Diversified Polyketides and Nitrogenous Compounds from the Mangrove Endophytic Fungus <i>Penicillium steckii</i><scp>SCSIO</scp> 41025

Chen, Chunmei; Chen, Wei-Hao; Tao, Huaming; Yang, Bin; Zhou, Xuefeng; Luo, Xiaowei; Liu, Yonghong

doi:10.1002/cjoc.202100226

Cited by 14 publications

(20 citation statements)

References 40 publications

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“…These results indicated that compound 13 attenuated the acute lung injury (ALI) caused by LPS-induced inflammation. Furthermore, “cytokine storm” is well characterized in ALI ( Chen et al, 2021c ). The cytokine detection in the bronchoalveolar lavage fluid (BALF) revealed that the levels of pro-inflammatory factors, such as IL-6, TNF- α , and MCP-1, in compound 13 administrated group were generally lower ( Figure 6C ) than those of the model group.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026

Ren

Chen

et al. 2022

Front. Microbiol.

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Three new chlorinated compounds, including two propenylphenol derivatives, chlorophenol A and B (1 and 2), and one benzofuran derivative, chlorophenol C (3), together with 16 known compounds, were isolated from the mangrove endophytic fungus Amorosia sp. SCSIO 41026. 7-Chloro-3,4-dihydro-6,8-dihydroxy-3-methylisocoumarine (4) and 2,4-dichloro-3-hydroxy-5-methoxy-toluene (5) were obtained as new natural products. Their structures were elucidated by physicochemical properties and extensive spectroscopic analysis. Compounds 1, 4, 7, 9, 13, 15, 16, and 19 possessed inhibitory effects against the excessive production of nitric oxide (NO) and pro-inflammatory cytokines in lipopolysaccharide (LPS)-challenged RAW264.7 macrophages without obvious cytotoxicity. Moreover, 5-chloro-6-hydroxymellein (13) further alleviated the pathological lung injury of LPS-administrated mice and protected RAW264.7 macrophages against LPS-induced inflammation through PI3K/AKT pathway in vivo. Our research laid the foundation for the application of compound 13 as a potential anti-inflammatory candidate.

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Section: Resultsmentioning

confidence: 99%

Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026

Ren

Chen

et al. 2022

Front. Microbiol.

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“…In conclusion, eight new polyketide derivatives ( 1 – 8 ) and two related known analogues ( 9 and 10 ) were identified from the endozoic fungus P. steckii AS-324, which was obtained from the fresh tissues of deep-sea Acanthogorgiidae sp. coral collected from Magellan seamount in the Western Pacific Ocean at a depth of 1458 m. Compounds 1 – 3 , with an acrylic acid side chain at C-4, have been rarely observed [ 28 ], and the double bond between C-12 and C-13 in compound 4 is a new observation. Antimicrobial activities of compounds 1 – 10 were tested, and compound 8 showed potent activity against E. coli with an MIC value of 8 μg/mL while compound 10 exhibited inhibitory activity against E. tarda with an MIC value of 16 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount

Wang

et al. 2022

IJMS

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Four unusual steckwaic acids E–H (1–4), possessing a rarely described acrylic acid unit at C-4 (1–3) or a double bond between C-12 and C-13 (4) are reported for the first time, along with four new analogues (5–8) and two known congeners (9 and 10). They were purified from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral Acanthogorgiidae sp., which was collected from the Magellan Seamount at a depth of 1458 m. Their structures were determined by the interpretation of NMR and mass spectroscopic data. The relative and absolute configurations were determined by NOESY correlations, X-ray crystallographic analysis, and ECD calculations. All compounds were tested for their antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi.

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“…Antibacterial effects against a panel of marine biofilm-forming bacterial strains, including methicillin-resistant Staphylococcus aureus , Pseudomonas aeruginosa , Vibrio parahemolyticus , V. alginolyticus , V. tubiashii , Microbulbifer variabilis , Marinobacterium jannaschii , V. pelagius , V. rotiferianus , and Alteromonas macleodii , were tested using our previously reported method [ 30 ]. Chloramphenicol, nalidixic acid, streptomycin, and/or ampicillin were used as positive controls.…”

Section: Methodsmentioning

confidence: 99%

Anti-Osteoclastogenic and Antibacterial Effects of Chlorinated Polyketides from the Beibu Gulf Coral-Derived Fungus Aspergillus unguis GXIMD 02505

Zhang

Huang

et al. 2022

Marine Drugs

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One new depsidone derivative, aspergillusidone H (3), along with seven known biosynthetically related chlorinated polyketides, were obtained from the Beibu Gulf coral-derived fungus Aspergillus unguis GXIMD 02505. Their structures were determined by comprehensive physicochemical and spectroscopic data interpretation. Notably, the X-ray crystal structure of 2 and the previously unknown absolute configuration of 8, assigned by ECD calculations, are described here for the first time. Compounds 1–5, 7 and 8 exhibited inhibition of lipopolysaccharide (LPS)-induced NF-κB in RAW 264.7 macrophages at 20 μM. In addition, the two potent inhibitors (2 and 7) dose-dependently suppressed RANKL-induced osteoclast differentiation without any evidence of cytotoxicity in bone marrow macrophages cells (BMMs). This is the first report of osteoclastogenesis inhibitory activity for the metabolites of these kinds. Besides, compounds 1, 2, 4, and 6–8 showed inhibitory activity against marine biofilm-forming bacteria, methicillin-resistant Staphylococcus aureus, Microbulbifer variabilis, Marinobacterium jannaschii, and Vibrio pelagius, with their MIC values ranging from 2 to 64 μg/mL. These findings provide a basis for further development of chlorinated polyketides as potential inhibitors of osteoclast differentiation and/or for use as anti-fouling agents.

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Diversified Polyketides and Nitrogenous Compounds from the Mangrove Endophytic Fungus Penicillium steckiiSCSIO 41025

Cited by 14 publications

References 40 publications

Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026

Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026

Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount

Anti-Osteoclastogenic and Antibacterial Effects of Chlorinated Polyketides from the Beibu Gulf Coral-Derived Fungus Aspergillus unguis GXIMD 02505

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