Diversity in Genetic Regulation of Bacterial Fimbriae Assembled by the Chaperone Usher Pathway

Gahlot, Dharmender K.; Taheri, Nayyer; MacIntyre, Sheila

doi:10.3390/ijms24010161

Cited by 11 publications

(6 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 been characterised at an acceptable methodological level. This applies, in particular, to adhesins, toxins, haemolysins, and other factors (Girlich et al, 2020;Gahlot et al, 2022). At the same time, the circumstances (conditions) that affect the intensity of expression of genetic determinants of pathogenicity factors and the possible translocation of the latter within a species remain insufficiently characterised.…”

Section: Discussionmentioning

confidence: 99%

“…4 in foodborne toxicity (Gong et al, 2019). Scientists have carried out many important studies concerning, in particular, the biology of bacteria of the genus Proteus (Esipov & Shapiro, 1998), factors of their pathogenicity ( Armbruster et al, 2012;Broll et al, 2021;Gahlot et al, 2022), in particular, film formation and drug resistance (Akhter et al, 2019), pathogenesis of diseases caused by them in humans and animals ( Schaffer et al, 2016;Prystupa, 2017), and involvement in foodborne toxicity (Gong et al, 2019).…”

Section: Resistance To Physical and Chemical Factors And Drugs Of Bac...mentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2023

Ukrainian journal of veterinary sciences

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Resistance To Physical and Chemical Factors And Drugs Of Bac...mentioning

confidence: 99%

Untitled

2023

Ukrainian journal of veterinary sciences

View full text Add to dashboard Cite

show abstract

“…The surface structures of bacteria of the genus Proteus are represented by flagella and fimbriae. Other structures (spines, curls) are also found (Gahlot et al, 2022).…”

Section: Systematics Morphology Culture and Enzymatic Properties Of P...mentioning

confidence: 98%

Bioecology and pathogenicity of Proteus bacteria: A literature review

Kozlovska

2023

Ukrainian journal of veterinary sciences

View full text Add to dashboard Cite

The role of Proteus bacteria in human and animal pathology has increased significantly in recent years, causing acute intestinal diseases, respiratory, hearing, nervous and urinary systems, as well as contributing to the formation of kidney and bladder stones, postoperative complications, and nosocomial infections. The persistence of some issues, such as their properties and interaction with the microbiocenosis, remains a subject of debate even after a long study of Proteus bacteria. The research aims to identify promising areas for further study of Proteus microorganisms. The information from scientific primary sources on the results of studying microorganisms of the genus Proteus was used for the analysis. The study results of Proteus bacteria performed by domestic and foreign scientists on the knowledge of their bioecology and potential pathogenicity factors (adhesins, toxins, haemolysins, etc.), characterisation of the positive role of proteins as biodegraders of harmful substances – bioremediators of proper environmental ecology; substantiation of promising areas for further research of bacteria of the genus Proteus, which will contribute to the development of an effective methodology for the prevention and treatment of diseases caused by them, the development of rational technologies for the use of their strains – bioremediators of the environment contaminated with harmful substances – are presented in the study. Further study of the genomic properties of Proteus bacteria will contribute to a clear understanding of the mechanisms of their potential pathogenicity factors and help to identify and understand the essence of the processes that contribute to the acquisition of new pathogenicity factors and drug resistance. The study of their interaction with representatives of the intestinal microbiocenosis of humans and animals will help to establish the nature of such interaction, determine the feasibility, prospects and rational directions in the creation of effective probiotics

show abstract

“…Flagella and pili are the major fiber proteins present in a wide range of bacteria. These proteins are composed of thousands of subunits, and their assembly is governed by complex, highly regulated genetic and biochemical processes that ensure their structural integrity and functions (9)(10)(11). In addition, many gramnegative bacteria have autotransporter adhesins, which are secreted by the type V secretion system and consist of a passenger domain that is displayed on the outer membrane (OM) and a transmembrane domain that functions as a translocator (12).…”

Section: Introductionmentioning

confidence: 99%

A new target of multiple lysine methylation in bacteria

Inoue,

Yoshimoto,

Hori

2024

Preprint

View full text Add to dashboard Cite

The methylation of ε-amino groups in protein lysine residues is known to be an important posttranslational modification in eukaryotes. This modification plays a pivotal role in the regulation of diverse biological processes, including epigenetics, transcriptional control, and cellular signaling. Although less studied in prokaryotes, recent research has begun to reveal the potential role of methylation in modulating bacterial immune evasion and adherence to host cells. In this study, we analyzed the cell surface proteins of the toluene-degrading bacterium Acinetobacter sp. Tol 5 by label-free liquid chromatography‒mass spectrometry (LC‒MS) and found that the lysine residues of its trimeric autotransporter adhesin (TAA), AtaA, are methylated. Over 130 lysine residues of AtaA, consisting of 3,630 amino acids and containing 232 lysine residues, were methylated. We identified the outer membrane protein lysine methyltransferase (OM PKMT) of Tol 5, KmtA, which specifically methylates the lysine residues of AtaA. In the KmtA-deficient mutant, most lysine methylations on AtaA were absent, indicating that KmtA is responsible for the methylation of multiple lysine residues throughout AtaA. Bioinformatic analysis revealed that the OM PKMT genes were widely distributed among gram-negative bacteria, including pathogens with TAAs that promote infectivity, such as Burkholderia mallei and Haemophilus influenzae. Although KmtA has sequence similarities to the OM PKMTs of Rickettsia involved in infectivity, KmtA-like PKMTs formed a distinct cluster from those of the Rickettsia type according to the clustering analysis, suggesting that they are new types of PKMTs. Furthermore, the deletion of Tol 5 KmtA led to an increase in AtaA on the cell surface and enhanced bacterial adhesion, resulting in slower growth.

show abstract

Diversity in Genetic Regulation of Bacterial Fimbriae Assembled by the Chaperone Usher Pathway

Cited by 11 publications

References 116 publications

Untitled

Untitled

Bioecology and pathogenicity of Proteus bacteria: A literature review

A new target of multiple lysine methylation in bacteria

Contact Info

Product

Resources

About