Diversity of antibiotic resistance genes and encoding ribosomal protection proteins gene in livestock waste polluted environment

Li, Chunyan; Jiang, Cheng; Wu, Zhiyang; Cheng, Binglin; An, Xiaopeng; Wang, Hailan; Sun, Yujing; Huang, Mingyan; Chen, Xi; Wang, Jinming

doi:10.1080/03601234.2018.1438836

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…The figure also shows that tetO and tetW were strongly correlated to each other, which could be explained by its high similarity of amino acid sequences between TetO and TetW, which were categorized into the same group based on the amino acid sequence similarity [8]. The results of this study in terms of the frequency of detection of the RPP tet genes showed that tetO and tetQ, were not as prevalent in the agricultural sites evaluated compared to previous agricultural sites evaluated in previous studies [10,13,36]. The widespread detection of tetW in both arable land and livestock farms was in agreement with other studies [11,13,36], while the infrequent detection of tetS in the agricultural areas of study coincided with the results obtained by Wu et al [10].…”

Section: Tetracycline-resistant Genessupporting

confidence: 47%

“…The results of this study in terms of the frequency of detection of the RPP tet genes showed that tetO and tetQ, were not as prevalent in the agricultural sites evaluated compared to previous agricultural sites evaluated in previous studies [10,13,36]. The widespread detection of tetW in both arable land and livestock farms was in agreement with other studies [11,13,36], while the infrequent detection of tetS in the agricultural areas of study coincided with the results obtained by Wu et al [10]. It is important to note that one animal house in Iksan was found to be negative for the presence of any RPP tet genes.…”

Section: Tetracycline-resistant Genesmentioning

confidence: 55%

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Tetracycline-resistant bacteria and ribosomal protection protein genes in soils from selected agricultural fields and livestock farms

et al. 2021

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Antibiotic resistance in soil environment has eminently been compared and studied between agricultural and pristine soils, and the role of concentrated animal feeding operations has markedly been recognized as one of the major sources of antibiotic resistance. This study described the tetracycline resistance in small-scale farms in pursuit of presenting its possible role and contribution to the persistence of antibiotic resistance in the environment. Results of the study would render additional information on the occurrence of the ribosomal protection protein (RPP) tet genes among the isolated bacteria from the selected agricultural soils. Four tetracycline resistance and RPP genes were determined in two different agricultural soil settings. Both the culture and molecular method were used to determine and measure tetracycline resistance in soils from arable land and animal house. Results revealed a significantly higher number of culturable antibiotic-resistant bacteria in animal houses than arable lands which was suggestive of higher antibiotic resistance in areas where there was direct administration of the antibiotics. However, quantification of the gene copy numbers in the agricultural soils indicated a different result. Higher gene copy number of tetO was determined in one animal house (IAH-3), while the two other tet genes tetQ and tetW were found to be higher in arable lands. Of the total 110 bacterial isolates, tetW gene was frequently detected, while tetO gene was absent in any of the culturable bacterial isolates. Principal component analysis of occurrence and gene copy number of RPP tet genes tetO, tetQ, and tetW also revealed highest abundance of RPP tet genes in the manure and arable soils. Another important highlight of this study was the similarity of the RPP tet genes detected in the isolated bacteria from the agricultural soils to the identified RPP tet genes among pathogenic bacteria. Some of the tetracycline-resistant bacterial isolates were also multidrug resistant as it displayed resistance to tetracycline, erythromycin, and streptomycin using disk diffusion testing.

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Section: Tetracycline-resistant Genessupporting

confidence: 47%

Section: Tetracycline-resistant Genesmentioning

confidence: 55%

Tetracycline-resistant bacteria and ribosomal protection protein genes in soils from selected agricultural fields and livestock farms

et al. 2021

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“…The members of another group of ABC resistance proteins, included in the (putative) drug resistance ATPase families (also called ABC-F proteins), consist of two fused NBDs. Although they were originally reported as putative efflux pumps, possibly interacting with unidentified TMDs, these proteins have since been confirmed to function in ribosomal protection, and their apparent efflux phenotype is likely to be related to displacement of ribosome-targeting antibiotics from the ribosome. − …”

Section: The Movement Of Small Molecules Across Bacterial Cell Envelopesmentioning

confidence: 99%

Physiological Functions of Bacterial “Multidrug” Efflux Pumps

et al. 2021

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Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used to overcome their infections. However, it is increasingly realized that many, probably most, such pumps have physiological roles that are distinct from protection of bacteria against antimicrobials administered by humans. Here we undertake a broad survey of the proteins involved, allied to detailed examples of their evolution, energetics, structures, chemical recognition, and molecular mechanisms, together with the experimental strategies that enable rapid and economical progress in understanding their true physiological roles. Once these roles are established, the knowledge can be harnessed to design more effective drugs, improve existing microbial production of drugs for clinical practice and of feedstocks for commercial exploitation, and even develop more sustainable biological processes that avoid, for example, utilization of petroleum.

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“…143,144 Resistance to an antibiotic develops via several mechanisms including (but not limited to) the activation of antibiotic transporters (efflux pumps), the production of enzymes to inactivate antibiotics, and modification of the target (active) site of the antibiotic. 145 These mechanisms occur via either spontaneous mutations, through the acquisition of antibiotic resistance genes (ARGs) from other bacteria through horizontal gene transfer (HGT), 146 or through infection via bacteriophages. 147 Often the pathogens acquire multi-drug resistance which complicates treatment and leads to poor patient prognosis.…”

Section: Soil Microorganisms and Human Health Current Statusmentioning

confidence: 99%

Soil and Human Health: Current Status and Future Needs

Brevik

Slaughter

Singh

et al. 2020

Air, Soil and Water Research

178

109

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Soil influences human health in a variety of ways, with human health being linked to the health of the soil. Historically, emphasis has been placed on the negative impacts that soils have on human health, including exposures to toxins and pathogenic organisms or the problems created by growing crops in nutrient-deficient soils. However, there are a number of positive ways that soils enhance human health, from food production and nutrient supply to the supply of medications and enhancement of the immune system. It is increasingly recognized that the soil is an ecosystem with a myriad of interconnected parts, each influencing the other, and when all necessary parts are present and functioning (ie, the soil is healthy), human health also benefits. Despite the advances that have been made, there are still many areas that need additional investigation. We do not have a good understanding of how chemical mixtures in the environment influence human health, and chemical mixtures in soil are the rule, not the exception. We also have sparse information on how most chemicals react within the chemically and biologically active soil ecosystem, and what those reactions mean for human health. There is a need to better integrate soil ecology and agronomic crop production with human health, food/nutrition science, and genetics to enhance bacterial and fungal sequencing capabilities, metagenomics, and the subsequent analysis and interpretation. While considerable work has focused on soil microbiology, the macroorganisms have received much less attention regarding links to human health and need considerable attention. Finally, there is a pressing need to effectively communicate soil and human health connections to our broader society, as people cannot act on information they do not have. Multidisciplinary teams of researchers, including scientists, social scientists, and others, will be essential to move all these issues forward.

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Diversity of antibiotic resistance genes and encoding ribosomal protection proteins gene in livestock waste polluted environment

Cited by 10 publications

References 32 publications

Tetracycline-resistant bacteria and ribosomal protection protein genes in soils from selected agricultural fields and livestock farms

Tetracycline-resistant bacteria and ribosomal protection protein genes in soils from selected agricultural fields and livestock farms

Physiological Functions of Bacterial “Multidrug” Efflux Pumps

Soil and Human Health: Current Status and Future Needs

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