Diverse effects of Porphyromonas gingivalis on human osteoclast formation

Periodontal and Systemic Responses in Various Mice Models of Experimental Periodontitis: Respective Roles of Inflammation Duration and Porphyromonas gingivalis Infection

“…2 In vitro studies demonstrated a dual effect of Pg infection on the balance between bone apposition and resorption by differentially stimulating toll-like receptors and the RANK pathway in osteoblasts and osteoclasts. 38,39 These data reflect the complex control of alveolar bone resorption during periodontitis that involves various molecules and cell types. 40 In ligature models, MMP-9 expression colocalized with TRAP activity in many osteoclastic cells, especially those close to the periodontal pocket, which supports an intense degradation activity in the matrix.…”

“…These data suggest that bone loss severity does not necessarily reflect the bone resorptive activity 2 . In vitro studies demonstrated a dual effect of Pg infection on the balance between bone apposition and resorption by differentially stimulating toll‐like receptors and the RANK pathway in osteoblasts and osteoclasts 38,39 . These data reflect the complex control of alveolar bone resorption during periodontitis that involves various molecules and cell types 40 .…”

Leukocyte Inclusion within a Platelet Rich Plasma-Derived Fibrin Scaffold Stimulates a More Pro-Inflammatory Environment and Alters Fibrin Properties

“…At the same time, this cytokine stimulates matrix metalloproteinases, therefore increasing matrix degradation. IL-8 in turn, may induce neutrophil chemotaxis and activation [ 40 – 42 ]. Meanwhile, TNF-α and IL-1β have also a significant role in bone loss, playing a central role in inflammatory reaction [ 28 , 43 ].…”

A challenge with Porphyromonas gingivalis differentially affects the osteoclastogenesis potential of periodontal ligament fibroblasts from periodontitis patients and non‐periodontitis donors

“…However, Scheres et al. () mimicked a long term infection by culturing osteoclast precursors in the presence of Pg conditioned fibroblast medium. They also found inhibition of osteoclast formation in the presence of M‐CSF and RANKL.…”