Diversity is richness: why data reporting according to sex, age, and ethnicity matters

Lüscher, Thomas F.; Miller, Virginia M.; Merz, C. Noel Bairey; Crea, Filippo

doi:10.1093/eurheartj/ehaa277

Cited by 14 publications

(6 citation statements)

References 51 publications

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“…Regarding other outcomes, we were able to describe that women have more heart failure, pulmonary edema, major bleeding, and stroke, with a marginal increase in cardiogenic shock in STEMI, while these differences blunted with NSTEMI and persisted only for major bleeding and mortality. These factors may be explained from many perspectives, but biologically they may be caused by different responses to drugs that are administered for ACS, hormonal differences, and body composition [2][3][4]. Along with the biological explanations, socioeconomic and demographic factors might contribute to the presence of adverse outcomes [7,8] because of education, transport, or medical services.…”

Section: Discussionmentioning

confidence: 99%

“…In the setting of acute myocardial infarction (AMI), despite advancements in treatment during the last decades, women continue to have worse short-and long-term outcomes than men [2,3]. Several studies have revealed sex-specific differences in AMI regarding clinical presentation, pathophysiological mechanisms, diagnosis, management, and outcomes [4][5][6][7][8][9][10]. Nevertheless, women remain understudied, as they only represent about 20% of the patients enrolled in AMI clinical trials [7].…”

Section: Introductionmentioning

confidence: 99%

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Women with Acute Myocardial Infarction: Clinical Characteristics, Treatment, and In-Hospital Outcomes from a Latin American Country

Arias-Mendoza¹,

González‐Pacheco²,

Álvarez-Sangabriel³

et al. 2023

Global Heart

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Background: Women are underrepresented in acute myocardial infarction (AMI) studies. Furthermore, there is scarce information regarding women with AMI in Latin America.Aims: To describe the presentation, clinical characteristics, risk factor burden, evidencebased care, and in-hospital outcome in a population of women with AMI admitted to a coronary care unit (CCU) in Mexico.Methods: Retrospective cohort study including patients with AMI admitted from January 2006 to December 2021 in a CCU. We identified patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). We described demographic characteristics, clinical variables, treatment, and in-hospital outcomes according to gender. Cox regression analysis was used to identify predictors of mortality. 2 Arias-Mendoza et al.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Women with Acute Myocardial Infarction: Clinical Characteristics, Treatment, and In-Hospital Outcomes from a Latin American Country

Arias-Mendoza¹,

González‐Pacheco²,

Álvarez-Sangabriel³

et al. 2023

Global Heart

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“…Similar findings have been reported elsewhere in Asian populations [ 42 , 43 ]. Of note, this evidence is relevant because Asian populations have historically been under-represented in both observational and randomized studies [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Antithrombotic Therapy and Clinical Outcomes in Patients with Acute Coronary Syndrome and Renal Impairment: Insights from EPICOR and EPICOR Asia

Huo

Werf

Han

et al. 2021

Am J Cardiovasc Drugs

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Background Information is lacking on long-term management of patients with acute coronary syndrome (ACS) and chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m 2 ). Objectives Our objectives were to describe antithrombotic management patterns and outcomes in patients with ACS with varying renal function from the EPICOR (long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients; NCT01171404) and EPICOR Asia (NCT01361386) studies. Methods EPICOR and EPICOR Asia were prospective observational studies of patients who survived hospitalization for ACS and were enrolled at discharge in 28 countries across Europe, Latin America, and Asia. The studies were conducted from 2010 to 2013 and from 2011 to 2014, respectively. This analysis evaluated patient characteristics and oral antithrombotic management patterns and outcomes up to 2 years post-discharge according to admission eGFR: ≥ 90, 60-89, 30-59, or < 30 mL/min/1.73 m 2 . Results Among 22,380 patients with available data, eGFR < 60 mL/min/1.73 m 2 was observed in 16.7%. Patients with poorer renal function were older, were at greater cardiovascular risk, and had more prior cardiovascular disease and bleeding. Patients with CKD underwent fewer cardiovascular interventions and had more in-hospital cardiovascular and bleeding events. Dual antiplatelet therapy was less likely at discharge in patients with eGFR < 30 (82.3%) than in those with ≥ 90 (91.3%) mL/min/1.73 m 2 and declined more sharply during follow-up in patients with low eGFR (p < 0.0001). An adjusted proportional hazards model showed that patients with lower eGFR levels had a higher risk of cardiovascular events and bleeding. Conclusions The presence of CKD in patients with ACS was associated with less aggressive cardiovascular management and an increased risk of cardiovascular events.

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“…Finally, the Journal actively supports equality, diversity and inclusion of sex, gender, age, ethnicity, or geographical diversity, and encourages considering this diversity when reporting and analysing data of studies, registries, and trials (10). The Journal aims to maintain and expand the diversity of its Editorial oard, Reviewer pool and Authors.…”

Section: Pursuit Of Rigour and Transparencymentioning

confidence: 98%

The European Heart Journal: fulfilling the mission

Crea

Badimon

Berry

et al. 2022

European Heart Journal

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In September 2020, the new Editors of the European Heart Journal (EHJ) wrote the following in their inaugural editorial: “The fundamental mission of the Journal remains the reduction of the global burden of cardiovascular disease. We aspire to advance this aim by worldwide teamwork to communicate practice-changing research, inspire clinical cardiologists, and pursue rigour and transparency in the application of science at the service of human health. The Journal will strive to lead the field in its impact, influence, and reach”. After more than one year of experience the Editors hope the cardiological community will agree that they are fulfilling this mission. As stewards of the EHJ, the Editor's primary goal is not solely to achieve a high Impact Factor (which attests to the scientific quality and influence of our publications) but also to elevate the practice of cardiovascular medicine worldwide. Accordingly, various initiatives of the EHJ strive to strengthen further links among Editors, Authors, Reviewers and Readers through a series of coordinated and diverse activities, including webinars, active social media presence, and active participation at congresses worldwide. The Editors are proud to serve one of the most important scientific journals in cardiovascular medicine.

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Diversity is richness: why data reporting according to sex, age, and ethnicity matters

Cited by 14 publications

References 51 publications

Women with Acute Myocardial Infarction: Clinical Characteristics, Treatment, and In-Hospital Outcomes from a Latin American Country

Women with Acute Myocardial Infarction: Clinical Characteristics, Treatment, and In-Hospital Outcomes from a Latin American Country

Long-Term Antithrombotic Therapy and Clinical Outcomes in Patients with Acute Coronary Syndrome and Renal Impairment: Insights from EPICOR and EPICOR Asia

The European Heart Journal: fulfilling the mission

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