Diversity in clinical trials: an opportunity and imperative for community engagement

Gray, Darrell M.; Nolan, Timiya S.; Gregory, John R.; Joseph, Joshua J.

doi:10.1016/s2468-1253(21)00228-4

Cited by 51 publications

(42 citation statements)

References 4 publications

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“…Successful approaches to improve attainment of ICH may need to focus on multilevel, community‐engaged interventions that include SES and factors beyond SES to improve attainment of ICH status in Black men. 64 Potential avenues for future investigation include examining the impact of other SDOH, patient–physician engagement, and discrimination in attainment of ICH in Black men.…”

Section: Discussionmentioning

confidence: 99%

Association of Socioeconomic Status With Ideal Cardiovascular Health in Black Men

Azap

Nolan

Gray

et al. 2021

JAHA

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Background Black men are burdened by high cardiovascular risk and the highest all‐cause mortality rate in the United States. Socioeconomic status (SES) is associated with improved cardiovascular risk factors in majority populations, but there is a paucity of data in Black men. Methods and Results We examined the association of SES measures including educational attainment, annual income, employment status, and health insurance status with an ideal cardiovascular health (ICH) score, which included blood pressure, glucose, cholesterol, body mass index, physical activity, and smoking in African American Male Wellness Walks. Six metrics of ICH were categorized into a 3‐tiered ICH score 0 to 2, 3 to 4, and 5 to 6. Multinomial logistic regression modeling was performed to examine the association of SES measures with ICH scores adjusted for age. Among 1444 men, 7% attained 5 to 6 ICH metrics. Annual income <$20 000 was associated with a 56% lower odds of attaining 3 to 4 versus 0 to 2 ICH components compared with ≥$75 000 ( P =0.016). Medicare and no insurance were associated with a 39% and 35% lower odds of 3 to 4 versus 0 to 2 ICH components, respectively, compared with private insurance (all P <0.05). Education and employment status were not associated with higher attainment of ICH in Black men. Conclusions Among community‐dwelling Black men, higher attainment of measures of SES showed mixed associations with greater attainment of ICH. The lack of association of higher levels of educational attainment and employment status with ICH suggests that in order to address the long–standing health inequities that affect Black men, strategies to increase attainment of cardiovascular health may need to address additional components beyond SES.

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Section: Discussionmentioning

confidence: 99%

Association of Socioeconomic Status With Ideal Cardiovascular Health in Black Men

Azap

Nolan

Gray

et al. 2021

JAHA

Self Cite

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“…We found that women represented 90%, 95%, and more than 99% of total samples in studies on binge eating disorder, anorexia nervosa, and bulimia nervosa, respectively. As the under-representation of diverse groups in outcome-related ED trials may have inadvertently facilitated the development of more effective treatments for cis-gender women, enhancing diversity representation in clinical ED trials is vital for ensuring optimal health care delivery and identifying areas in need of further improvement (76). First examples of gender-based comparisons suggest equality among treatment outcomes (77)(78)(79)(80)(81), but there is still a dearth of systematic investigations concerning gender and other diversity-related differences in outcome-related research.…”

Section: Diversity In Treatment Settingsmentioning

confidence: 99%

A Plea for Diversity in Eating Disorders Research

2022

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Eating disorders (EDs) are often stereotyped as affecting the SWAG, that is, as affecting mostly skinny, White, affluent girls. Over the last decade, however, significant progress has been made toward increasing diversity in ED research. There is consensus that EDs affect individuals of all genders, ages, sexual orientations, ethnic, and socio-economic backgrounds, with recent studies exploring social determinants of ED etiology, ED presentation, and developing diversity-affirming ED assessments. This article provides a brief summary of current developments related to diversity as a research theme, and proposes different perspectives toward further improving diversity in ED research. Specifically, we argue for exploring the role of diversity in ED treatment settings and outcomes, for pursuing diversity-oriented research pro-actively rather than as a reaction to issues of under-representation, and for integrating diversity across different areas of medical education and trainings in psychotherapy. Limitations with respect to the paucity of research, and the link between diversity as a research theme and ED-related workforce diversity are discussed.

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“…This health inequity has been highlighted recently and is an important concern because people of different races and ethnicities may react differently to certain medical products. 42 , 43 …”

Section: Discussionmentioning

confidence: 99%

International Country-Level Trends, Factors, and Disparities in Compassionate Use Access to Unlicensed Products for Patients With Serious Medical Conditions

et al. 2022

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Diversity in clinical trials: an opportunity and imperative for community engagement

Cited by 51 publications

References 4 publications

Association of Socioeconomic Status With Ideal Cardiovascular Health in Black Men

Association of Socioeconomic Status With Ideal Cardiovascular Health in Black Men

A Plea for Diversity in Eating Disorders Research

International Country-Level Trends, Factors, and Disparities in Compassionate Use Access to Unlicensed Products for Patients With Serious Medical Conditions

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