Diverse Ag(i) complexes constructed from methyl-4-(5-halopyrimidin-2-ylcarbamoyl)benzoate ligands: roles of the halogen atom and anion

Wu, Ching-Chou; Sie, Ming-Jhe; Hsiao, Hui-Lin; Chen, Jhy‐Der

doi:10.1039/c1ce05102d

Cited by 18 publications

(14 citation statements)

References 36 publications

(6 reference statements)

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“…2). In the crystal structure the amide group of the title compound adopts the cis conformation, which is in marked contrast to the trans conformation found in the Ag complex (Wu et al, 2011).…”

Section: S1 Commentcontrasting

confidence: 58%

“…For silver complexes of the title compound, see: Wu et al (2011). For the conformation of the amide group in similar compounds, see: Forbes et al (2001); Oertli et al (1992).…”

Section: Related Literaturementioning

confidence: 99%

“…The silver(I) complex containg methyl 4-(5-chloropyrimidin-2-ylcarbamoyl)benzoate ligand has been reported, which shows a two-dimensional network (Wu et al, 2011). Within this project the crystal structure of the title compound was determined (Fig.…”

Section: S1 Commentmentioning

confidence: 99%

“…The title compound was prepared according to a published procedure (Wu et al, 2011). Block crystals suitable for X-ray crystallography were obtained by slow evaporation of the solvent from a solution of the title compound in methanol.…”

Section: S2 Experimentalmentioning

confidence: 99%

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Methyl 4-[(5-chloropyrimidin-2-yl)carbamoyl]benzoate

Yeh

et al. 2011

Acta Cryst E

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Molecules of the title compound, C13H10ClN3O3, form centrosymmetric dimers via intermolecular N—H⋯N hydrogen bonds generating an R 2 2(8) motif. The dimers are further connected through an O⋯Cl—C halogen bond [O⋯Cl = 3.233 (1) Å and O⋯Cl—C = 167.33 (1)°] into a chain along [110]. The secondary amide group adopts a cis conformation. Weak C—H⋯N hydrogen bonds among the methyl benzoate and pyrimidyl rings are also observed in the crystal structure.

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Section: S1 Commentcontrasting

confidence: 58%

“…For silver complexes of the title compound, see: Wu et al (2011). For the conformation of the amide group in similar compounds, see: Forbes et al (2001); Oertli et al (1992).…”

Section: Related Literaturementioning

confidence: 99%

Section: S1 Commentmentioning

confidence: 99%

Section: S2 Experimentalmentioning

confidence: 99%

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Methyl 4-[(5-chloropyrimidin-2-yl)carbamoyl]benzoate

Yeh

et al. 2011

Acta Cryst E

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“…The title compound was prepared according to a published procedure (Wu et al, 2011). Plate like crystals suitable for Xray crystallography were obtained by slow evaporization of the solvent from a solution of the title compound in methanol.…”

Section: S2 Experimentalmentioning

confidence: 99%

Methyl 4-[(pyrimidin-2-yl)carbamoyl]benzoate

Lu¹,

Wu²,

Yeh³

et al. 2011

Acta Cryst E

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In vitro investigation of biophysical interactions between Ag(I) complexes of bis(methyl)(thia/selena)salen and ct‐DNA via multi‐spectroscopic, physicochemical and molecular docking methods along with cytotoxicity study

et al. 2021

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Four silver(I) (Ag(I)) complexes: 1.PF6, 2.PF6, 1.ClO4 and 2.ClO4 of bis(methyl)thia salen (1) and bis (methyl)selena salen (2) with two different counter anions (PF6− and ClO4−) have been investigated for DNA binding properties. In vitro interactional association between the Ag(I) complexes and ct‐DNA has been examined by performing spectroscopic titrations on absorption spectrophotometer and fluorescence spectrophotometer. A competitive binding study has also been done using a fluorescence spectrophotometer with ethidium bromide as a classical intercalator. The spectroscopic methods revealed a major groove. Viscometry and agarose gel electrophoresis experiments have also been performed as physicochemical methods to confirm the binding of complex molecules with DNA. Molecular docking analysis has been executed to obtain the theoretical insight into the mode of binding. The docking study demonstrated the major groove binding of all four complexes to the DNA with electrostatic metal–phosphate interactions (between the metal and the backbone of DNA) and hydrophobic interactions. Cytotoxicity of the complexes has been studied on the Human Fibroblast foreskin (HFF) cell line. The cytotoxicity results showed positive gesture for moving ahead to the next level of screening; the values were above 10 μM which are appreciated for the normal cell lines.

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Diverse Ag(i) complexes constructed from methyl-4-(5-halopyrimidin-2-ylcarbamoyl)benzoate ligands: roles of the halogen atom and anion

Cited by 18 publications

References 36 publications

Methyl 4-[(5-chloropyrimidin-2-yl)carbamoyl]benzoate

Methyl 4-[(5-chloropyrimidin-2-yl)carbamoyl]benzoate

Methyl 4-[(pyrimidin-2-yl)carbamoyl]benzoate

In vitro investigation of biophysical interactions between Ag(I) complexes of bis(methyl)(thia/selena)salen and ct‐DNA via multi‐spectroscopic, physicochemical and molecular docking methods along with cytotoxicity study

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