Diverging breast cancer mortality rates in relation to screening? A comparison of Nijmegen to Arnhem and the Netherlands, 1969-1997

Broeders, Mireille J. M.; Peer, Petronella G. M.; Straatman, Huub; Beex, L.V.A.M.; Hendriks, Jan H. C. L.; Holland, Roland; Verbeek, A.L.M.

doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1186>3.0.co;2-b

Cited by 21 publications

(13 citation statements)

References 38 publications

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“…For the birth cohort analyses, if we replaced the six-year follow-up data with the nine-year follow-up data, the pooled RR for birth cohort studies among women 50–69 was still non-significant (RR = 0.95 with 95% CI (0.77, 1.17)) [24], [25]. In the geographical analyses, we analyzed Van Dijick et al, 1997 instead of Broeders et al, 2001, but both studies reported non-significant, reduction in breast cancer mortality [31], [32]. In the geographical-historical hybrids, we substituted the Jorgensen et al, 2010 and Kalager et al, 2010 studies in place of the Olsen 2005 and 2013 studies [29], [30], [33], [34].…”

Section: Discussionmentioning

confidence: 94%

“…Although Jorgensen et al, 2010 reported the longer follow-up, Olsen et al, 2005a was retained in the primary meta-analysis because it analyzed incidence-breast cancer mortality [29], [30]. Van Dijick et al, 1997 and Broeders et al, 2001, both reported on screening in Nijmegen, the Netherdlands, but Van Dijick was retained in the primary analyses because it analyzed incident breast cancer mortality and reported relative risks without adjustments [31], [32]. Similarly, Olsen et al, 2012 and Kalager et al, 2010 reported on similar geographical regions in Norway, but Olsen et al, 2012 was retained in the primary analyses because it had a longer follow-up period [33], [34].…”

Section: Methodsmentioning

confidence: 99%

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Screening Mammography & Breast Cancer Mortality: Meta-Analysis of Quasi-Experimental Studies

Irvin

Kaplan

2014

PLoS ONE

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BackgroundThe magnitude of the benefit associated with screening has been debated. We present a meta-analysis of quasi-experimental studies on the effects of mammography screening.MethodsWe searched MEDLINE/PubMed and Embase for articles published through January 31, 2013. Studies were included if they reported: 1) a population-wide breast cancer screening program using mammography with 5+ years of data post-implementation; 2) a comparison group with equal access to therapies; and 3) breast cancer mortality. Studies excluded were: RCTs, case-control, or simulation studies. We defined quasi-experimental as studies that compared either geographical, historical or birth cohorts with a screening program to an equivalent cohort without a screening program. Meta-analyses were conducted in Stata using the metan command, random effects. Meta-analyses were conducted separately for ages screened: under 50, 50 to 69 and over 70 and weighted by population and person-years.ResultsAmong 4,903 published papers that were retrieved, 19 studies matched eligibility criteria. Birth cohort studies reported a significant benefit for women screened

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Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Screening Mammography & Breast Cancer Mortality: Meta-Analysis of Quasi-Experimental Studies

Irvin

Kaplan

2014

PLoS ONE

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“…Decreases in breast cancer mortality have been variously reported following the introduction of mammographic screening on a regional level (Tornberg et al, 1994;Quinn and Allen, 1995;Garne et al, 1997;Barchielli and Paci, 2001;Broeders et al, 2001;Tabar et al, 2001;Duffy et al, 2002). Randomised prospective trials indicate that benefits in terms of cumulative breast cancer mortality start to emerge 4 -10 years after randomisation (Nyström et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Breast cancer mortality trends in two areas of the province of Florence, Italy, where screening programmes started in the 1970s and 1990s

et al. 2004

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We compared breast cancer mortality rates in the period 1985 -2000 in two areas of the province of Florence, Italy, where breast cancer screening programmes started in the 1970s (early screening (ES) area) and in 1990s (late screening (LS) area). The overall age-standardised mortality decreased in the whole period by 40.9% in the ES area (Po0.001), and by 11.3% in the LS area (P ¼ 0.030). Significant decreases in the ES area were detected in groups aged 45 -54 years (61.1%; P ¼ 0.018) and 65 -74 years (44.7%; P ¼ 0.049), whereas in the LS area no significant decrease was detected in any age group. The relatively low compliance in the first years of the programme in both areas, and the long enrolment period in the LS area could have reduced the effect on mortality. Our findings suggest that the drop in mortality in the ES area (41%) could be explained by both service screening and better care. The slight decrease in mortality in the LS area (11%) could be mainly due to better care. A reduction of about 30% is attributable to screening in the ES area over the period 1985 -2000. Mammographic screening has been shown to reduce breast cancer mortality rates (Vainio and Bianchini, 2002). Several studies in northern European countries (Hermon and Beral, 1996;Hakama et al, 1997; Van den Akker-van Marle et al, 1999;Blanks et al, 2000;Jonsson et al, 2001;Botha et al, 2003;Otto et al, 2003;Tabar et al, 2003) have reported a decrease in breast cancer mortality where nationwide screening programmes have been implemented. There has, however, been considerable debate concerning the relative contributions of screening and of improved therapy to the observed trends (Carnon et al, 1996;Blanks et al, 2000;Peto et al, 2000).At the beginning of the 1970s in 23 rural municipalities of the province of Florence, Italy (early screening area (ES area) among about 70 000 resident women aged 25 or over, 18% of women of the province, based on 1991 Census), a mammographic screening programme was started; until 1989, women in the 40 -69 year age group were invited, whereas from that year onwards the target population was restricted to age group 50 -69 years. The number of mammograms performed in the ES area was 8000 -9000 per year. The efficacy of the programme on breast cancer mortality in the ES area has been evaluated for the period 1977 -1984 by means of case -control studies (Palli et al, 1986(Palli et al, , 1989, and by using early indicators of efficacy (Paci et al, 1990). After 1990, when the screening for women aged 50 -69 years started in the rest of the province, including the city of Florence (late screening area: LS area), the number of mammograms in the whole province increased to 28 000 -29 000 per year (Barchielli et al, 1999).In this study, we have compared breast cancer mortality rates in the period 1985 -2000 in the ES and LS areas. MATERIALS AND METHODS Sources of data Statistical analysisAdjusted mortality and incidence rates using direct standardisation to the European Standard Population, and age-specific (35 -44, 45 -...

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“…Service studies of mammography screening using a variety of methodologies in the United Kingdom (Quinn and Allen, 1995; UK Trial of Early Detection of Breast Cancer group, 1999; Blanks et al , 2000; Threlfall et al , 2003), Holland (Broeders et al , 2001; Otto et al , 2003), Finland (Anttila et al , 2002), Sweden (Jonsson et al , 2001; Tabár et al , 2001, 2003; Duffy et al , 2003) and Australia (Taylor et al , 2004, 2009; Roder et al , 2008; Morrell et al , 2012; Nickson et al , 2012) have indicated lower mortality associated with screening compared with non-screened populations, although not all results reached statistical significance. Australian studies have shown significant breast cancer mortality reductions associated with screening mammography using a variety of study designs and analytical approaches (Taylor et al , 2004, 2009; Roder et al , 2008; Morrell et al , 2012).…”

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confidence: 99%

Mammography service screening and breast cancer mortality in New Zealand: a National Cohort Study 1999–2011

et al. 2017

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Background:This breast cancer mortality evaluation of service screening mammography in New Zealand, the first since commencement of screening in 1999, applies to the 1999–2011 diagnostic period. Individual-level linked information on mammography screening, breast cancer diagnosis and breast cancer mortality is used to analyse differences in breast cancer mortality according to participation in organised screening mammography, as provided by BreastScreen Aotearoa (BSA).Methods:Women were followed from the time they became eligible for screening, from age 50 years (1999–2004) and 45 years (⩾2004). Breast cancer mortality from cancers diagnosed during the screening period from 1999 to 2011 (n=4384) is examined in relation to individual screening participation or non-participation during preceding person-years of follow-up from the time of screening eligibility. To account for changes from never- to ever-screened status, breast cancer mortality is calculated for each year in relation to prior accumulated time of participation and non-participation in screening. Breast cancer mortality is also examined in regularly screened women (screened ⩾3 times and mean screening interval ⩽30 months), and irregularly screened women compared with never-screened women. Statistical analyses are by negative binomial and Poisson regression with adjustment for age and ethnic group (Māori, Pacific women) in a repeated-measures analysis. Relative risks for breast cancer mortality compared with never-screened women, are adjusted also for screening selection bias, to indicate the extent of breast cancer mortality reduction in a population offered and not offered mammography screening. Prognostic indicators at diagnosis of breast cancer are also compared between different screening participation groups, including by grade of tumour, extent of disease (spread), multiple tumour status and maximum tumour size using χ2 statistics, t-tests and two-sample median tests.Results:For 1999–2011, after adjusting for age and ethnicity, breast cancer mortality in ever-screened women is estimated to be 62% (95% CI: 51–70) lower than in never-screened women. After further adjustment for screening selection bias, the mortality reduction in NZ is estimated to be 29% (95% CI: 20–38) at an average screening coverage of 64% for 2001–2011, and 34% (95% CI: 25–43) for recent screening coverage (2012–13, 71%). For irregularly screened women, the mortality reduction is estimated to be 31% (95% CI: 21–40), and 39% (95% CI: 22–52) in regularly screened women compared with never-screened women, after adjusting for age, ethnicity and screening selection bias (using recent 2012–2013 screening coverage of 71%). Ever-screened women diagnosed with breast cancer have more favourable prognostic indicators than never-screened women, with a higher proportion of localised cancer (63 compared with 46%), a higher proportion with a well-differentiated tumour (30 compared with 18%), lower risk of multiple tumours (RR=0.48) and smaller median tumour size (15 mm compared with 20 mm)—a...

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Diverging breast cancer mortality rates in relation to screening? A comparison of Nijmegen to Arnhem and the Netherlands, 1969-1997

Cited by 21 publications

References 38 publications

Screening Mammography & Breast Cancer Mortality: Meta-Analysis of Quasi-Experimental Studies

Screening Mammography & Breast Cancer Mortality: Meta-Analysis of Quasi-Experimental Studies

Breast cancer mortality trends in two areas of the province of Florence, Italy, where screening programmes started in the 1970s and 1990s

Mammography service screening and breast cancer mortality in New Zealand: a National Cohort Study 1999–2011

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