Diversity in the Oligomeric Channel Structure of the Multidrug Efflux Pumps in <i>Pseudomonas aeruginosa</i>

Yoshihara, Eisaku; Eda, Shima

doi:10.1111/j.1348-0421.2007.tb03889.x

Cited by 3 publications

(1 citation statement)

References 28 publications

(11 reference statements)

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“…[129] In a cross-linking study performed after OprM/OprJ/OprN reconstitution into liposome, either OprM or OprN formed a trimer; but OprJ unexpectedly was reported to form a tetramer. [130]…”

Section: Drug Efflux Pumps In Bacteria: Structures and Mechanismsmentioning

confidence: 99%

Efflux-Mediated Drug Resistance in Bacteria

Nikaido²

2009

Drugs

893

875

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Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and drug-specific efflux pumps characterized from bacteria of human, animal, plant and environmental origins. These pumps are mostly encoded on the chromosome although they can also be plasmid-encoded. A previous article (Li X-Z and Nikaido H, Drugs, 2004; 64[2]: 159–204) had provided a comprehensive review regarding efflux-mediated drug resistance in bacteria. In the past five years, significant progress has been achieved in further understanding of drug resistance-related efflux transporters and this review focuses on the latest studies in this field since 2003. This has been demonstrated in multiple aspects that include but are not limited to: further molecular and biochemical characterization of the known drug efflux pumps and identification of novel drug efflux pumps; structural elucidation of the transport mechanisms of drug transporters; regulatory mechanisms of drug efflux pumps; determining the role of the drug efflux pumps in other functions such as stress responses, virulence and cell communication; and development of efflux pump inhibitors. Overall, the multifaceted implications of drug efflux transporters warrant novel strategies to combat multidrug resistance in bacteria.

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Section: Drug Efflux Pumps In Bacteria: Structures and Mechanismsmentioning

confidence: 99%

Efflux-Mediated Drug Resistance in Bacteria

Nikaido²

2009

Drugs

893

875

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Efflux: How Bacteria Use Pumps to Control Their Microenvironment

McIntosh

2012

Handbook of Experimental Pharmacology

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Efflux pumps are a potent and clinically important cause of antibiotic resistance. The particular focus of this chapter is on the efflux pump as a target for antimicrobial therapy and the development of new antibacterials to address the efflux problem.Tigecycline is an example of how old antibiotics, in this case tetracyclines, which have become substrates for efflux pumps, can be extensively modified to restore antimicrobial activity and clinical efficacy.

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<em>Pseudomonas aeruginosa</em> bacteremia among liver transplant recipients

Liu¹,

Zhang²,

Wan³

2018

IDR

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Pseudomonas aeruginosa bacteremia remains as a life-threatening complication after liver transplantation (LT) and is intractable because of the high rate of drug resistance to commonly used antibiotics. To better understand the characteristics of this postoperative complication, PubMed and Embase searches as well as reference mining was done for relevant literature from the start of the databases through August 2018. Among LT recipients, the incidence of P. aeruginosa bacteremia ranged from 0.5% to 14.4% and mortality rates were up to 40%. Approximately 35% of all episodes of bloodstream infections (BSIs) were P. aeruginosa bacteremia, of which 47% were multidrug resistant and 63% were extensively drug resistant. Several factors are known to affect the mortality of LT recipients with P. aeruginosa bacteremia, including hypotension, mechanical ventilation, and increasing severity of illness. In LT recipients with P. aeruginosa bacteremia, alteration in DNA gyrase A genes and overexpression of proteins involved in efflux systems, namely the expression of KPC-2-type carbapenemase, NDM-1, and VIM-2-type MBL, contribute to the high resistance of P. aeruginosa to a wide variety of antibiotics. Because of complicated mechanisms of drug resistance, P. aeruginosa causes high morbidity and mortality in bacteremic LT patients. Consequently, early detection and treatment with adequate early targeted coverage for P. aeruginosa BSI are of paramount importance in the early posttransplantation period to obtain a better prognosis for LT patients.

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Diversity in the Oligomeric Channel Structure of the Multidrug Efflux Pumps in Pseudomonas aeruginosa

Cited by 3 publications

References 28 publications

Efflux-Mediated Drug Resistance in Bacteria

Efflux-Mediated Drug Resistance in Bacteria

Efflux: How Bacteria Use Pumps to Control Their Microenvironment

<em>Pseudomonas aeruginosa</em> bacteremia among liver transplant recipients

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