Diversity and abundance of the abnormal chromosome 10 meiotic drive complex in Zea mays

Kanizay, Lisa B.; Pyhäjärvi, Tanja; Lowry, Elizabeth G.; Hufford, Matthew B.; Peterson, Daniel G.; Ross‐Ibarra, Jeffrey; Dawe, R. Kelly

doi:10.1038/hdy.2013.2

Cited by 24 publications

(36 citation statements)

References 86 publications

(156 reference statements)

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“…; Kanizay et al. ). This implies either substantial homozygous costs (greater than those in Mimulus ) or heterozygous costs (Buckler et al.…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, the neo-centromeric Ab10 chromosomal variant in maize, which drives at Meiosis II to gain up to a 75:25 transmission advantage (Dawe and Cande 1996;Birchler et al 2003;Dawe and Hiatt 2004), shows no evidence of intrinsic seedset or pollen viability costs in heterozygotes. Ab10 is widespread across wild teosinte (Zea mays) subspecies, but occurs at low (0-20%) frequency per population (Buckler et al 1999;Kanizay et al 2013). This implies either substantial homozygous costs (greater than those in Mimulus) or heterozygous costs (Buckler et al 1999).…”

Section: Comparison With Other Drive Systemsmentioning

confidence: 99%

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Centromere-associated meiotic drive and female fitness variation inMimulus

2015

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Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained as balanced polymorphisms by pleiotropic or linked fitness costs. A centromere-associated driver (D) with a ~58:42 female-specific transmission advantage occurs at intermediate frequency (32–40%) in the Iron Mountain population of the yellow monkeyflower, Mimulus guttatus. Previously determined male fertility costs are sufficient to prevent the fixation of D, but predict a higher equilibrium frequency. To better understand the dynamics and effects of D, we developed a new population genetic model and measured genotype-specific lifetime female fitness in the wild. In three of four years, and across all years, D imposed significant recessive seedset costs, most likely due to hitchhiking by deleterious mutations. With both male and female costs as measured, and 58:42 drive, our model predicts an equilibrium frequency of D (38%) very close to the observed value. Thus, D represents a rare selfish genetic element whose local population genetic dynamics have been fully parameterized, and the observation of equilibrium sets the stage for investigations of coevolution with suppressors.

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“…; Kanizay et al. ). This implies either substantial homozygous costs (greater than those in Mimulus ) or heterozygous costs (Buckler et al.…”

Section: Discussionmentioning

confidence: 98%

Section: Comparison With Other Drive Systemsmentioning

confidence: 99%

Centromere-associated meiotic drive and female fitness variation inMimulus

2015

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“…The heterochromatic knobs discovered by McClintock (1929) are composed primarily of repeated units of 180 and 350 bp (called knob180 and TR-1, respectively) that can occur in arrays of diverse sizes and positions throughout the genome (Ghaffari et al, 2013;Kanizay et al, 2013). Maize centromeres contain a 156-bp repeating unit called CentC (Wolfgruber et al, 2009).…”

Section: Heterochromatic Structure and Rddm Depletion Of Knobs And Cementioning

confidence: 99%

“…The abundance of the transposons and tandem repeats that make up this repetitive DNA is highly variable between species and even between populations within a single species, as illustrated by studies in maize (Zea mays) (Tenaillon et al, 2011;Kanizay et al, 2013). Repetitive regions of the genomes were identified early on by their dense staining, both by light and electron microscopy.…”

Section: Introductionmentioning

confidence: 99%

Accessible DNA and Relative Depletion of H3K9me2 at Maize Loci Undergoing RNA-Directed DNA Methylation

et al. 2014

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RNA-directed DNA methylation (RdDM) in plants is a well-characterized example of RNA interference-related transcriptional gene silencing. To determine the relationships between RdDM and heterochromatin in the repeat-rich maize (Zea mays) genome, we performed whole-genome analyses of several heterochromatic features: dimethylation of lysine 9 and lysine 27 (H3K9me2 and H3K27me2), chromatin accessibility, DNA methylation, and small RNAs; we also analyzed two mutants that affect these processes, mediator of paramutation1 and zea methyltransferase2. The data revealed that the majority of the genome exists in a heterochromatic state defined by inaccessible chromatin that is marked by H3K9me2 and H3K27me2 but that lacks RdDM. The minority of the genome marked by RdDM was predominantly near genes, and its overall chromatin structure appeared more similar to euchromatin than to heterochromatin. These and other data indicate that the densely staining chromatin defined as heterochromatin differs fundamentally from RdDM-targeted chromatin. We propose that small interfering RNAs perform a specialized role in repressing transposons in accessible chromatin environments and that the bulk of heterochromatin is incompatible with small RNA production.

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“…Meiotic drive elements are found across the eukaryote tree of life (Burt and Trivers 2008; Bravo Núñez et al . 2018) and classic examples include SD in fruit flies (Larracuente and Presgraves 2012), the t- complex in mice (Lyon 2003; Sugimoto 2014), and Ab10 in Zea mays (Rhoades 1952; Kanizay et al 2013). In the fungal kingdom, the known meiotic drive elements achieve biased transmission through spore killing (Raju 1994) and a handful of spore killer systems have been studied in detail.…”

Section: Introductionmentioning

confidence: 99%

Identification of a genetic element required for spore killing in Neurospora

Rhoades

Harvey

Samarajeewa

et al. 2018

Preprint

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34Meiotic drive elements like Spore killer-2 (Sk-2) in Neurospora are transmitted through sexual 35 reproduction to the next generation in a biased manner. Sk-2 achieves this biased transmission 36 through spore killing. Here, we identify rfk-1 as a gene required for the spore killing mechanism. 37The rfk-1 gene is associated with a 1,481 bp DNA interval (called AH36) near the right border of 38 the 30 cM Sk-2 element, and its deletion eliminates the ability of Sk-2 to kill spores. The rfk-1 39 gene also appears to be sufficient for spore killing because its insertion into a non-Sk-2 isolate 40 disrupts sexual reproduction after the initiation of meiosis. Although the complete rfk-1 41 transcript has yet to be defined, our data indicate that rfk-1 encodes a protein of at least 39 amino 42 acids and that rfk-1 has evolved from a partial duplication of gene ncu07086. We also present 43 evidence that rfk-1's location near the right border of Sk-2 is critical for the success of spore 44 killing. Increasing the distance of rfk-1 from the right border of Sk-2 causes it to be inactivated 45 by a genome defense process called meiotic silencing by unpaired DNA (MSUD), adding to 46 accumulating evidence that MSUD exists, at least in part, to protect genomes from meiotic drive. 47 48 49 50In eukaryotic organisms, genetic loci are typically transmitted through sexual reproduction to the 51 next generation in a Mendelian manner. However, some loci possess the ability to improve their 52 own transmission rate through meiosis at the expense of a competing locus. These "selfish" loci 53 are often referred to as meiotic drive elements (Zimmering et al. 1970). The genomic conflict 54 caused by meiotic drive elements may impact processes ranging from gametogenesis to 55 speciation (Lindholm et al. 2016). Meiotic drive elements are found across the eukaryote tree of 56 life (Burt and Trivers 2008; Bravo Núñez et al. 2018) and classic examples include SD in fruit 57 flies (Larracuente and Presgraves 2012), the t-complex in mice (Lyon 2003; Sugimoto 2014), 58and Ab10 in Zea mays (Rhoades 1952; Kanizay et al. 2013). In the fungal kingdom, the known 59 meiotic drive elements achieve biased transmission through spore killing (Raju 1994) and a 60 handful of spore killer systems have been studied in detail. While the prion-based spore killing 61 mechanism of het-s in Podospora anserina is the best characterized (Dalstra et al. 2003; Saupe 62 2011), the mechanisms by which other fungal meiotic drive elements kill spores are mostly 63 unknown (e.g., see Grognet et al. 2014; Hu et al. 2017; Nuckolls et al. 2017). 65Two fungal meiotic drive elements have been identified in the fungus Neurospora 66 intermedia (Turner and Perkins, 1979). This species is closely related to the genetic model 67 Neurospora crassa (Davis 2000), and the mating processes in both fungi are essentially identical. 68Mating begins with fertilization of an immature fruiting body called a protoperithecium by a 69 mating partner of the opposite mating type. After ferti...

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Diversity and abundance of the abnormal chromosome 10 meiotic drive complex in Zea mays

Cited by 24 publications

References 86 publications

Centromere-associated meiotic drive and female fitness variation inMimulus

Centromere-associated meiotic drive and female fitness variation inMimulus

Accessible DNA and Relative Depletion of H3K9me2 at Maize Loci Undergoing RNA-Directed DNA Methylation

Identification of a genetic element required for spore killing in Neurospora

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