Diversity in Functional Properties and Primary Structure of Neuronal Nicotinic Receptor Channels

Dévay, Piroska; Brussaard, Arjen B.; Listerud, Mark; Moss, Brenda L.; Qu, Xueping; Role, L. W.

doi:10.1159/000173811

Cited by 4 publications

(6 citation statements)

References 5 publications

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“…Since α5-specific monoclonal antibody 35 (mAb35) blocks catecholamine release from bovine adrenal gland, the presence of this subunit in nAChRs principally responsible for nAChR-mediated sympathetic outflow is indicated . There is evidence to suggest that some synaptic nAChRs in sympathetic neurons may contain the α7 subunit. , …”

Section: Synaptic Ganglionic Nachr Subtype(s): Nachrs Mediating Peri...mentioning

confidence: 99%

Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

1997

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Section: Synaptic Ganglionic Nachr Subtype(s): Nachrs Mediating Peri...mentioning

confidence: 99%

Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

1997

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“…Thus, ligand-gated ion channels can be thought of as (cations). In the biological context, these receptors are prototypical allosteric proteins, such that the regulatory, Nicotinic receptors have been the subject of a number of excellent reviews, addressing such issues as: receptor structure [18,23-27]; functional significance and implications of subtype diversity [5,8,[28][29][30]. Receptor kinetics and allosterism are also explored in a number of manuscripts [26, [34][35][36].…”

Section: Section I-backgroundmentioning

confidence: 99%

Exploring the Nature of Molecular Recognition in Nicotinic Acetylcholine Receptors

Schmitt

2000

CMC

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Nicotinic acetylcholine receptors (nAChRs) are the subject of ever increasing interest because of their presumed involvement in the etiology of numerous clinical disorders. Unfortunately, the absence of atomic-level structural data, as well as the pharmacological complexity of these receptors leaves many fundamental questions unanswered. An understanding of how ligands interact with the receptor and, in-turn, how these interactions lead to pharmacological effect is vital in the advancement of nAChR-based therapeutics. We will first explore physico-chemical themes that are evidenced to be of particular importance in nAChR molecular recognition; these are- pi-cation interaction, conformational entropy and stereochemistry. The second objective of this review is an interpretive encapsulation of the extensive and disparate body of structure-activity data that now exists for nAChRs. Finally, this review will advocate a re-investigation of distance geometry based methods as well as the need for additional approaches in nicotinic receptor pharmacophore generation.

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“…During postnatal development of rat SCG, a3 and h4 mRNA levels increase relatively dramatically, but h2 do not [5]. These two periods of development are important for synapse formation and maturation [37][38][39]. Postganglionic nerve transection of the adult rat SCG leads to a decrease in the transcript levels of a3 and h4 subunits in SCG neurons, but not of h2 transcripts [40].…”

Section: Introductionmentioning

confidence: 96%