“…Nonetheless, hPSC-derived models can expedite evaluation of preclinical toxicity and safety as well as the effective planning of clinical trials compared with regular modeling systems. Specifically, organoids are stem cell-originated self-structured three-dimensional cultures in vitro and imitate the physiological environment of natural organs [108] , [109] , [110] . Lung organoid constructed by pneumocytes expressing ACE2 mimicked interferon-mediated inflammatory response in SARS-CoV-2 infection with less surface surfactants and apoptosis in alveolar cells [111] .…”