Diverse imaging findings of Lhermitte–Duclos disease

Han, Cheng Ta; Zhang, Y.; Luo, Ying; Li, W.

doi:10.1016/j.crad.2022.08.134

Cited by 2 publications

(6 citation statements)

References 27 publications

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“…Although tiger stripe appearance is highly specific, it has been observed in other lesions [13] . In addition, the absence of significant enhancement is characteristic of LDD, which suggests no significant blood-brain barrier damage and no extracellular edema [14] . However, enhancement has been reported [15] .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a recent study suggested that tiger stripes tend to be present in cases of LDD accompanied by other CS neoplasms, while in cases where LDD is present alone, atypical radiological imaging is more common [14] .…”

Section: Discussionmentioning

confidence: 99%

“…LDD can exhibit variable diffusivity on DWI [14] . DWI and ADC images in our patient showed no diffusion restriction.…”

Section: Discussionmentioning

confidence: 99%

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Lhermitte-Duclos disease in a 51-year old patient

Abdelrahman,

Abass,

Abdalla

et al. 2024

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lhermitte-Duclos disease in a 51-year old patient

Abdelrahman,

Abass,

Abdalla

et al. 2024

Radiology Case Reports

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“…The finding that lesion enhancements and linear striations were observed in 14.9% and 58.7% of cases is consistent with a previous small-scale review of 21 patients that found that 61.9% of the patients manifested the classical layered pattern. [ 16 ] However, the tiger-stripe appearance is not unique to LDD, and it should be combined with other typical signs of LDD to enhance diagnosis. [ 16 ] Although MRI seems to have a reasonable level of specificity for LDD, recognizing that other lesions may mimic the MRI findings of LDD is important.…”

Section: Discussionmentioning

confidence: 99%

“…[ 16 ] However, the tiger-stripe appearance is not unique to LDD, and it should be combined with other typical signs of LDD to enhance diagnosis. [ 16 ] Although MRI seems to have a reasonable level of specificity for LDD, recognizing that other lesions may mimic the MRI findings of LDD is important. [ 8 , 21 ]…”

Section: Discussionmentioning

confidence: 99%

Lhermitte–Duclos disease: A systematic review

Alanazi,

Alanezi,

Aljofan

et al. 2023

Surgical Neurology International

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Background: Lhermitte–Duclos disease (LDD) is a rare tumor, with only about 300 reported cases. It often shows comorbidity with Cowden syndrome (CS); however, it can occur by itself. Radiologically, the “tiger-stripe” appearance is considered pathognomonic. Surgical resection remains the mainstay of treatment. This report aims to describe the clinical and radiological characteristics of LDD and its relationship with CS according to age group. Methods: PubMed electronic databases were searched in August 2022. The search terms included “Lhermitte– Duclos disease” and “dysplastic gangliocytoma,” which yielded 297 and 103 research articles, respectively. The articles were collected and reviewed by three researchers. Results: Out of 400 identified articles, we analyzed 302 reported cases. The mean age at presentation was 33.6 ± 16 years; 171 patients (56.6%) were female, and 123 (40.7%) were male. The most commonly reported symptom was headache (174 patients, 57.6%), followed by ataxia (109, 36.1%). In addition, 99 cases (32.8%) were associated with CS, and 60 (19.9%) had a confirmed phosphatase and tensin homolog (PTEN) mutation. A tiger-stripe appearance was observed in 208 cases (58.7%); surgical resection was performed in 64.2% of the cases. Mortality and recurrence rates were 4.3% and 8.6%, respectively. No statistically significant difference was found between adult- and pediatric-onset LDD for the association with CS (P = 0.128). Conclusion: Our findings suggest that adult and pediatric LDD have major commonalities; however, further prospective studies are warranted.

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Diverse imaging findings of Lhermitte–Duclos disease

Cited by 2 publications

References 27 publications

Lhermitte-Duclos disease in a 51-year old patient

Lhermitte-Duclos disease in a 51-year old patient

Lhermitte–Duclos disease: A systematic review

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