Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Enzymatic synthesis of amlodipine amides and evaluation of their anti-Trypanosoma cruziactivity

“…14 The dihydropyridine moiety is also a privileged scaffold with several biological activities reported, such as antimicrobial, anticancer, anticonvulsant, anti-coagulant, antioxidant, antiulcer and neuroprotective activities. 15,16 Amlodipine (3) is considered a frontline agent in hypertension management due to its potent and long-acting effect. 17 Regarding the antiparasitic activity, amlodipine demonstrated promising in vitro and in vivo activity against a series of human pathogenic parasites, such as Trypanosoma cruzi, [18][19][20] Leishmania spp., [21][22][23] Plasmodium sp., 24,25 Acanthamoeba castellanii and Naegleria fowleri.…”