Diversity of Bartonella and Rickettsia spp. in Bats and Their Blood-Feeding Ectoparasites from South Africa and Swaziland

Dietrich, Muriel; Tjale, Mabotse A.; Weyer, Jacqueline; Kearney, Teresa; Seamark, Ernest C.J.; Nel, Louis Hendrik; Monadjem, Ara; Markotter, Wanda

doi:10.1371/journal.pone.0152077

Cited by 50 publications

(32 citation statements)

References 30 publications

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“…The Bartonella occurrence found in the present study (5·28%) was similar to that found in bats (3·38% (13/384)) sampled in Swaziland and South Africa, Africa [40]. Overall there is a relatively higher occurrence of Bartonella in bats sampled in the Old World, such as in Algeria (60% (6/10) by qPCR) [39], Nigeria (51·35% (76/148) by qPCR and 15·54% (23/148) by culture) [30], Kenya (32·02% (106/331) by culture) [4], and Madagascar (44·68% (21/47) by PCR) [33].…”

Section: Discussionsupporting

confidence: 88%

Evidence and molecular characterization ofBartonellaspp. and hemoplasmas in neotropical bats in Brazil

et al. 2017

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The order Chiroptera is considered the second largest group of mammals in the world, hosting important zoonotic virus and bacteria. Bartonella and hemotropic mycoplasmas are bacteria that parasite different mammals' species, including humans, causing different clinical manifestations. The present work aimed investigating the occurrence and assessing the phylogenetic positioning of Bartonella spp. and Mycoplasma spp. in neotropical bats sampled from Brazil. Between December 2015 and April 2016, 325 blood and/or tissues samples were collected from 162 bats comprising 19 different species sampled in five states of Brazil. Out of 322 bat samples collected, while 17 (5·28%) were positive to quantitative PCR for Bartonella spp. based on nuoG gene, 45 samples (13·97%) were positive to cPCR assays for hemoplasmas based on 16S rRNA gene. While seven sequences were obtained for Bartonella (nuoG) (n = 3), gltA (n = 2), rpoB (n = 1), ftsZ (n = 1), five 16S rRNA sequences were obtained for hemoplasmas. In the phylogenetic analysis, the Bartonella sequences clustered with Bartonella genotypes detected in bats sampled in Latin America countries. All five hemoplasmas sequences clustered together as a monophyletic group by Maximum Likelihood and Bayesian Inference analyses. The present work showed the first evidence of circulation of Bartonella spp. and hemoplasmas among bats in Brazil.

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Section: Discussionsupporting

confidence: 88%

Evidence and molecular characterization ofBartonellaspp. and hemoplasmas in neotropical bats in Brazil

et al. 2017

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“…These findings support the phylogenetic studies that have identified shared bartonellae in both bats and their ectoparasites. 14,[32][33][34][35][36][37][38][39] The bat-associated Bartonella strains isolated in Mexico also clustered with those previously described in bats and ectoparasites from other countries in Latin America. However, this is the first identification of Bartonella species in B. plicata, recognizing another bat genus to be infected with bartonellae.…”

Section: Discussionsupporting

confidence: 65%

Bartonella Infection in Hematophagous, Insectivorous, and Phytophagous Bat Populations of Central Mexico and the Yucatan Peninsula

Stuckey

Chomel

Galvez-Romero

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Although emerging nonviral pathogens remain relatively understudied in bat populations, there is an increasing focus on identifying bat-associated bartonellae around the world. Many novel strains have been described from both bats and their arthropod ectoparasites, including, a zoonotic agent of human endocarditis. This cross-sectional study was designed to describe novel strains isolated from bats sampled in Mexico and evaluate factors potentially associated with infection. A total of 238 bats belonging to seven genera were captured in five states of Central Mexico and the Yucatan Peninsula. Animals were screened by bacterial culture from whole blood and/or polymerase chain reaction of DNA extracted from heart tissue or blood. spp. were isolated or detected in 54 (22.7%) bats, consisting of 41 (38%) hematophagous, 10 (16.4%) insectivorous, and three (4.3%) phytophagous individuals. This study also identified as another possible bat reservoir of. Univariate and multivariate logistic regression models suggested that infection was positively associated with blood-feeding diet and ectoparasite burden. Phylogenetic analysis identified a number of genetic variants across hematophagous, phytophagous, and insectivorous bats that are unique from described bat-borne species. However, these strains were closely related to those bartonellae previously identified in bat species from Latin America.

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“…Numerous studies of Bartonella in bat ectoparasites showed positive results [12,13,17,19,29–34]. Ectoparasites may play an important role in the maintenance and transmission of Bartonella among bats [10,13,35].…”

Section: Discussionmentioning

confidence: 99%

Novel Bartonella Species in Insectivorous Bats, Northern China

et al. 2017

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Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2% (27/107) bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.

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Diversity of Bartonella and Rickettsia spp. in Bats and Their Blood-Feeding Ectoparasites from South Africa and Swaziland

Cited by 50 publications

References 30 publications

Evidence and molecular characterization ofBartonellaspp. and hemoplasmas in neotropical bats in Brazil

Evidence and molecular characterization ofBartonellaspp. and hemoplasmas in neotropical bats in Brazil

Bartonella Infection in Hematophagous, Insectivorous, and Phytophagous Bat Populations of Central Mexico and the Yucatan Peninsula

Novel Bartonella Species in Insectivorous Bats, Northern China

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