“…Through coordinated activity, the four distinct chambers of the heart work together to deliver oxygenated blood to the body and return deoxygenated blood to the lungs. The cellular composition of the human heart is both heterogeneous and dynamic, and this cellular landscape can change in response to normal development, ageing or disease (Grandi et al., 2023; Litviňuková et al., 2020; Suryawanshi et al., 2020; Tucker et al., 2020). A variety of specialized cell types support heart function, including cardiomyocytes, which compose ∼20–40% of the total number of cells and ∼70–85% of total tissue volume owing to their large size (Bergmann et al., 2015; Litviňuková et al., 2020; Zhou & Pu, 2016).…”