Diverse biological and engineering strategies towards organ regeneration

Abstract

Organ regeneration is an important, fascinating, and old topic while much remains unknown in spite of extensive investigations for decades. From March 25th to 27th, 2021, the Third Chinese Symposium on Organ Regeneration took place in the beautiful ocean city of Zhoushan, Zhejiang, China. This biennial conference attracted ~ 300 academic attendees: students, postdoctoral fellows, and principal investigators, in addition to few industrial investigators. The mixed live and virtual talks covered the broad field of organ regeneration from different animal organisms to human organoids, and concluded with some impressive advances on inflammatory signaling, regenerative signaling mechanisms, new technologies, and applications for organ regeneration.

Tissue repair strategies: What we have learned from COVID-19 in the application of MSCs therapy

“…Nonetheless, hPSC-derived models can expedite evaluation of preclinical toxicity and safety as well as the effective planning of clinical trials compared with regular modeling systems. Specifically, organoids are stem cell-originated self-structured three-dimensional cultures in vitro and imitate the physiological environment of natural organs [108] , [109] , [110] . Lung organoid constructed by pneumocytes expressing ACE2 mimicked interferon-mediated inflammatory response in SARS-CoV-2 infection with less surface surfactants and apoptosis in alveolar cells [111] .…”