Diverse profiles of N-acyl-homoserine lactones in biofilm forming isolates of<i>Cronobacter sakazakii</i>

Tall, Ben D.; Chase, Hannah R.; Gopinath, Gopal

doi:10.1080/21505594.2016.1240861

Cited by 2 publications

(2 citation statements)

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“…In another recent study, long chain AHLs (C6-C18 in length) were identified and chemically characterized in C. sakazakii [124,125]. In vitro results demonstrated that these AHLs appeared sufficient to be detected after 6 h of incubation [126].…”

Section: Quorum Sensing Signaling Systemsmentioning

confidence: 97%

The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence

et al. 2020

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Cronobacter species are considered an opportunistic group of foodborne pathogenic bacteria capable of causing both intestinal and systemic human disease. This review describes common virulence themes shared among the seven Cronobacter species and describes multiple exoproteins secreted by Cronobacter, many of which are bacterial toxins that may play a role in human disease. The review will particularly concentrate on the virulence factors secreted by C. sakazakii, C. malonaticus, and C. turicensis, which are the primary human pathogens of interest. It has been discovered that various species-specific virulence factors adversely affect a wide range of eukaryotic cell processes including protein synthesis, cell division, and ion secretion. Many of these factors are toxins which have been shown to also modulate the host immune response. These factors are encoded on a variety of mobile genetic elements such as plasmids and transposons; this genomic plasticity implies ongoing re-assortment of virulence factor genes which has complicated our efforts to categorize Cronobacter into sharply defined genomic pathotypes.

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Section: Quorum Sensing Signaling Systemsmentioning

confidence: 97%

The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence

et al. 2020

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“… Ye et al (2016) used proteomics to compare protein expression during the biofilm and planktonic modes of bacteria to identify unique profiles of protein expression profiles related to biofilms. Recently, researchers also found that quorum sensing signaling molecules acyl homoserine lactones contribute to biofilm formation ( Tall et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The Glutaredoxin Gene, grxB, Affects Acid Tolerance, Surface Hydrophobicity, Auto-Aggregation, and Biofilm Formation in Cronobacter sakazakii

Ling¹,

Zhang²,

Li³

et al. 2018

Front. Microbiol.

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Cronobacter species are foodborne pathogens that can cause neonatal meningitis, necrotizing enterocolitis, and sepsis; they have unusual abilities to survive in environmental stresses such as acid stress. However, the factors involved in acid stress responses and biofilm formation in Cronobacter species are poorly understood. In this study, we investigated the role of grxB on cellular morphology, acid tolerance, surface hydrophobicity, auto-aggregation (AAg), motility, and biofilm formation in Cronobacter sakazakii. The deletion of grxB decreased resistance to acid stresses, and notably led to weaker surface hydrophobicity, AAg, and biofilm formation under normal and acid stress conditions, compared with those of the wild type strain; however, motility was unaffected. Therefore, grxB appears to contribute to the survival of C. sakazakii in acid stresses and biofilm formation. This is the first report to provide valuable evidence for the role of grxB in acid stress responses and biofilm formation in C. sakazakii.

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Diverse profiles of N-acyl-homoserine lactones in biofilm forming isolates ofCronobacter sakazakii

Cited by 2 publications

References 9 publications

The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence

The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence

The Glutaredoxin Gene, grxB, Affects Acid Tolerance, Surface Hydrophobicity, Auto-Aggregation, and Biofilm Formation in Cronobacter sakazakii

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