Diversity-induced trivialization and resilience of neural dynamics

Abstract

Heterogeneity is omnipresent across all living systems. Diversity enriches the dynamical repertoire of these systems but remains challenging to reconcile with their manifest robustness and dynamical persistence over time, a fundamental feature called resilience. To better understand the mechanism underlying resilience in neural circuits, we considered a nonlinear network model, extracting the relationship between excitability heterogeneity and resilience. To measure resilience, we quantified the number of stationary states of this network, and how they are affected by various control parameters. We analyzed both analytically and numerically gradient and non-gradient systems modeled as non-linear sparse neural networks evolving over long time scales. Our analysis shows that neuronal heterogeneity quenches the number of stationary states while decreasing the susceptibility to bifurcations: a phenomenon known as trivialization. Heterogeneity was found to implement a homeostatic control mechanism enhancing network resilience to changes in network size and connection probability by quenching the system’s dynamic volatility.