Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria

Zheng, Shaokuan; Sonomoto, Kenji

doi:10.1007/s00253-018-8917-5

Cited by 34 publications

(36 citation statements)

References 116 publications

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“…Toxin Delivery: Secretion, Suicide and Stabbing To employ a chemical attack, a cell must first export its toxins. Small toxins may diffuse out of the producing cell, often via protein pores, or are released by active transport across the cell envelope [67,68]. Other toxins are released in membrane vesicles that bleb from the surface of the producing cell and can deliver many molecules to a target cell in one go [44,69].…”

Section: Chemical Warfarementioning

confidence: 99%

The Evolution and Ecology of Bacterial Warfare

2019

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Bacteria have evolved a wide range of mechanisms to harm and kill their competitors, including chemical, mechanical and biological weapons. Here we review the incredible diversity of bacterial weapon systems, which comprise antibiotics, toxic proteins, mechanical weapons that stab and pierce, viruses, and more. The evolution of bacterial weapons is shaped by many factors, including cell density and nutrient abundance, and how strains are arranged in space. Bacteria also employ a diverse range of combat behaviours, including pre-emptive attacks, suicidal attacks, and reciprocation (tit-for-tat). However, why bacteria carry so many weapons, and why they are so often used, remains poorly understood. By comparison with animals, we argue that the way that bacteria live -often in dense and genetically diverse communities -is likely to be key to their aggression as it encourages them to dig in and fight alongside their clonemates. The intensity of bacterial aggression is such that it can strongly affect communities, via complex coevolutionary and ecoevolutionary dynamics, which influence species over space and time. Bacterial warfare is a fascinating topic for ecology and evolution, as well as one of increasing relevance. Understanding how bacteria win wars is important for the goal of manipulating the human microbiome and other important microbial systems. StrategyRule(s) defining the decisions of an actor in response to prevailing conditions (for example, fight back if attacked). TacticsBehaviours displayed in a given contest (the realised output of a strategy). ToxinSubstance that disrupts cell physiology. WarfareConflict involving weapons between two or more groups. WeaponCompetitive phenotype that damages and/or disrupts the physiology of recipients, and that evolved, at least in part, for that purpose (for example, bacteriocin production).

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Section: Chemical Warfarementioning

confidence: 99%

The Evolution and Ecology of Bacterial Warfare

2019

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“…It was highly efficient in killing S. aureus (Gram-positive bacteria) and the Mycobacterium tuberculosis H37Rv strain when compared to laterosporulin (Baindara et al, 2017). Interestingly, Class II bacteriocins are easily manipulated by genetic engineering techniques because they do not have large post-translational modifications and it is possible to obtain variants according to the technological requirements and needs (Zheng and Sonomoto, 2018;Kumariya et al, 2019). Therefore, this technique could be useful to develop new antimicrobial peptides to be used as an alternative to common antibiotics.…”

Section: Bacteriocins As Alternative Antimicrobial Agentsmentioning

confidence: 99%

Bacteriocins: An Overview of Antimicrobial, Toxicity, and Biosafety Assessment by in vivo Models

et al. 2021

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The world is facing a significant increase in infections caused by drug-resistant infectious agents. In response, various strategies have been recently explored to treat them, including the development of bacteriocins. Bacteriocins are a group of antimicrobial peptides produced by bacteria, capable of controlling clinically relevant susceptible and drug-resistant bacteria. Bacteriocins have been studied to be able to modify and improve their physicochemical properties, pharmacological effects, and biosafety. This manuscript focuses on the research being developed on the biosafety of bacteriocins, which is a topic that has not been addressed extensively in previous reviews. This work discusses the studies that have tested the effect of bacteriocins against pathogens and assess their toxicity using in vivo models, including murine and other alternative animal models. Thus, this work concludes the urgency to increase and advance the in vivo models that both assess the efficacy of bacteriocins as antimicrobial agents and evaluate possible toxicity and side effects, which are key factors to determine their success as potential therapeutic agents in the fight against infections caused by multidrug-resistant microorganisms.

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“…Apart from the ABC family, which operates through ATP hydrolysis, the other efflux families obtain their energy from the proton motive force. In particular, the RND family complex is in a wide range of Gram-negative and Gram-positive bacteria, consisting of a hydrophobic channel that can extrude multiple antimicrobial agents [ 87 , 88 ]. One way to counteract the antimicrobial-resistance via efflux pumps is through the incorporation of Efflux Pump Inhibitors (EPIs), however physiological cytotoxicity has been linked with EPIs when used in high dosages.…”

Section: Synergy and Resistance To Mapsmentioning

confidence: 99%

Synergies with and Resistance to Membrane-Active Peptides

et al. 2020

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Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synergy. This discussion takes place considering resistance, and/or synergy in the extracellular space, at the membrane, and during interaction, and/or removal. Overall, this review shows that researchers require improved definitions of resistance and a more thorough understanding of MAP-resistance mechanisms. The solution to combating resistance may ultimately come from an understanding of how to harness the power of synergistic drug combinations.

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Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria

Cited by 34 publications

References 116 publications

The Evolution and Ecology of Bacterial Warfare

The Evolution and Ecology of Bacterial Warfare

Bacteriocins: An Overview of Antimicrobial, Toxicity, and Biosafety Assessment by in vivo Models

Synergies with and Resistance to Membrane-Active Peptides

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