Divergent time-varying connectivity of thalamic sub-regions characterizes clinical phenotypes and cognitive status in multiple sclerosis

Carotenuto, Antonio; Valsasina, Paola; Cruz, Milagros Hidalgo de la; Cacciaguerra, Laura; Preziosa, Paolo; Marchesi, Olga; Filippi, Massimo; Rocca, Maria A.

doi:10.1038/s41380-021-01401-w

Cited by 4 publications

(9 citation statements)

References 42 publications

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“…Although this might seem surprising, the contribution of the sensorimotor system to cognition aligns with the emerging evidence that motor and cognitive functions are interrelated as shown in MS patients with concomitant involvement of physical and cognitive disability but also in patients with Alzheimer's disease. 34,35 Our hypothesis is that the increased TVC in the sensorimotor system, which occurs after the demyelinating attack in NMOSD (possibly as an attempt of adaptive functional reorganization, as shown in other disorders) 17 might interfere with the cognitive processes intermingled with the motor functions. Conversely, the involvement of the occipital cortex in high-cognitive functions was already described in blind people, 36 suggesting that a similar phenomenon of cross-modal plasticity might occur in neurological disorders characterized by severe visual loss, such as NMOSD.…”

Section: Discussionmentioning

confidence: 99%

“…SFC of the precuneus was assessed by producing a mean map of FC across all sliding windows. 17 , 18 The SD of the FC map across all windows was chosen as a measure of TVC. 17 , 27 …”

Section: Methodsmentioning

confidence: 99%

“…SFC of the precuneus was assessed by producing a mean map of FC across all sliding windows. 17,18 The SD of the FC map across all windows was chosen as a measure of TVC. 17,27 Statistical analysis Between-group comparisons of demographic, neuropsychological and structural MRI variables were performed using two-sample t-test/non-parametric Mann-Whitney U-test, according to normality assumption.…”

Section: Rs Fc Analysismentioning

confidence: 99%

“…17,18 The SD of the FC map across all windows was chosen as a measure of TVC. 17,27 Statistical analysis Between-group comparisons of demographic, neuropsychological and structural MRI variables were performed using two-sample t-test/non-parametric Mann-Whitney U-test, according to normality assumption. Categorical variables, including frequency of mild depressive symptoms between cognitively impaired and preserved patients, were compared by Pearson's chi-squared test.…”

Section: Rs Fc Analysismentioning

confidence: 99%

“…TVC was already investigated in other inflammatory neurological disorders, such as MS, where it detected changes in brain functional reorganization since the earlier phases of the disease, 16 underlined the existence of heterogeneous patterns of connectivity at different disease stages (i.e. relapsing–remitting vs progressive MS) 17 and showed that slower inter-network connectivity 18 and inefficient maintenance of stable intra-network connections 17 contributed to CI.…”

Section: Introductionmentioning

confidence: 99%

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Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study

et al. 2022

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Background: The precuneus is involved in cognition and depression; static functional connectivity (SFC) abnormalities of this region have been observed in neuromyelitis optica spectrum disorders (NMOSD). Time-varying functional connectivity (TVC) underpins dynamic variations of brain connectivity. Objective: The aim of this study was to explore precuneus SFC and TVC in NMOSD patients and their associations with neuropsychological features. Methods: This retrospective study includes 27 NMOSD patients and 30 matched healthy controls undergoing resting state functional magnetic resonance imaging (MRI) and a neuropsychological evaluation of cognitive performance and depressive symptoms. A sliding-window correlation analysis using bilateral precuneus as seed region assessed TVC, which was quantified by the standard deviation of connectivity across windows. Mean connectivity indicated SFC. Results: Compared to controls, patients had reduced SFC between precuneus, temporal lobe, putamen and cerebellum, and reduced TVC between precuneus and prefronto-parietal-temporo-occipital cortices and caudate. Patients also had increased intra-precuneal TVC and increased TVC between the precuneus and the temporal cortex. More severe depressive symptoms correlated with increased TVC between the precuneus and the temporal lobe; worse cognitive performance mainly correlated with higher TVC between the precuneus and the parietal lobe. Conclusion: TVC rather than SFC of the precuneus correlates with NMOSD neuropsychological features; different TVC abnormalities underlie depressive symptoms and cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

“…SFC of the precuneus was assessed by producing a mean map of FC across all sliding windows. 17 , 18 The SD of the FC map across all windows was chosen as a measure of TVC. 17 , 27 …”

Section: Methodsmentioning

confidence: 99%

Section: Rs Fc Analysismentioning

confidence: 99%

Section: Rs Fc Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study

et al. 2022

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Multiplex dynamic networks in the newborn brain disclose latent links with neurobehavioral phenotypes

Al‐Sa'd,

Vanhatalo,

Tokariev

2024

Human Brain Mapping

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The higher brain functions arise from coordinated neural activity between distinct brain regions, but the spatial, temporal, and spectral complexity of these functional connectivity networks (FCNs) has challenged the identification of correlates with neurobehavioral phenotypes. Characterizing behavioral correlates of early life FCNs is important to understand the activity dependent emergence of neurodevelopmental performance and for improving health outcomes. Here, we develop an analysis pipeline for identifying multiplex dynamic FCNs that combine spectral and spatiotemporal characteristics of the newborn cortical activity. This data‐driven approach automatically uncovers latent networks that show robust neurobehavioral correlations and consistent effects by in utero drug exposure. Altogether, the proposed pipeline provides a robust end‐to‐end solution for an objective assessment and quantitation of neurobehaviorally meaningful network constellations in the highly dynamic cortical functions.

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Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

Li,

Long,

Liu

et al. 2024

CNS Neurosci Ther

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PurposeTo investigate dynamic functional connectivity (dFC) within the cerebellar‐whole brain network and dynamic topological properties of the cerebellar network in obstructive sleep apnea (OSA) patients.MethodsSixty male patients and 60 male healthy controls were included. The sliding window method examined the fluctuations in cerebellum‐whole brain dFC and connection strength in OSA. Furthermore, graph theory metrics evaluated the dynamic topological properties of the cerebellar network. Additionally, hidden Markov modeling validated the robustness of the dFC. The correlations between the abovementioned measures and clinical assessments were assessed.ResultsTwo dynamic network states were characterized. State 2 exhibited a heightened frequency, longer fractional occupancy, and greater mean dwell time in OSA. The cerebellar networks and cerebrocerebellar dFC alterations were mainly located in the default mode network, frontoparietal network, somatomotor network, right cerebellar CrusI/II, and other networks. Global properties indicated aberrant cerebellar topology in OSA. Dynamic properties were correlated with clinical indicators primarily on emotion, cognition, and sleep.ConclusionAbnormal dFC in male OSA may indicate an imbalance between the integration and segregation of brain networks, concurrent with global topological alterations. Abnormal default mode network interactions with high‐order and low‐level cognitive networks, disrupting their coordination, may impair the regulation of cognitive, emotional, and sleep functions in OSA.

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Divergent time-varying connectivity of thalamic sub-regions characterizes clinical phenotypes and cognitive status in multiple sclerosis

Cited by 4 publications

References 42 publications

Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study

Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study

Multiplex dynamic networks in the newborn brain disclose latent links with neurobehavioral phenotypes

Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

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