Diverse Physiological Functions and Regulatory Mechanisms for Signal-Transducing Small GTPases

Satoh, Takaya

doi:10.3390/ijms21197291

Cited by 2 publications

(1 citation statement)

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“…In addition, it is believed that the action of GEFs is specific not only to their substrates, i.e. RHO GTPases, but also to the cell types and upstream signals [ 25 ]. For example, GEFs act immediately upstream of RHO GTPases, providing a direct link between the activation of RHO and various cell surface receptors for growth factors, adhesion molecules, cytokines, and G protein-coupled receptors [ 23 ].In addition, RHO GEFs play an essential scaffolding function and coordinate downstream signaling in response to upstream cell stimuli by interacting with a definite set of targets and bringing these effector proteins into the vicinity of the RHO GTPases which they activate [ 24 ].…”

Section: Rho Gtpase Family In Biologymentioning

confidence: 99%

RHO GTPase family in hepatocellular carcinoma

Wang

Rao

et al. 2022

Exp Hematol Oncol

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RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular transport. Recent studies indicate that RHO GTPases participate in the proliferation, migration, invasion and metastasis of cancer, playing an essential role in the tumorigenesis and progression of hepatocellular carcinoma (HCC). This review first introduces the classification, structure, regulators and functions of RHO GTPases, then dissects its role in HCC, especially in migration and metastasis. Finally, we summarize inhibitors targeting RHO GTPases and highlight the issues that should be addressed to improve the potency of these inhibitors.

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Section: Rho Gtpase Family In Biologymentioning

confidence: 99%