Diverse factors influencing angiotensin metabolism during ACE inhibition: insights from molecular biology and genetic studies

The effects of sublingual administration of captopril on parameters of exercise test and neurohormonal activation in patients with stable angina pectoris

“…In the second part of our study, we investigated neurohormortal activation due to exercise and the effects of sublingual C administration on it in patients with CAD whose left ventricular systolic function was normal or who had left ventricular dysfunction of varying degrees. Recently, a number of investigators have reported the presence of an endogenous RAAS in cardiac muscle, vascular smooth muscle, and endothelial cells [20,21]. The studies indicated that this system increases cardiac contractility and reduces coronary blood flow, leading to vasoconstriction [21 ].…”