Diverse Therapeutic Applications of Onion

Borah, Preetismita; Banik, Bimal K.

doi:10.33696/pharmacol.1.003

Cited by 1 publication

(3 citation statements)

References 11 publications

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“…Subsequently, the known ligand dataset was created Antioxidant activity [124,126] Advances in Pharmacological and Pharmaceutical Sciences Same as no. 17 Antibacterial and antimicrobial activities [172,[183][184][185] Advances in Pharmacological and Pharmaceutical Sciences Antioxidant activity [172,191] 57 Trisulfde dipropyl (PubChem ID: 22383)…”

Section: Preparation Of Known Ligand Datasetmentioning

confidence: 99%

“…Antimicrobial and anticarcinogenic activities [172,193,194] 59 Diisopropyl disulfde (PubChem ID: 77932)…”

Section: Preparation Of Known Ligand Datasetmentioning

confidence: 99%

“…Antioxidative activity [172,195] 60 Methyl propenyl disulfde (PubChem ID: 5366552) Antioxidant, antibacterial, and antimicrobial activities [172,196,197] 61 6-Methyl-4,5-dithia-1-heptene (PubChem ID: 525503) - [172] 10 Advances in Pharmacological and Pharmaceutical Sciences Advances in Pharmacological and Pharmaceutical Sciences using MOE's default parameters following minimizing energy by MOPAC in MOE (0.1 kcal/mol).…”

Section: Preparation Of Known Ligand Datasetmentioning

confidence: 99%

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Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies

Ahmad,

Lesa,

Ujiantari

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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Human cognition fundamentally depends on memory. Alzheimer’s disease exhibits a strong correlation with a decline in this factor. Phosphodiesterase-4 B (PDE4B) plays a crucial role in neurodegenerative disorders, and its inhibition is one of the promising approaches for memory enhancement. This study aimed to identify secondary metabolites in white cabbage, coffee, and red onion extracts and identify their molecular interaction with PDE4B by in silico and in vitro experiments. Crushed white cabbage and red onion were macerated separately with ethanol to yield respective extracts, and ground coffee was boiled with water to produce aqueous extract. Thin layer chromatography (TLC)–densitometry was used to examine the phytochemicals present in white cabbage, coffee, and red onion extracts. Molecular docking studies were performed to know the interaction of test compounds with PDE4B. TLC-densitometry analysis showed that chlorogenic acid and quercetin were detected as major compounds in coffee and red onion extracts, respectively. In silico studies revealed that alpha-tocopherol (binding free energy (∆Gbind) = −38.00 kcal/mol) has the strongest interaction with PDE4B whereas chlorogenic acid (∆Gbind = −21.50 kcal/mol) and quercetin (∆Gbind = −17.25 kcal/mol) exhibited moderate interaction. In vitro assay showed that the combination extracts (cabbage, coffee, and red onion) had a stronger activity (half-maximal inhibitory concentration (IC50) = 0.12 ± 0.03 µM) than combination standards (sinigrin, chlorogenic acid, and quercetin) (IC50 = 0.17 ± 0.03 µM) and rolipram (IC50 = 0.15 ± 0.008 µM). Thus, the combination extracts are a promising cognitive enhancer by blocking PDE4B activity.

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