Diverse signals converge at MAPK cascades in plant

Zhang, T.; Liu, Y.; Tao, Yang; Zhang, L.; Xu, Shengbao; Xue, Lian; An, Lizhe

doi:10.1016/j.plaphy.2006.06.004

Cited by 132 publications

(86 citation statements)

References 66 publications

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“…Sequence and functional analyses of the Arabidopsis genome have revealed that there are 20 MAPKs, 10 MAPKKs, and 80 MAPKKKs, with a similar repertoire of genes observed in other plant genomes (Ichimura et al, 2002;Hamel et al, 2006;Colcombet and Hirt, 2008). In plants, MAPK cascades have been shown to be involved in signaling pathways and activated by abiotic stresses such as cold, salt, touch, wounding, heat, UV, osmotic shock, and heavy metals (Tena et al, 2001;Zhang et al, 2006;Colcombet and Hirt, 2008;Liu, 2012). Recent studies have suggested that MAPK cascades are involved in several ABA responses, including antioxidant defenses, guard cell signaling, seed germination, and plant growth (Liu and Zhang, 2004;Xing et al, 2008;Jammes et al, 2009;Zong et al, 2009;Wang et al, 2010;Zhang et al, 2010;Huang et al, 2014;Danquah et al, 2015;Lee et al, 2015;Matsuoka et al, 2015).…”

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confidence: 95%

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

et al. 2016

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The mitogen-activated protein kinase (MAPK) cascade is an evolutionarily conserved signal transduction module involved in transducing extracellular signals to the nucleus for appropriate cellular adjustment. This cascade essentially consists of three components: a MAPK kinase kinase (MAPKKK), a MAPK kinase, and a MAPK, connected to each other by the event of phosphorylation. Here, we report the characterization of a MAPKKK, ABA-INSENSITIVE PROTEIN KINASE1 (AIK1), which regulates abscisic acid (ABA) responses in Arabidopsis (Arabidopsis thaliana). T-DNA insertion mutants of AIK1 showed insensitivity to ABA in terms of both root growth and stomatal response. AIK1 functions in ABA responses via regulation of root cell division and elongation, as well as stomatal responses. The activity of AIK1 is induced by ABA in Arabidopsis and tobacco (Nicotiana benthamiana), and the Arabidopsis protein phosphatase type 2C, ABI1, a negative regulator of ABA signaling, restricts AIK1 activity by dephosphorylation. Bimolecular fluorescence complementation analysis showed that MPK3, MPK6, and AIK1 interact with MKK5. The single mutant seedlings of mpk6 and mkk5 have similar phenotypes to aik1, but mkk4 does not. AIK1 was localized in the cytoplasm and shown to activate MKK5 by protein phosphorylation, which was an ABA-activated process. Constitutively active MKK5 in aik1 mutant seedlings complements the ABA-insensitive root growth phenotype of aik1. The activity of MPK6 was increased by ABA in wild-type seedlings, but its activation by ABA was impaired in aik1 and aik1 mkk5 mutants. These findings clearly suggest that the AIK1-MKK5-MPK6 cascade functions in the ABA regulation of primary root growth and stomatal response.

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confidence: 95%

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

et al. 2016

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“…Plants have developed a complex signalling network that senses and protects them from the ever-changing environment to survive. Recent studies have shown that MAPK cascades serve important functions in plant responses to multiple stress conditions (Hirt 1997 wounding, pathogen infection, temperature, drought, salinity); these kinases are also crucial in plant hormone signalling cascades and cell division (Hirt 1997;Zhang et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel mitogen-activated protein kinase kinase gene (MKK2) in the oilseed rape Brassica campestris

Zhang

Wang

et al. 2014

Biologia

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Mitogen-activated protein kinase (MAPK) cascades participate in various processes, including plant growth and development as well as biotic and abiotic stress responses. MAPK kinases (MKKs), which link MPKs and MPKK kinases, are involved in MAPK cascades by mediating various plant stress responses. However, only a few MKKs from Brassica campestris (rape) have been functionally characterized. This study delivers the results from isolation and characterization of a novel gene, MKK2, from rape. Bioinformatics analysis revealed that the cDNA length of MKK2 is 1,344 bp with an open reading frame of 1,068 bp, which encodes a polypeptide containing 355 amino acids. The obtained MKK2 exhibited a predicted molecular mass of 39.3 kDa and an isoelectric point of 6.8. Quantitative real-time polymerase chain reaction analysis revealed that MKK2 expression can be induced by cold and salt. Western blot analysis revealed that MKK2 protein expression can be induced by cold, salt, and UV-B radiation. The MKK2 protein was localized in the nucleus. These results suggest that MKK2 is important for the regulation of cold-and salt-stress responses in plants.

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“…It is speculated that benzylthio sulphur does not accept a hydrogen bond between the inhibitor compound and the enzyme. The crystal structure of Olomoucine (2) in complex with ERK2 displays a conserved hydrogen bond between Met106N and purine N7, and an additional bond from the benzylamino N to Met106O. 7) In addition, the purine ring, Olomoucine (2) and Roscovitine (3), bind in the same region as the purine ring of ATP, and the benzyl group contacts outside of the ATP-binding pocket.…”

Section: Discussionmentioning

confidence: 99%

Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors

Hyun

Havlı́cěk

Strnad

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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Diverse signals converge at MAPK cascades in plant

Cited by 132 publications

References 66 publications

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

Identification of a novel mitogen-activated protein kinase kinase gene (MKK2) in the oilseed rape Brassica campestris

Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors

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