Diversification post-traductionnelle de la spécificité des immunoglobulines

Planchais, Cyril; Gupta, Nimesh; Kaveri, Srini V.; Lacroix‐Desmazes, Sébastien; Dimitrov, Jordan D.

doi:10.1051/medsci/20132911002

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Heme-induced Reactivity1

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2015

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“…The transient interaction of heme with a fraction of circulating Abs that could use the properties of the cofactor to extend their antigen binding repertoire may represent yet another regulatory function of heme. Thus, cofactor-binding Abs present in the circulation might be regarded as a source of antigen binding specificities in immune repertoires (60). The novel antigen specificities of these Abs would be recruited only as result of certain pathological conditions.…”

Section: Heme-induced Reactivitymentioning

confidence: 99%

Prevalence and Gene Characteristics of Antibodies with Cofactor-induced HIV-1 Specificity

Lecerf

Scheel

Pashov

et al. 2015

Journal of Biological Chemistry

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Background: Normal immune repertoires have a fraction of cofactor-binding antibodies. Results: Heme exposure results in acquisition of reactivity to gp120 HIV-1 in 24% of antibodies in a seronegative immune repertoire; these antibodies have less mutated variable regions. Conclusion: Human immune repertoires contain high frequency of antibodies with cofactor-induced antigen specificities. Significance: This work enhances understanding of molecular features of heme-sensitive Abs and their contribution to diversification of the immune repertoires.

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Section: Heme-induced Reactivitymentioning

confidence: 99%