Diverse biological roles of the tetrathiomolybdate anion

Maiti, Biplab K.; Moura, José J. G.

doi:10.1016/j.ccr.2020.213635

Cited by 22 publications

(33 citation statements)

References 192 publications

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“…HSA is one of the most important copper transport proteins in blood, known as labile Cu pool in extracellular space, and ensures copper homeostasis in human body by utilizing the ATCUN tag ( Harford and Sarkar, 1997 ; Laussac and Sarkar, 1984 ). Otherwise, dysregulation of Cu homeostasis leads to several number of human diseases, which are WD, cancer, diabetes, and Alzheimer's disease (AD) ( Lowe et al., 2017 ; Maiti and Moura, 2020 ). Histamin is one class of natural host defense peptide, possessing ATCUN site that involves in antimicrobial activity ( Conklin et al., 2017 ).…”

Section: Biological Role Of M-atcun Motif In Proteins/peptidesmentioning

confidence: 99%

“…Prior to entry into cell, Cu is present mainly as Cu II state and ensures copper homeostasis under physiological conditions by one of the most important proteins, albumin, which represents as labile Cu pool in human blood ( Harford and Sarkar, 1997 ; Laussac and Sarkar, 1984 ). This labile copper pool has clinically significance as potential markers of copper-related pathologies ( Lowe et al., 2017 ; Maiti and Moura, 2020 ). Therefore, measurement of this labile copper pool in biological samples is of considerable interest by fluorescence study.…”

Section: Applications Of M-atcun Derivativesmentioning

confidence: 99%

“…The interest is to drive the ATCUN derivatives toward cellular targets mainly cytosol and nucleus, and these should be reached to the target position in an active form. In cellular assays, like cis-Pt ( Lasorsa et al., 2019 ) and TTM drug ( Maiti and Moura, 2020 ), ATCUN drugs may also interact with intercellular proteins, mainly, copper trafficking proteins such as metallothioneins (MTs; as a biological strong Cu I -chelators) and glutathione (GSH; as a biological copper reducer) ( Boal and Rosenzweig, 2009 ). Recently, Santoro et al.…”

Section: Conclusion and Future Challengesmentioning

confidence: 99%

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Designed Metal-ATCUN Derivatives: Redox- and Non-redox-Based Applications Relevant for Chemistry, Biology, and Medicine

et al. 2020

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Summary The designed “ATCUN” motif (amino-terminal copper and nickel binding site) is a replica of naturally occurring ATCUN site found in many proteins/peptides, and an attractive platform for multiple applications, which include nucleases, proteases, spectroscopic probes, imaging, and small molecule activation. ATCUN motifs are engineered at periphery by conjugation to recombinant proteins, peptides, fluorophores, or recognition domains through chemically or genetically, fulfilling the needs of various biological relevance and a wide range of practical usages. This chemistry has witnessed significant growth over the last few decades and several interesting ATCUN derivatives have been described. The redox role of the ATCUN moieties is also an important aspect to be considered. The redox potential of designed M-ATCUN derivatives is modulated by judicious choice of amino acid (including stereochemistry, charge, and position) that ultimately leads to the catalytic efficiency. In this context, a wide range of M-ATCUN derivatives have been designed purposefully for various redox- and non-redox-based applications, including spectroscopic probes, target-based catalytic metallodrugs, inhibition of amyloid-β toxicity, and telomere shortening, enzyme inactivation, biomolecules stitching or modification, next-generation antibiotic, and small molecule activation.

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Section: Biological Role Of M-atcun Motif In Proteins/peptidesmentioning

confidence: 99%

Section: Applications Of M-atcun Derivativesmentioning

confidence: 99%

Section: Conclusion and Future Challengesmentioning

confidence: 99%

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Designed Metal-ATCUN Derivatives: Redox- and Non-redox-Based Applications Relevant for Chemistry, Biology, and Medicine

et al. 2020

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“…ATN-224 also inhibits intracellular SOD1 activity at micromolar concentrations (IC 50 : 1.4~185 μM), but has specificity for copper binding, all of which makes it one of the most popular SOD1 inhibitors [ 62 , 64 ]. Every sulfur atom in tetrathiomolybdate can coordinate with copper and may then form metal clusters with copper enzymes, thereby inhibiting the activity of copper proteins, such as SOD1, cytochrome c oxidase, and ceruloplasmin [ 65 , 66 ]. Therefore, ATN-224 may also interfere with intracellular copper homeostasis or inhibit other copper enzymes.…”

Section: Inorganic Sod1 Inhibitors With Anti-cancer Prospectsmentioning

confidence: 99%

Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment

Wang

et al. 2021

Molecules

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Reactive oxygen species (ROS) are rapidly eliminated and reproduced in organisms, and they always play important roles in various biological functions and abnormal pathological processes. Evaluated ROS have frequently been observed in various cancers to activate multiple pro-tumorigenic signaling pathways and induce the survival and proliferation of cancer cells. Hydrogen peroxide (H2O2) and superoxide anion (O2•−) are the most important redox signaling agents in cancer cells, the homeostasis of which is maintained by dozens of growth factors, cytokines, and antioxidant enzymes. Therefore, antioxidant enzymes tend to have higher activity levels to maintain the homeostasis of ROS in cancer cells. Effective intervention in the ROS homeostasis of cancer cells by chelating agents or metal complexes has already developed into an important anti-cancer strategy. We can inhibit the activity of antioxidant enzymes using chelators or metal complexes; on the other hand, we can also use metal complexes to directly regulate the level of ROS in cancer cells via mitochondria. In this review, metal complexes or chelators with ROS regulation capacity and with anti-cancer applications are collectively and comprehensively analyzed, which is beneficial for the development of the next generation of inorganic anti-cancer drugs based on ROS regulation. We expect that this review will provide a new perspective to develop novel inorganic reagents for killing cancer cells and, further, as candidates or clinical drugs.

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“…[3] The investigations performed in the last five decades by several research groups have revealed the importance of sulfidomolybdates in diverse areas of science like hydrodesulfurization catalysis, bioinorganic chemistry, medicine, organic synthesis, and solid state 33 S NMR spectroscopy. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] As part of a long-standing research activity we have been investigating the synthetic chemistry and structural aspects of the group(VI) metal chalcogenides. Our contributions in this area have resulted in the synthesis, spectral characterization, and structural identification of several tetrasulfidomolybdates [20,21] and the corresponding W analogues, [22][23][24] charge balanced by organic ammonium cations.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization and Crystal Structures of Five Organic Ammonium Tetrasulfidomolybdates

et al. 2021

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The syntheses, spectral characterization and crystal structures of five organic ammonium tetrasulfidomolybdates namely (C 4 H 12 N) 2 [MoS 4 ] 1 (C 4 H 12 N is 2-methyl-propan-2-aminium), (C 5 The charge balancing cations in 1-3 are protonated methyl substituted propanamines, while the dications of 4 and 5 are derived from a tetraamine and a cyclic diamine respectively. The crystal structures of 1 to 5 consist of an unique tetrahedral [MoS 4 ] 2À dianion charge balanced by a crystallographically independent organic dication for all compounds excepting 1 which contains a pair of unique (2-methylpropan-2-aminium) monocations. Although all the compounds are crystallized from aqueous solutions, 1 to 4 are anhydrous while 5 is a hemihydrate. In the crystal structures, the organic cations and the tetrasulfidomolybdate dianions are interlinked with the aid of several NÀ H⋅⋅⋅S and CÀ H⋅⋅⋅S hydrogen bonding interactions. In addition to NÀ H⋅⋅⋅S and CÀ H⋅⋅⋅S hydrogen bonds, compound 5 exhibits NÀ H⋅⋅⋅O and OÀ H⋅⋅⋅O hydrogen bonding interactions involving the H 2 O molecule, which interlinks pairs of anions with pairs of cations. Hirshfeld surface analyses were performed which reveal distortion of the [MoS 4 ] 2À tetrahedra, extensive S⋅⋅⋅H interactions between the anions and cations and also H⋅⋅⋅H contacts between the cations. A comparative study of the structural chemistry of thirty-eight tetrasulfidomolybdates is described.

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Diverse biological roles of the tetrathiomolybdate anion

Cited by 22 publications

References 192 publications

Designed Metal-ATCUN Derivatives: Redox- and Non-redox-Based Applications Relevant for Chemistry, Biology, and Medicine

Designed Metal-ATCUN Derivatives: Redox- and Non-redox-Based Applications Relevant for Chemistry, Biology, and Medicine

Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment

Synthesis, Spectral Characterization and Crystal Structures of Five Organic Ammonium Tetrasulfidomolybdates

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