Diverse role of γ-aminobutyric acid in dynamic plant cell responses

Seifikalhor, Maryam; Aliniaeifard, Sasan; Hassani, Seyedeh Batool; Niknam, Vahid; Lastochkina, Oksana

doi:10.1007/s00299-019-02396-z

Cited by 142 publications

(91 citation statements)

References 224 publications

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“…It can be found in Bacteria, Archaea and Eukaryota kingdoms, where it seems to fulfil an incredible variety of roles (Bown & Shelp, ; Feehily & Karatzas, ; Gou, Wang, & Wang, ; Kim, Kashima, Ishikawa, & Yamano, ). In plants, endogenous accumulation of GABA is known to occur in response to many stresses, such as heavy metal accumulation, salinity, heat shock and wounding (Kinnersley & Turano, ; Seifikalhor, Aliniaeifard, Hassani, Niknam, & Lastochkina, ). Furthermore, GABA is a central node in balancing metabolic fluxes between carbon (C) and nitrogen (N) metabolism (Fait, Fromm, Walter, Galili, & Fernie, ; Michaeli & Fromm, ).…”

Section: Introductionmentioning

confidence: 99%

“…A multitude of biological processes seem to be linked to GABA signalling, such as regulation of 14–3–3 genes and control of developmental processes such as germination and pollen tube growth (Lancien & Roberts, ; Palanivelu, Brass, Edlund, & Preuss, ; Sheng, Xiao, Guo, Wu, & Wang, ). This body of evidence delineates GABA as an important molecule in connecting primary metabolism to signalling in plant cells (Bown & Shelp, ; Seifikalhor et al, ). GABA‐dependent modulation of neuronal transmission, or GABAergic signalling, is known to profoundly impact the vertebrate immune system (Barragan, Weidner, Jin, Korpi, & Birnir, ).…”

Section: Introductionmentioning

confidence: 99%

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γ‐Aminobutyric acid and related amino acids in plant immune responses: Emerging mechanisms of action

Tarkowski

Signorelli

Höfte

2020

Plant Cell & Environment

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The entanglement between primary metabolism regulation and stress responses is a puzzling and fascinating theme in plant sciences. Among the major metabolites found in plants, γ-aminobutyric acid (GABA) fulfils important roles in connecting C and N metabolic fluxes through the GABA shunt. Activation of GABA metabolism is known since long to occur in plant tissues following biotic stresses, where GABA appears to have substantially different modes of action towards different categories of pathogens and pests. While it can harm insects thanks to its inhibitory effect on the neuronal transmission, its capacity to modulate the hypersensitive response in attacked host cells was proven to be crucial for host defences in several pathosystems. In this review, we discuss how plants can employ GABA's versatility to effectively deal with all the major biotic stressors, and how GABA can shape plant immune responses against pathogens by modulating reactive oxygen species balance in invaded plant tissues. Finally, we discuss the connections between GABA and other stress-related amino acids such as BABA (β-aminobutyric acid), glutamate and proline. K E Y W O R D SBABA, biotic stress, GABA, glutamate, hypersensitive response, primary metabolism, proline, ROS

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

γ‐Aminobutyric acid and related amino acids in plant immune responses: Emerging mechanisms of action

Tarkowski

Signorelli

Höfte

2020

Plant Cell & Environment

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“…The beneficial role of GABA against stress-induced oxidative damage in various plant species has been often reported 41,48,49 . GABA has also been attributed to cytosolic pH regulation since its biosynthesis consumes protons, thereby reducing acidic conditions [50][51][52] .…”

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confidence: 99%

γ-Aminobutyric acid confers cadmium tolerance in maize plants by concerted regulation of polyamine metabolism and antioxidant defense systems

Seifikalhor

Aliniaeifard

Bernard

et al. 2020

Sci Rep

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Gamma-Aminobutyric acid (GABA) accumulates in plants following exposure to heavy metals. to investigate the role of GABA in cadmium (cd) tolerance and elucidate the underlying mechanisms, GABA (0, 25 and 50 µM) was applied to cd-treated maize plants. Vegetative growth parameters were improved in both cd-treated and control plants due to GABA application. cd uptake and translocation were considerably inhibited by GABA. Antioxidant enzyme activity was enhanced in plants subjected to cd. concurrently GABA caused further increases in catalase and superoxide dismutase activities, which led to a significant reduction in hydrogen peroxide, superoxide anion and malondealdehyde contents under stress conditions. polyamine biosynthesis-responsive genes, namely ornithine decarboxylase and spermidine synthase, were induced by GABA in plants grown under cd shock. GABA suppressed polyamine oxidase, a gene related to polyamine catabolism, when plants were exposed to Cd. Consequently, different forms of polyamines were elevated in Cd-exposed plants following GABA application. The maximum quantum efficiency of photosystem II (F v /f m) was decreased by cd-exposed plants, but was completely restored by GABA to the same value in the control. these results suggest a multifaceted contribution of GABA, through regulation of cd uptake, production of reactive oxygen species and polyamine metabolism, in response to cd stress. Heavy metal (HM) toxicity is considered a major threat to living organisms. HM-polluted soils derived from increasing geologic and anthropogenic activities have significantly impacted the production of high-quality agricultural crops in certain regions of the world. Plants growing on these soils exhibit reduced growth, photosynthetic performance, and yield 1. As a naturally occurring HM pollutant, Cd exposure has been documented in most organisms, particularly plants and humans 2. World fertilizer consumption is increasing and will eventually reach a point where the drawbacks outweigh the benefits 3. The same mechanisms that drive improved plant productivity often create side effects such as environmental contamination. Furthermore, some components of fertilizers, especially Cd, accumulate in both body and food chain, where they remain for an extended period and causes adverse health effects 4. Therefore, fertilizers containing very high levels of Cd (417 mg/kg) threaten human health by accumulation in important crop such as maize 5. Maize, as one of the most popular cereal grain, is widely cultivated across the world. Maize is also produced at an industrial scale as a key input in various products such as syrups, soft drinks and charcoals 6,7. Therefore, there is a strong incentive to minimize the toxic effects of Cd in maize.

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“…The association between GABA and the TCA cycle intermediates is to replenish the TCA cycle via the GABA shunt and to maintain amino acid biosynthesis under low levels of energy 49,50,67 . GABA accumulation has been associated with abiotic stresses 50,68 . Increased GABA levels were shown in wheat and barley during freezing 69 .…”

Section: Discussionmentioning

confidence: 99%

Correlation-based network analysis combined with machine learning techniques highlight the role of the GABA shunt in Brachypodium sylvaticum freezing tolerance

Toubiana

Sade

Liu

et al. 2020

Sci Rep

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Perennial grasses will account for approximately 16 billion gallons of renewable fuels by the year 2022, contributing significantly to carbon and nitrogen sequestration. However, perennial grasses productivity can be limited by severe freezing conditions in some geographical areas, although these risks could decrease with the advance of climate warming, the possibility of unpredictable early cold events cannot be discarded. We conducted a study on the model perennial grass Brachypodium sylvaticum to investigate the molecular mechanisms that contribute to cold and freezing adaption. The study was performed on two different B. sylvaticum accessions, Ain1 and Osl1, typical to warm and cold climates, respectively. Both accessions were grown under controlled conditions with subsequent cold acclimation followed by freezing stress. For each treatment a set of morphological parameters, transcription, metabolite, and lipid profiles were measured. State-of-the-art algorithms were employed to analyze cross-component relationships. Phenotypic analysis revealed higher adaption of Osl1 to freezing stress. Our analysis highlighted the differential regulation of the TCA cycle and the GABA shunt between Ain1 and Osl1. Osl1 adapted to freezing stress by repressing the GABA shunt activity, avoiding the detrimental reduction in fatty acid biosynthesis and the concomitant detrimental effects on membrane integrity.The increase in energy demand coupled with the environmental impact of fossil fuels has led to the expansion of programs using perennial species as an alternative source of energy. In this context, perennial grasses, traditionally used as forage and turf, have become the preferred candidates for biomass cropping systems attributed to their ability to grow under low input conditions and high interception of sunlight 1 . Predictions showed that perennial grasses will account for approximately 16 billion gallons of renewable fuels by the year 2022 2,3 . Perennial grasses have shown to support carbon (C) and nitrogen (N) sequestration in the soil 4-6 , contributing to mitigate climate change and environmental degradation 7-9 . Brachypodium sylvaticum is a perennial grass with a simple genome, self-fertility, a short life cycle, and low growth requirements. Its recently released genome, expression gene atlas 10 and well established genetic transformation have made it an efficient model to study the genetic, molecular, and physiological components of perennial grasses 11,12 .Unfavorable winter conditions, including freezing, limit the geographical range of many important crops and reduce their productivity due to growth repression 13,14 . Low temperatures combined with high light intensity provoke the inhibition of the photosystem II and ROS production leading to oxidative stress 15 . In addition, ice formation in the apoplast induces both, cell membrane integrity stress and osmotic stress 16 . The plant's response to low temperatures involves extensive reprograming of gene expression via transcription factors 17 , resulting in co...

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Diverse role of γ-aminobutyric acid in dynamic plant cell responses

Cited by 142 publications

References 224 publications

γ‐Aminobutyric acid and related amino acids in plant immune responses: Emerging mechanisms of action

γ‐Aminobutyric acid and related amino acids in plant immune responses: Emerging mechanisms of action

γ-Aminobutyric acid confers cadmium tolerance in maize plants by concerted regulation of polyamine metabolism and antioxidant defense systems

Correlation-based network analysis combined with machine learning techniques highlight the role of the GABA shunt in Brachypodium sylvaticum freezing tolerance

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