of Virginia. His research develops experimental and computational methods to discover molecular networks that regulate cardiac remodelling.

The heterocellular heart: identities, interactions, and implications for cardiology

“…Since the 1990s, transgenic animal models with gene overexpression or deletion under the control of cell-selective promoters have been applied to modulate cellular function in vivo [ 43 , 140 , 190 ]. The growing interest in cardiac cell types [ 62 ] is reflected by a substantially growing number of scientific publications. While cardiomyocytes, as the prototypical cell type of the heart, remain the most frequently studied individual cell type, the combined number of published papers per year focused on cardiac immune cells or fibroblasts is comparable (Fig.…”

Adapting to a new environment: postnatal maturation of the human cardiomyocyte

“…Through coordinated activity, the four distinct chambers of the heart work together to deliver oxygenated blood to the body and return deoxygenated blood to the lungs. The cellular composition of the human heart is both heterogeneous and dynamic, and this cellular landscape can change in response to normal development, ageing or disease (Grandi et al., 2023; Litviňuková et al., 2020; Suryawanshi et al., 2020; Tucker et al., 2020). A variety of specialized cell types support heart function, including cardiomyocytes, which compose ∼20–40% of the total number of cells and ∼70–85% of total tissue volume owing to their large size (Bergmann et al., 2015; Litviňuková et al., 2020; Zhou & Pu, 2016).…”

Cell diversity and signalling in the cardiovascular system

“…The white paper in this special issue provides a comprehensive overview of the state of the art in cell diversity research, highlighting key findings and identifying areas where more work is needed (Grandi et al., 2023). The article examines the role of myocytes and non‐myocyte cells in the heart and in the vasculature and how they interact with other cell types to maintain normal heart function.…”

“…The special issue includes a white paper, a review and six original research papers, as well as corresponding perspective articles providing expert commentary and analysis of the latest exciting findings in this important field. The white paper in this special issue provides a comprehensive overview of the state of the art in cell diversity research, highlighting key findings and identifying areas where more work is needed (Grandi et al, 2023). The article examines the role of myocytes and non-myocyte cells in the heart and in the vasculature and how they interact with other cell types to maintain normal heart function.…”