Diverse C-6 substituted 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines: synthesis, in vitro anticancer evaluation and in silico studies

Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer

“…( Hey and Williams, 1950 , Nunn and Schofield, 1952 ; Kouznetsov et al., 2012 , 2017 ; Yamaguchi et al., 2016 ; Pang et al., 2017 ; Zhang et al., 2017a , 2017b ; Roder et al., 2019 ) yellow solid was obtained by column chromatography (eluent: EtOAc/petroleum ether = 1/4) with 58% isolated yield (30.0 mg). m. p. = 128-130°C.…”

“…( Hey and Williams, 1950 , Nunn and Schofield, 1952 ; Kouznetsov et al., 2012 , 2017 ; Yamaguchi et al., 2016 ; Pang et al., 2017 ; Zhang et al., 2017a , 2017b ; Roder et al., 2019 ) yellow oil was obtained by column chromatography (eluent: EtOAc/petroleum ether = 1/4) with 46% isolated yield (25.3 mg). 1 H NMR (500 MHz, CDCl 3 ) δ 8.74 (d, J = 4.1 Hz, 1H), 8.65 (d, J = 7.9 Hz, 1H), 8.40 (s, 1H), 8.19 (d, J = 8.5 Hz, 1H), 8.04 (d, J = 8.2 Hz, 1H), 7.88 (t, J = 7.7 Hz, 1H), 7.73 (t, J = 7.6 Hz, 1H), 7.58 (t, J = 7.5 Hz, 1H), 7.36 (t, J = 6.2 Hz, 1H), 2.80 (s, 3H).…”

“…Pyridines are among the most representative heterocycles in pharmaceuticals, materials, natural product molecules, and organic functional materials ( Yadav and Reddy, 2003 , Chen et al, 2006 ; Moser et al., 2008 ; Misale et al., 2012 ; Afeli et al., 2013 ; Felding et al., 2014 ; Kouznetsov et al., 2017 ; Gil-Martins et al., 2020 ). As a result, new methods for the construction of functionalized pyridines from abundant precursors are an important synthetic goal ( Nakao, 2011 ; Murakami et al., 2017 ; Wang et al., 2021 , Zhou and Jiao, 2021 ).…”

A Reusable Efficient Green Catalyst of 2D Cu-MOF for the Click and Knoevenagel Reaction

“…In the literature, there are few reported procedures [ 45 , 46 ] for the CPA ligand synthesis, but herein, we have modified the synthetic procedure for better yield. A mixture of the appropriately Pyridine-4-carbaldehyde (5 mmol) and the appropriately substituted aniline (5 mmol) in dry toluene (50 mL) is refluxed for 5 h in the presence of molecular sieves (75 g; Davison, grade 514Å, effective pore size 4, 8–12 mesh beads).…”

Preparation and DFT Study for New Three-Ring Supramolecular H-Bonded Induced Liquid Crystal Complexes

“…Finally, supramolecular complexes were prepared by mixing equimolar ratios of a particular Schiff base with the para-alkoxy benzoic acid and then subjected to melting to ensure the formation of the complexes (see Scheme 2). The compounds were identified by their reported melting points: A (98 C) (Boyer et al, 2007), B (100 C) (Poronik et al, 2017), C (88 C) (Kouznetsov et al, 2017), D (74 C) (Krishna Murthy et al, 2018), E (80 C) (Boyer et al, 2007), and F (82 C).…”